Prevalence of Helicobacter pylori infection in Polish shepherds and their families

Papież, D.; Konturek, Peter C.; Bielański, Władysław; Płonka, Małgorzata; Dobrzańska, M.; Kamińska, Agnieszka; Szczyrk, Urszula; Bochenek, Αnna; Wierzchos, E.

doi:10.1016/s1590-8658(02)00004-x

Cited by 29 publications

(29 citation statements)

References 22 publications

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“…Several other studies had highlighted the presence of the microorganism or their DNA in water [7,[14][15][16]. The findings of this study did not also agree with the study by Papiez et al that water-borne transmission of H. pylori could be an important source of infection in developing countries [8]. A study in Guatemala reported that H. pylori was unlikely to be transmitted by water [17] but epidemiological studies in many countries such as China [18], Lima Peru [19], and Colombia [20] had shown that infection was related to H. pylori contaminated water sources.…”

Section: Discussioncontrasting

confidence: 99%

“…Involvement in milking of cows had significant association with transmission of the infection (Table 4). This agreed with the report of Papiez et al who showed a higher prevalence of antibodies against H. pylori among some professions (Abattoir workers, Shepherds and Veterinarians) probably due to direct contact with H. pylori infected animals [8]. Papiez reported that milking appears to be a possible in milk in its infectious bacillary for several months in a nonculturable but viable form [7].…”

Section: Discussionsupporting

confidence: 91%

“…Several studies have shown a possibility of transmission pathway through domestic cats, dogs and sheep [8]. However, this study did not find any association between keeping of domestic animals and H. pylori infection ( Table 4).…”

Section: Discussioncontrasting

confidence: 77%

“…It has been found that H. pylori can live in milk and water in its infectious bacillary form and inriver water for several months in a non-culturable but viable form [7]. Previous serological studies have related a high prevalence of antibodies against H. pylori among someprofessions (Abattoir workers, shepherds and veterinary workers) who are in direct contact with H. pylori infected animals [8]. H. pylori have also been isolated from the intestinal tract of dogs, cats and sheep [9].…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors Associated with Helicobacter Pylori Infections in Makurdi Northcentral Nigeria

Ey¹,

Ebele²,

Emmanuel³

2017

J Infect Dis Ther

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Risk Factors Associated with Helicobacter Pylori Infections in Makurdi Northcentral Nigeria

Ey¹,

Ebele²,

Emmanuel³

2017

J Infect Dis Ther

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“…Studies on Sardinian shepherds with close contact with sheep 15 and school children in rural areas of Sardinia contacting both sheep and sheepdogs revealed that contact with these domestic animals might be a powerful and independent risk factor for H. pylori infection in this Sardinian subpopulation 16 . Our previous study on shepherds from the Polish Tatra Mountains using modified [ 13 C]‐urea breath testing (UBT) 17 and serology revealed a very high active H. pylori infection rate and a high incidence of cytotoxic CagA seropositivity, as well as increased proinflammatory serum cytokine levels when compared with control subjects without sheep contact 18 . Helicobacter pylori infection is not only the major pathogen of the gastrointestinal tract but may also be responsible for growth retardation and reduced appetite, possibly due to inhibition of the expression and release of ghrelin, identified in the oxyntic gland area of the stomach, as an endogenous ligand of growth hormone secretagogue receptor.…”

Section: Introductionmentioning

confidence: 96%

Relationship between ghrelin and Helicobacter pylori infection in Polish adult shepherds and their children

Płonka

Konturek

Bielański

et al. 2006

Ali Pharm Thera Symp Ser

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Summary Background Ghrelin stimulates food intake and body weight gain. The stomach is the major source of circulating ghrelin, but controversy exists over the relationship between ghrelin release and Helicobacter pylori infection. Aim To assess the relationship between H. pylori infection and ghrelin, leptin and gastrin release in adult shepherds and their children, and to measure the effect of H. pylori eradication on gastric ghrelin content. Methods H. pylori prevalence was compared in 42 shepherds with full contact with sheep, 148 farmers without sheep contact and in 61 age‐matched urban adult controls as well as in 58 shepherd children with sheep contact, 88 mountain children without contact and 141 urban children controls. Serum levels of ghrelin, leptin and gastrin in adult shepherds and their children with and without H. pylori infection were measured. Results The major source of circulating ghrelin was gastric corpus mucosa, as ghrelin content was severalfold higher than that in antral mucosa and was significantly higher in the H. pylori‐eradicated than that in H. pylori‐infected mucosa. Serum levels of ghrelin were greatly increased, while gastrin levels were significantly decreased in H. pylori‐negative as compared with H. pylori‐positive subjects. In mountain children, serum levels of ghrelin and leptin were about twofold higher in H. pylori‐negative than in H. pylori‐positive children, whereas gastrin levels were significantly reduced in H. pylori‐negative children. Conclusions The high incidence of H. pylori infection in shepherds and their children seems to contribute to the decreased serum levels of ghrelin and increased levels of gastrin in H. pylori‐infected mountain children and to their decreased appetite and dyspeptic symptoms.

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Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

Kotilea

Bontems

Touati

2019

Advances in Experimental Medicine and Biology

113

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Helicobacter pylori is a human-specific pathogen which leads to gastric pathologies including gastric cancer. It is a highly unique bacterium considered as a carcinogenic agent. H. pylori remains a major human health problem, responsible for ~90% of the gastric cancer cases. Approximately four billion individuals have been detected for H. pylori infection worldwide in 2015. At the turn of the 21 st century, the prevalence of H. pylori has been declining in highly industrialized countries of the Western world, whereas prevalence has plateaued at a high level in developing and newly industrialized countries. However, the infection status remains high in immigrants coming from countries with high prevalence of H. pylori infection. H. pylori can be diagnosed by invasive and non-invasive methods. Urea breath test and stool antigens detection are among the most commonly used non-invasive ones. Although the way H. pylori is transmitted remains still unclear, the level of contamination is strongly dependent on the familial and environmental context, with a drastic impact of living conditions with poor hygiene and sanitation. However, familial socioeconomic status is the main risk factor for H. pylori infection among children. In addition, food and water source have a high impact on the prevalence of H. pylori infection worldwide. This chapter highlights the latest knowledge in the epidemiology of H. pylori infection, its diagnosis and critical risk factors responsible for its high prevalence in some populations and geographic areas.

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Prevalence of Helicobacter pylori infection in Polish shepherds and their families

Cited by 29 publications

References 22 publications

Risk Factors Associated with Helicobacter Pylori Infections in Makurdi Northcentral Nigeria

Risk Factors Associated with Helicobacter Pylori Infections in Makurdi Northcentral Nigeria

Relationship between ghrelin and Helicobacter pylori infection in Polish adult shepherds and their children

Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

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