Prevalence of head and neck cancers in Ahmedabad, Gujarat

Patel, Jagruti A.; Shah, Forum; Kothari, Jagdish M.; Patel, Kaustubh

doi:10.1007/s12070-009-0009-5

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…8,9 The whole spectrum of biopsied head and neck lesions include a variety of differential diagnosis ranging from 10 In the present study, a total of 145 cases were analysed.…”

Section: Discussionmentioning

confidence: 99%

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Histopathological patterns of head and neck lesions - a two year retrospective hospital based study

Sharma¹,

Sharma²,

Gandhi³

et al. 2017

Int J Res Med Sci

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Background: Head and neck lesions include a spectrum of pathological lesions ranging from simple benign to highly malignant entities. These lesions contribute significantly to morbidity and mortality of patients. The aim of this study was to determine the histological patterns of head and neck lesions, both non- neoplastic and neoplastic and to analyse the data in relation to age, gender, topography.Methods: A two year retrospective study was conducted in the Post Graduate Department of Pathology, ASCOMS and Hospital and histopathological data pertaining to all head and neck lesions was reviewed. Each case was analysed with respect to age, gender, site and histological type.Results: One hundred and forty-five cases from the head and neck region were analysed during this two-year period. Age range was from 3 months to 85 years with maximum cases in the age group of 21-50 years (51.03%). The Male: Female ratio was 1.37:1. In our study, 53.79% benign, 24.13% inflammatory and 22.06% malignant cases were recorded. Maximum number of benign lesions was in the age group of 21-50 years. Malignancies were noted to be higher in ages 51 years and above. Squamous cell carcinoma was the most common malignancy observed.Conclusions: We conclude that site specific data like this is helpful in evaluating patterns of head and neck lesions and augment the base line data of institute and the region.

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“…8,9 The whole spectrum of biopsied head and neck lesions include a variety of differential diagnosis ranging from 10 In the present study, a total of 145 cases were analysed.…”

Section: Discussionmentioning

confidence: 99%

“…These findings are indicative of the fact that head and neck cancers are amongst the commonest malignancies in India with Squamous cell carcinoma being the predominant histological type. 3,9,13,15 This could be attributed to the major preventable risk factors which are tobacco use, betel quid chewing and alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

Histopathological patterns of head and neck lesions - a two year retrospective hospital based study

Sharma¹,

Sharma²,

Gandhi³

et al. 2017

Int J Res Med Sci

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“…Inhibition of PGK1 promotes cell apoptosis in glioblastoma cells ( 22 ) and TNBC ( 23 ). Downregulation of PGK1 decreases ATP production and induces apoptosis ( 24 ). Depletion of ATP level, used in combination with chemotherapy has a variety of effects on cancer cells including inducing apoptosis in multidrug resistant cells ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

Silencing of PGK1 Promotes Sensitivity to Paclitaxel Treatment by Upregulating XAF1-Mediated Apoptosis in Triple-Negative Breast Cancer

Sun

et al. 2021

Front. Oncol.

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Objective: Triple negative breast cancer (TNBC) is known to have aggressive clinical course and a high risk of recurrence. Given the lack of effective targeted therapy options, paclitaxel-based chemotherapy is still the primary option for TNBC patients. However, patients who fail to achieve a complete response during neoadjuvant chemotherapy may be mainly due to sensitivity and resistance to chemotherapy. Thus, we concentrated the present research on the role of PGK1 in the sensitivity to paclitaxel treatment and the possible underlying mechanisms in TNBC.Methods: After exposure to paclitaxel, a cell viability analysis was made to investigate the influence of PGK1 silencing on cell death. The effect of PGK1 on apoptosis induced by paclitaxel treatment was examined in vitro by flow cytometry cell apoptosis assays. Western blotting was performed to examine the impact of PGK1 on paclitaxel-induced apoptosis. The correlation of PGK1 with apoptosis-associated protein X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) was analyzed in 39 specimens by immunohistochemistry analysis.Results: We observed that silencing PGK1 sensitized triple-negative breast cancer (TNBC) cell lines to paclitaxel treatment as a result of increased drug-induced apoptosis. Furthermore, mechanistic investigations suggested that XAF1 was increased in PGK1-knockdown cells along with the expression of the apoptotic proteins including cleaved caspase-3 and Bax. Immunohistochemistry analysis showed that PGK1 was negatively related to XAF1. Moreover, we found that downregulation of XAF1 reduced paclitaxel-induced apoptosis in PGK1-silenced triple-negative cell lines.Conclusion: Our results identified PGK1 as a potential biomarker for the treatment of TNBC, and inhibition of PGK1 expression might represent a novel strategy to sensitize TNBC to paclitaxel treatment.

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Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India

et al. 2013

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Polymorphic variability in the enzymes involved in biotransformation of tobacco-related pro-carcinogens plays an important role in modulating oral cancer susceptibility. CYP1A1*2A, CYP1A1*2C, GSTM1 and GSTT1 polymorphisms were determined in 122 oral carcinoma cases and 127 controls from Gujarat, West India using PCR-based methods. The results revealed that the polymorphic variants of CYP1A1 gene did not show association towards oral cancer risk. The GSTM1 and GSTT1 null genotypes were found to be over-represented in patients than controls, suggesting a moderate increase in risk of oral cancer. The oral cancer risk was significantly increased in the patients having either alone or concurrent deletion of GSTM1 and GSTT1. The results also suggested significant association between tobacco habits, especially chewing, variant genotypes of CYP1A1, GSTM1 and GSTT1 and oral cancer risk. Our data have provided evidence that GST polymorphism modified the susceptibility to oral cancer and individuals with variant genotypes of the three genes with tobacco habits are at significant risk of developing oral cancer.

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Prevalence of head and neck cancers in Ahmedabad, Gujarat

Cited by 4 publications

References 19 publications

Histopathological patterns of head and neck lesions - a two year retrospective hospital based study

Histopathological patterns of head and neck lesions - a two year retrospective hospital based study

Silencing of PGK1 Promotes Sensitivity to Paclitaxel Treatment by Upregulating XAF1-Mediated Apoptosis in Triple-Negative Breast Cancer

Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India

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