Prevalence of head and neck cancers in ahmedabad, gujarat

Patel, Jagruti A.; Shah, Forum; Kothari, Jagdish M.; Patel, Kaustubh

doi:10.1007/s12070-008-0104-z

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Lesions arising from the head and neck region are challenging and multifarious, each lesionis unique in terms of its epidemiology, history, anatomy and pathological features 3,4 .…”

Section: Discussionmentioning

confidence: 99%

Histomorphological Spectrum of Head and Neck Lesions: A Three Year Retrospective Analysis

Singhal

Nanda

Lamba

et al. 2018

RAPL

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Background: Lesions of head and neck are common in patients of all age groups. Head and neck cancers including thyroid lesions are the third commonest malignancy seen in both sexes across the globe. Aim: To study the histo-pathological spectrum of head and neck lesions in a tertiary care hospital of north India. Material and Methods: Three year retrospective study was conducted in Department of Pathology of tertiary care hospital. The head and neck cases including thyroid were retrieved from the data base of the department and analyzed with respect to age, gender, topography and histo-pathological diagnosis. Results: Out of 4092 biopsies received during a three year period, 158 biopsies were from the head and neck area. The age range was 4-86 years. Maximum number of cases were seen in the age group of 41-60 years. The male female ratio was 2.5:1.89 cases were benign, 6 were borderline, 4 inconclusive and 59 were malignant. Commonest malignancy was squamous cell carcinoma of oral cavity and commonest benign lesion was epidermoid cyst. Conclusions: Information relating to site specific data forms a scientific basis for developing strategies to prevent and diagnose various lesions especially cancers.

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“…Lesions arising from the head and neck region are challenging and multifarious, each lesionis unique in terms of its epidemiology, history, anatomy and pathological features 3,4 .…”

Section: Discussionmentioning

confidence: 99%

Histomorphological Spectrum of Head and Neck Lesions: A Three Year Retrospective Analysis

Singhal

Nanda

Lamba

et al. 2018

RAPL

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“…The present study had 62.3% of cases in younger age (<45 years) group. This region is exhibiting a serious trend in increase in the incidence of oral cancer cases (Patel et al , ).…”

Section: Discussionmentioning

confidence: 99%

Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India

et al. 2013

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Polymorphic variability in the enzymes involved in biotransformation of tobacco-related pro-carcinogens plays an important role in modulating oral cancer susceptibility. CYP1A1*2A, CYP1A1*2C, GSTM1 and GSTT1 polymorphisms were determined in 122 oral carcinoma cases and 127 controls from Gujarat, West India using PCR-based methods. The results revealed that the polymorphic variants of CYP1A1 gene did not show association towards oral cancer risk. The GSTM1 and GSTT1 null genotypes were found to be over-represented in patients than controls, suggesting a moderate increase in risk of oral cancer. The oral cancer risk was significantly increased in the patients having either alone or concurrent deletion of GSTM1 and GSTT1. The results also suggested significant association between tobacco habits, especially chewing, variant genotypes of CYP1A1, GSTM1 and GSTT1 and oral cancer risk. Our data have provided evidence that GST polymorphism modified the susceptibility to oral cancer and individuals with variant genotypes of the three genes with tobacco habits are at significant risk of developing oral cancer.

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Prevalence of head and neck cancers in ahmedabad, gujarat

Cited by 2 publications

References 18 publications

Histomorphological Spectrum of Head and Neck Lesions: A Three Year Retrospective Analysis

Histomorphological Spectrum of Head and Neck Lesions: A Three Year Retrospective Analysis

Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India

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