Prevalence of Helicobacter pylori in symptomatic patients and detection of clarithromycin resistance using melting curve analysis

Kaya, Aşkı Ellibeş; Öztürk, Cihadiye Elif; Akcan, Yusuf; Behçet, Mustafa; Karakoç, Ayşe Esra; Yücel, Mihriban; Mısırlıoğlu, Müge; Tunçer, Serdar

doi:10.1016/j.curtheres.2007.06.001

Cited by 12 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sensitivity of culture method to detect H. pylori, in adult population, ranges from 62.7% to 96.3% in the studies performed [8,10,12].…”

Section: 68%mentioning

confidence: 99%

See 1 more Smart Citation

A Study of the Correlation between Bacterial Culture and Histological Examination in Children with Helicobacter pylori Gastritis

Galoș¹,

Năstase²,

Boboc³

et al. 2019

Histology

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is one of the most common chronic bacterial infections in the world, and it is currently estimated that approximately half of the world's population is infected with the bacterium. The correct diagnosis and effective treatment of H. pylori gastric infection are essential in controlling this condition. The available diagnostic methods have advantages and limitations related to factors such as age of patients, technical difficulty level, costs and extensive accessibility in hospitals. The eradication therapy of H. pylori infection is still a challenge for gastroenterologists. One of the main causes of failure in H. pylori eradication is antibiotic resistance. Biopsy cultures are the most widely used methods among the antimicrobial susceptibility tests. In case of a negative culture, H. pylori can be clearly recognised in histological sections. The sensitivity and specificity of histology for the diagnosis depend on clinical settings, density of colonisation and the experience of the histopathologist. A prospective study was performed in order to analyse patients with H. pylori gastric infection with positive histology and positive culture versus positive histology and negative culture.

show abstract

“…The sensitivity of culture method to detect H. pylori, in adult population, ranges from 62.7% to 96.3% in the studies performed [8,10,12].…”

Section: 68%mentioning

confidence: 99%

“…Our results are less significant if compared to other published data in which higher percentages of positive cultures were obtained, except one. Kaya et al reported the sensitivity for H. pylori culture as 22.5%, and the specificity as 97.1%[10].…”

mentioning

confidence: 99%

A Study of the Correlation between Bacterial Culture and Histological Examination in Children with Helicobacter pylori Gastritis

Galoș¹,

Năstase²,

Boboc³

et al. 2019

Histology

View full text Add to dashboard Cite

show abstract

“…There were no other data to compare the results [31]. There were no other data to compare the results [31].…”

Section: Prevalence Of Primary Clarithromycin Resistancementioning

confidence: 99%

“…For the north region of Turkey, there was only one study, and the primary clarithromycin resistance rate was reported as 30%. There were no other data to compare the results [31]. The highest primary clarithromycin resistance rates were obtained from the central (50%; 2007) [25] and west regions (48.2%; 2003-2004) [15].…”

Section: Prevalence Of Primary Clarithromycin Resistancementioning

confidence: 99%

Prevalence of Primary Antimicrobial Resistance of H. pylori in Turkey: A Systematic Review

Kocazeybek

Tokman

2015

Helicobacter

View full text Add to dashboard Cite

Primary antibiotic resistance against H. pylori in Turkey shows differences between geographical regions and population densities. There is an increase in primary resistance rates to clarithromycin and metronidazole in different years. The data are not sufficient for tetracycline, amoxicillin, and levofloxacin. High clarithromycin resistance rates were mostly detected in overpopulated cities like Ankara (north), Izmir (west), Istanbul (west), and Bursa (west).

show abstract

“…In fact, we elected to include this step in the study for safety reasons to detect any serious underlying condition that can be missed in some cases (30), as well as to further validate the usefulness and accuracy of the alarm features mentioned in the guidelines. (iii) In Turkey, clarithromycin resistance has a prevalence of around 24-48% (31)(32)(33). The use of a triple treatment that included clarithromycin for the eradication of H. pylori may have resulted in both a lower eradication rate and a lower proportion of patients who achieved sufficient overall symptom relief.…”

Section: Limitations Of This Trialmentioning

confidence: 99%

Effect of pantoprazole and Helicobacter pylori therapy on uninvestigated dyspeptic patients

Baysal

Şentürk²,

Masri³

et al. 2015

Turk J Gastroenterol

View full text Add to dashboard Cite

Background/Aims: This study aimed to test the efficacy of empirical proton pump inhibitor use and Helicobacter pylori therapy for uninvestigated dyspepsia in a population with a high prevalence of H. pylori. Material and Methods: The study had a two-stage design. In the first stage, the efficacy of 4-week pantoprazole treatment was compared with placebo in patients with uninvestigated dyspepsia. In the second stage, the efficacies of 2-week treatment with pantoprazole in H. pylori-negative patients and H. pylori eradication therapy (pantoprazole + amoxicillin + clarithromycin) in H. pylori-positive patients were compared. The primary endpoint was sufficient overall symptom relief (Global Overall Symptom score ≤2; no or minimal symptoms) at the end of treatment. Results: In the first stage, sufficient overall symptom relief was achieved by 25.2% of patients in the pantoprazole group and 15.5% of patients in the placebo group, a difference that was not statistically significant (p=0.06). In the second stage, the rate of sufficient overall symptom relief was higher in the H. pylori therapy group than in the pantoprazole group (37.1% vs. 23.4%; p=0.02). After untreated follow-up, sufficient overall symptom relief remained significantly higher in the H. pylori therapy group than in the pantoprazole group (39.7% vs. 18%; p<0.001). Almost all patients receiving pantoprazole experienced symptom relapse after treatment. Conclusions: This study validated the use of a test-and-treat strategy against H. pylori in uninvestigated dyspepsia, which may be an advisable treatment approach for uninvestigated dyspeptic patients in countries with a high prevalence of H. pylori.

show abstract

Prevalence of Helicobacter pylori in symptomatic patients and detection of clarithromycin resistance using melting curve analysis

Cited by 12 publications

References 20 publications

A Study of the Correlation between Bacterial Culture and Histological Examination in Children with Helicobacter pylori Gastritis

A Study of the Correlation between Bacterial Culture and Histological Examination in Children with Helicobacter pylori Gastritis

Prevalence of Primary Antimicrobial Resistance of H. pylori in Turkey: A Systematic Review

Effect of pantoprazole and Helicobacter pylori therapy on uninvestigated dyspeptic patients

Contact Info

Product

Resources

About