Purpose: The aim of this study was to investigate the effects of occipital nerve block (ONB) in pediatric patients with headache in the occipital region.Methods: Among 302 patients who visited our headache clinic during a 2-year period, we retrospectively reviewed the charts of 26 patients who complained of primary headache in the occipital region, and divided them into two groups according to the main treatment: ONB or oral drug treatment (ODT).Results: The mean age of the 26 patients was 11.7±3.2 years. No statistically significant differences were found between the ONB and ODT groups in age, sex, sites of pain, duration of having experienced symptoms, and the duration, frequency, and severity of episodes (P>0.05). There was no statistically significant difference in remission between the ONB and ODT groups. However, in the ONB group, the time taken to achieve remission was significantly shorter than in the ODT group (P<0.05). Additionally, in the ONB group, the duration of medication and the period of outpatient treatment were significantly shorter than in the ODT group (P<0.05).Conclusion: In this study, ONB reduced the time taken to achieve remission and shortened the period of treatment. Thus, ONB should be considered in pediatric patients with headache in the occipital region.