Prevalence of Helicobacter pylori from the oral cavity of Mexican asymptomatic children under 5 years of age through PCR

Castro-Muñoz, Leonardo Josué; González-Díaz, César Antonio; Muñoz-Escobar, Aide; Tovar-Ayona, Brisna Joana; Aguilar-Anguiano, Luz María; Vargas-Olmos, Rebeca; Sánchez-Monroy, Virginia

doi:10.1016/j.archoralbio.2016.09.007

Cited by 27 publications

(23 citation statements)

References 28 publications

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“…Therefore, it remains unclear whether H. pylori can survive in the oral environment. On the other hand, an original article this year studied the prevalence of oral H. pylori in asymptomatic Mexican children under five and reported it to be 13% by PCR, the results being confirmed by sequencing and showing more than 97% identity with H. pylori …”

Section: Reservoirs Of H Pylori and Its Transmissionmentioning

confidence: 99%

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Epidemiology of Helicobacter pylori infection

2017

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The study of Helicobacter pylori genetic variability brought us interesting data on the history of mankind. Based on multilocus sequence typing and more recently on whole-genome sequencing, paleomicrobiology still attracts the attention of global researchers in relation to its ancestor roots and coexistence with humans. Three studies determining the prevalence of virulence factors illustrates the controversial results obtained since 30 years by studies trying to associate prevalence of different virulence markers and clinical outcomes of H. pylori infection. Three articles analyzed the prevalence and risk of multiple (genetically distinct isolates) and mixed (susceptible and resistant isolates) infections. A number of studies confirm that H. pylori prevalence is falling worldwide especially in the developed world and in children but that the level of infection is higher in certain ethnic minorities and in Migrants. There is little new in identifying the mode of H. pylori transmission though intrafamilial spread appears to be important. There have, however, been some interesting papers on the presence of the organism in food, water, and the oral cavity.

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Section: Reservoirs Of H Pylori and Its Transmissionmentioning

confidence: 99%

“…However, the reviewers consider that H. pylori can be identified unequivocally identity with H. pylori. 15 Transmission by infected water has long been a concern and has been extensively reviewed this year. 16 An American article 17 ing showed them to be highly resistant to a wide range of antibiotics.…”

Section: Reservoirs Of H Pylori and Its Transmissionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection

2017

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“…The prevalence of H. pylori , assessed by a HpSA, among 240 asymptomatic children living in a rural setting in sub‐Saharan Africa, was 14.2% . The prevalence of H. pylori assessed by oral swabs using PCR in 162 asymptomatic Mexican children was 13% …”

Section: Epidemiologymentioning

confidence: 99%

“…11 The prevalence of H. pylori assessed by oral swabs using PCR in 162 asymptomatic Mexican children was 13%. 12 Finally, the intrafamilial transmission of H. pylori was explored in Iranian children who required an upper gastrointestinal endoscopy as well as in their parents. According to the genotyping results of H. pylori strains isolated in 30 families, 10 (33.3%) children exhibited H. pylori with related genotypes to their mothers, while only two children (6.7%) had H. pylori genotypes similar to their fathers.…”

Section: Respectivelymentioning

confidence: 99%

Helicobacter pylori infection in children

2017

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Helicobacter pylori infection in children differs from that in adults, from the point of view of epidemiology, host response, clinical features, related diseases, and diagnosis, as well as treatment strategies. The prevalence of H. pylori infection, in both children and adults, is decreasing in the Western World as well as in some developing countries, which contrasts with the increase in childhood asthma and allergic diseases. Recurrent abdominal pain is not specific during H. pylori infection in children. The role of H. pylori infection and failure to thrive, children's growth, type I diabetes mellitus (T1DM) and celiac disease remains controversial. The main initial diagnosis is based on upper digestive endoscopy with biopsy-based methods. Nodular gastritis may be a pathognomonic endoscopic finding of childhood H. pylori infection. The infection eradication control is based on validated noninvasive tests. The main cause of treatment failure of H. pylori infection is its clarithromycin resistance. We recommend standard antibiotic susceptibility testing of H. pylori in pediatric patients prior to the initiation of eradication therapy. H. pylori treatment in children should be based on an evaluation of the rate of eradication in the local population, a systematic use of a treatment adapted to the susceptibility profile and a treatment compliance greater than 90%. The last meta-analysis in children did not show an advantage for sequential therapy when compared to a 14-day triple therapy. Finally, the high rate of antibiotic resistance responsible for therapy failure in recent years justifies the necessity of a novel vaccine to prevent H. pylori infection in children.

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“…Various antiplaque and antimicrobial agents are known for inhibiting the growth or killing the target bacteria present in the oral microenvironment. These solutions may consist of chlorhexidine [41], essential oil [42], cetylpyridinium chloride [43], povidone-iodine [44], etc. In our study, we investigated the effect of these oral rinses on H. pylori growth and its carcinogenic abilities.…”

Section: Discussionmentioning

confidence: 99%

Oral rinses in growth inhibition and treatment of Helicobacter pylori infection

et al. 2020

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Background: Helicobacter pylori (H. pylori) is well-known for its role in chronic gastritis and gastric cancer. Eradication of these carcinogenic bacteria from the gut is one of the challenges for clinicians. The complexity of treatment mainly owes to antibiotic resistance and relapse due to an additional reservoir in the oral cavity. Our study emphases the isolation of H. pylori from distinct habitats of the gut microenvironment (gastric biopsy and gastric juice) and its subsequent characterization. We have also evaluated the effect of various oral rinses on isolated H. pylori from different anatomical locations of included subjects. Results: The possible strains isolated from two different habitats of the same subject shows a striking difference in their growth pattern. Promisingly, some of the included oral rinses are efficient in growth inhibition as per recommended 30 s treatment. The subsequent evaluation shows that oral rinse B (among A-E) is most effective and down-regulates the expression of one of the potent H. pylori gene, CagA, in the infected gastric adenocarcinoma (AGS) cells. Conclusion:Our study, for the first time, revealed that H. pylori, isolated from the different habitat of the same subject, show a different growth pattern. The expression of H. pylori pathogenic gene (CagA) was down-regulated by the use of oral rinses. Hence, oral rinses will reduce the H. pylori in the oral cavity and help to control its migration from oral to the gastric compartment and may be used as an adjuvant treatment option for its reinfection.

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Prevalence of Helicobacter pylori from the oral cavity of Mexican asymptomatic children under 5 years of age through PCR

Cited by 27 publications

References 28 publications

Epidemiology of Helicobacter pylori infection

Epidemiology of Helicobacter pylori infection

Helicobacter pylori infection in children

Oral rinses in growth inhibition and treatment of Helicobacter pylori infection

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