Objectives: To investigate health anxiety and depressive symptoms in patients with fibromyalgia syndrome (FMS). Methods: Patients with FMS and healthy control subjects were recruited. All participants completed the Health Anxiety Inventory Short Form (HAI-SF) and Beck Depression Inventory (BDI). Pain was assessed in patients with FMS using the Fibromyalgia Impact Questionnaire (FIQ) and Visual Analogue Scale (VAS). Results: This study involved 95 patients with FMS (15 male) and 95 healthy controls (17 male). Mean AE SD HAI-SF and BDI scores were significantly higher in patients with FMS ¼ than in controls¼. HAI-SF scores were 23.50 AE 10.78 and 9.38 AE 4.24 respectively; BDI scores were 18.64 AE 10.11 and 6.21 AE 4.05 respectively. There were highly significant correlations between FIQ and HAI-SF, FIQ and BDI, and HAI-SF and BDI. Conclusions: Patients with FMS had significantly higher HAI-SF and BDI scores than healthy controls. Psychiatric support is essential for patients with FMS. Treatment should include biological, psychological and social approaches.