Prevalence of Helicobacter pylori infection, its correlation with gastroduodenal diseases and the incidence of gastric cancer in Nepal

Shrestha, Umid Kumar; Ghosh, Arnab; Alurkar, Vijay Madhav; Kohli, Suresh Chandra; Sapkota, Subash

doi:10.3126/jaim.v2i2.8777

Cited by 10 publications

(13 citation statements)

References 35 publications

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“…Demographically, Gastric cancer was found commonly in 61-70 years, and in Gurung community (Janajati-Hill in our category) in a study by Ghosh et al 13,23 In our series, though Janajatis comprise 37% of the population, they accounted for 42% of cases of gastric carcinomas and around 65% of the patients were concentrated on 20 districts (25% of the geography). Since these patients belong to the hilly region of the country, it limits their accessibility to health care facilities and devoid them of the benefit of early diagnosis and cure.…”

Section: Discussionsupporting

confidence: 46%

“…3 In a study done in Kaski district of Nepal, it was found to be 3.3 per 100000. 13 In Nepal the age standardized death rate from gastric cancer for 2010 is 8.38 and Nepal ranks 71 st in the world rank in gastric cancer. 14 Nepal is a developing country with limited recourses and the difficult terrain limits accessibility of health care facility by the general population.…”

Section: Introductionmentioning

confidence: 99%

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Post Operative Diagnosis of Early Gastric Cancer in a Low Risk Population and the Possibility of Risk Stratified Screening

Ghimire

Singh²,

Timalsina

2015

Kathmandu Univ. Med. J.

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Background Gastric cancer is the second commonest cause of cancer related mortality worldwide. Though its incidence is more in Eastern Asia, it is increasing in the South Asian subcontinent. The diagnosis of early gastric cancer (EGC) confined to the mucosa or submucosa, is an important concern due to a better outcome at this stage where five year survival rates could increase by 90 percent. Though mass screening is done in few countries, it has not been applied in developing countries like Nepal. Preoperative diagnosis of EGC is rare in Nepal. The aim of this study is to analyze the clinico-pathological features of postoperative cases of gastric cancer managed in a tertiary care university hospital of Nepal.Methods All patients with histological diagnosis of gastric cancer admitted in the Department of Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal during the three year period (September 2010 to August 2013) were analyzed retrospectively.Results Ninety two patients with endoscopic diagnosis of gastric cancers were admitted during the past three years. The mean age was 60 years ranging from 28 years to 85 years with the male to female ratio of 2.8:1. Five patients were younger than 40 years and all were in advanced stage. Thirty five percent of the patients belonged to Janajatis (Hill) community though they comprise only 23% of the population and about 65% of them belonged to an area involving 25% of the country.Seventy six cases were operated. Out of 92 patients, 4 patients were diagnosed as early gastric cancer postoperatively. All patients with early gastric cancer were above 50 years with CT Scan abdomen revealing focal thickening without lymphadenopathy.Conclusion Over the years, the incidence of gastric cancer is increasing in Nepal. Though 92% are advance gastric cancers, few have been diagnosed and treated early. A screening program in a country like Nepal with diverse ethnicity and difficult terrain might be helpful if it targets high risk people in high risk areas.Kathmandu University Medical Journal Vol.12(1) 2014: 32-37

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Section: Discussionsupporting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Post Operative Diagnosis of Early Gastric Cancer in a Low Risk Population and the Possibility of Risk Stratified Screening

Ghimire

Singh²,

Timalsina

2015

Kathmandu Univ. Med. J.

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“…In the current study, the prevalence of gastric cancer among patients undergoing UGI endoscopies was 2.4%. In a previous Nepalese study from this region in 2013 comprising of 2820 endoscopies by Shrestha et al 6 , gastric carcinoma prevalence was reported to be 1.8%. The prevalence or detection of gastric cancer may be rising every year in this region.…”

Section: Discussionmentioning

confidence: 89%

Prevalence of Gastric Cancers among Patients Undergoing Upper Gastrointestinal Endoscopies in a Tertiary Care Hospital in Nepal: A Descriptive Cross-sectional Study

2020

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Introduction: Gastric cancer is a common malignancy of the upper gastrointestinal tract. Gastric cancer is a common cause of death worldwide. This research aimed to study the prevalence of gastric cancer among patients undergoing upper gastrointestinal endoscopies. Methods: A descriptive, cross-sectional study was conducted in the Department of Medicine at Manipal Teaching Hospital, Nepal, from January 2018 to June 2020. A total of 2640 subjects underwent upper gastrointestinal endoscopies over the study period. Ethical approval was taken from the institutional review committee of Manipal College of Medical Sciences (MEMG/ IRC/ 383/GA). Data were analyzed by SPSS version 20. Results: The prevalence of gastric cancer among patients undergoing UGI endoscopies was 2.4%. The mean age of subjects was 58 Â± 12.35 years (range of 31 to 96 years) with male predominance (M:F=1.9:1). Antrum was the most common site for gastric carcinoma. The most common morphology was ulcerative growth (61.6%). Adenocarcinoma (98.4%) was the most common histology, and the majority was of intestinal subtype (56.3%). Conclusions: Gastric cancer is not an uncommon finding in patients undergoing UGI endoscopies. Gastric cancers were commonly seen above 50 years of age and predominant in males. Patients with gastric carcinoma usually present late with advanced disease stages and unfavorable histopathology.

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“…Females are more frequently affected by cancer than males [ 28 ]. However, age-standardized annual gastric cancer has a prevalence of 3.3 in 100,000 [ 29 ] and a male-female ratio of 2.8:1 [ 23 ]. Women of advanced age have high prevalence of breast lumps and breast cancer [ 28 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

Burgeoning burden of non-communicable diseases in Nepal: a scoping review

et al. 2015

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In the last decades, prevalence of non-communicable diseases (NCDs) has escalated in Nepal. This study reviews existing evidence on the burden of non-communicable diseases in Nepal using the framework developed by Arksey and O’Malley for scoping reviews. A total of 110 articles were identified from database searches, and four from additional searches. The titles and abstracts were reviewed using predetermined screening criteria. We limited our search to existing literature in English language and included all studies regardless of year of study. Both observational and interventional studies were included. Studies conducted outside Nepal and studies not reporting prevalence of NCDs were excluded. Additionally, we searched reference lists of included publications. All previous reports of Step Wise Surveillance to NCDs (STEPS Surveys) were included in the review. Finally, a total of 60 articles were included in this review. Limited studies on population-based prevalence of mental illness, chronic respiratory diseases, cardiovascular diseases, and road traffic accidents were found. There were limitations in the studies related to generalizability due to small sample sizes, non-random sampling and lack of studies from certain region of country. Nevertheless, high prevalence of hypertension and diabetes was found. Similarly, hospital-based studies reported high burden of cardiovascular diseases among outpatient contacts. Population-based cancer registries do not exist in Nepal. However, existing studies report 8,000-10,000 cancer deaths annually in Nepal. The most common cancer site in males was the lung, followed by the oral cavity and gastric, while the first three in females were cervix uteri, breast and lung. Prevalence of psychiatric morbidity was also high. Despite alarming burden of NCDs, the country’s response is weak. Nepal needs to build non-communicable disease programmes with focus on disease prevention and management as well as awareness activities in urban and rural settings at community level.Electronic supplementary materialThe online version of this article (doi:10.1186/s12992-015-0119-7) contains supplementary material, which is available to authorized users.

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Prevalence of Helicobacter pylori infection, its correlation with gastroduodenal diseases and the incidence of gastric cancer in Nepal

Cited by 10 publications

References 35 publications

Post Operative Diagnosis of Early Gastric Cancer in a Low Risk Population and the Possibility of Risk Stratified Screening

Post Operative Diagnosis of Early Gastric Cancer in a Low Risk Population and the Possibility of Risk Stratified Screening

Prevalence of Gastric Cancers among Patients Undergoing Upper Gastrointestinal Endoscopies in a Tertiary Care Hospital in Nepal: A Descriptive Cross-sectional Study

Burgeoning burden of non-communicable diseases in Nepal: a scoping review

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