Prevalence of Hepatitis B and Hepatitis C Virus Co-infection in India: A Systematic Review and Meta-analysis

Desikan, Prabha; Khan, Ziya Ahmad

doi:10.4103/ijmm.ijmm_17_257

Cited by 24 publications

(23 citation statements)

References 27 publications

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“…The estimated prevalence of the coinfection of HIV and HBV (0.32%), HBV and HCV (0.32%), as well as HIV and HCV (0.32%) in this study, were consistent with the reported magnitude of coinfection from a recent systematic review [45,46]. However, the magnitude of the triple infection in this study (0.00%) was different from the reported magnitude of the global magnitude of triple infection 1.29% [45,46]. The lower number of participants as compared with the above studies could be the possible reason for the observed variation because of the rare nature of the occurrence of triple infection requiring the large sample size to estimate the magnitude.…”

Section: The Prevalence Of Chronic Viral Infections In People With Sesupporting

confidence: 90%

Undiagnosed HIV, hepatitis B, and hepatitis C infections in people with severe psychiatric disorders in Ethiopia

Ayano

Haile²,

Tesfaye

et al. 2020

BMC Infect Dis

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Background: Worldwide, there is limited epidemiologic evidence on the seroprevalence of undiagnosed chronic viral infections including HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among patients with severe psychiatric disorders. To our knowledge, this is the first study to explore and compare undiagnosed seroprevalence rates of HIV, HBV, and HCV infections among patients with severe psychiatric disorders. Method: In this study, we included a random sample of 309 patients with severe psychiatric disorders selected by systematic sampling technique. We used a structured clinical interview for DSM-IV (SCID) to confirm the diagnosis of severe psychiatric disorders among the participants. Binary and multivariable logistic regression models, adjusting for the potential confounding factors was used to explore the potential determinants of chronic viral infections. Result: The prevalence estimates of HIV infection among patients with severe psychiatric disorders in this study (3.24%) was roughly 3 times the estimated population prevalence of HIV infection in Ethiopia (1.1%). This study showed that the prevalence rates of HBV and HCV infections among patients with severe psychiatric disorders were 4.85 and 1.29%, respectively. Our results also showed that among patients with chronic viral infections, HIV, HBV and HCV, 76.92, 60, 80, and 75% respectively were undiagnosed. Regarding associated factors, the presence of chronic viral infection was found to be significantly associated with the age of the participants (ranging between 30 and 40 years) after adjusting for the possible confounding factors [AOR = 3.95 (95%CI.18-13.17)]. Conclusion: Even though the prevalence estimates of HIV (3.24%), HBV (4.85%), and HCV (1.29%) infections were high among patients with severe psychiatric disorders, the majority of them remained undiagnosed. HBV was found to be the commonly undiagnosed infection (4 out of 5) followed by HCV (3 out of 4) and HIV (6 out of 10). The present study provided evidence of a significant association between the age of the participant (between 30 and 40 years) and chronic viral infections in patients with severe psychiatric disorders. Increasing the awareness of psychiatry professionals and early screening, as well as interventions of chronic viral infections among patients with severe psychiatric disorders are imperative.

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Section: The Prevalence Of Chronic Viral Infections In People With Sesupporting

confidence: 90%

Undiagnosed HIV, hepatitis B, and hepatitis C infections in people with severe psychiatric disorders in Ethiopia

Ayano

Haile²,

Tesfaye

et al. 2020

BMC Infect Dis

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“…[10] Among females, highest prevalence was found in age group of 51-60 (1.39%) years followed by 61-70 (1.15%) years and 41-50 (1.13%) years Similar results were noted by Patil et al and Quadri et al [13,14] In our study, co-infection of HBV and HCV was observed in 0.096% which was lower than that of Desikan et al (1.89%). [15] Of the total 214 HIV infected individuals included in our study, co-infection with HBV and HCV was found in 1.6% and 19.1% respectively. The higher prevalence rate of HCV in HIV positive patients in comparison to the rate for HBV positivity in HIV infected patients in our centre could be attributed to diverse factors such as increase in the rate of drug addiction, lack of vaccine for HCV.…”

Section: Discussionmentioning

confidence: 78%

Seroprevalence of Hepatitis B Virus Infection Among Patients Attending a Tertiary Care Centre in North-East India

Singh¹,

Singh²,

Singh³

et al. 2018

jemds

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BACKGROUND Hepatitis B infection is a major global health problem. The seroprevalence of Hepatitis B virus infection among general population attending at a tertiary care hospital is useful in assessing the magnitude of HBV infection and helps in devising preventive measures. The co-infection of Hepatitis B or Hepatitis C virus with HIV accelerates disease progression and may complicate the management of patients infected with HIV. This study was designed to determine hepatitis B virus infection among patients attending tertiary care centre in NorthEast India. MATERIALS & METHODS A total of 11399 serum samples, collected from patients attending outpatient or inpatient departments and ART centre, were screened for HBsAg using 3 rd generation ELISA (Qualisa HBsAg, Qualpro Diagnostics, Goa, India) in this retrospective study. RESULTS Seroprevalence of HBsAg was 1.23%. Seropositivity was seen more in males (2.2%) as compared to females (0.89%). Among males, highest occurrence was found in the age group of 21-30 (3.29%) years followed by 31-40 (2.94%) years and 41-50 (2.37%) years. Among females, highest prevalence was observed in age group of 51-60 (1.39%) years followed by 61-70 (1.15%) years and 41-50 (1.13%) years. CONCLUSION Present study showed that the overall rate of HBsAg positivity in our center was 1.23%. Males and younger age group were found to be more affected probably due to horizontal transmission.

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“…Precise study is limited regarding co-infected patients. One study by Desikan et 11 al, from India reported 1.89% co-infected with both virus . Hepatitis B virus (HBV) and hepatitis C virus (HCV) have several important similarities including worldwide distribution, hepato-tropism, similar modes of transmission and the ability to induce chronic infection that may lead to liver cirrhosis and hepatocellular carcinoma.…”

Section: Datamentioning

confidence: 99%

Spectrum of Hepatits B Infection Among Patients Attending Liver Unit in Nepalgunj Medical College – Kohalpur

Khadka¹,

Kc²,

Karki³

et al. 2018

J. Nepalgunj Med. College

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Introduction: Hepatitis B infection is a global problem. Hepatitis B virus (HBV) infection related liver disease is also not an uncommon problem in our country too. Reports regarding pattern of chronic HBV infection are also lacking. The aim of the present study was to determine the spectrum of chronic HBV infection among patients attending the liver clinic in a tertiary care center. Method: A hospital based descriptive cross-sectional study was carried out in Liver unit of Nepalgunj Medical College, Kohalpur, from April 2018 to November 2018. All patients with HBsAg positive were further tested for HBeAg, HBeAb, HBV DNA quantitative and liver function test. Ultrasound examination was advised for any evidence of chronic liver disease. Staging was done according to viral serology, liver biochemistry and ultrasonography of liver Results: Total patients enrolled were 119. Majority of patents were in between 30-60 years (51.3%) with male predominance 59.7%. Most of patients were in the stage of HBeAg negative chronic infection 66.4% with normal transaminase and HBV DNA <2000 IU/ML. Majority of patients having unknown source of infection 90.8%. Incidental detection (67.2%) was common mode of detection. Conclusions: Majority of patients were in HBeAg negative chronic hepatitis B infection phase with normal transaminase and low HBV DNA not requiring treatment.

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Prevalence of Hepatitis B and Hepatitis C Virus Co-infection in India: A Systematic Review and Meta-analysis

Cited by 24 publications

References 27 publications

Undiagnosed HIV, hepatitis B, and hepatitis C infections in people with severe psychiatric disorders in Ethiopia

Undiagnosed HIV, hepatitis B, and hepatitis C infections in people with severe psychiatric disorders in Ethiopia

Seroprevalence of Hepatitis B Virus Infection Among Patients Attending a Tertiary Care Centre in North-East India

Spectrum of Hepatits B Infection Among Patients Attending Liver Unit in Nepalgunj Medical College – Kohalpur

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