Prevalence of Hepatitis B Markers in Italy

Pasquini, Paolo; Kahn, Harold A.; Pileggi, D; Panà, Augusto; Terzi, J.; Guzzanti, Elio

doi:10.1093/oxfordjournals.aje.a113680

Cited by 66 publications

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“…Other countries (8)(9)(10)(11)(12) have also reported geographical variations of HBsAg seropositivity within their countries. Among them, the study from China (8) showed a higher positivity of HBsAg in coast areas, comparable with ones from Korea.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Findings of Hepatitis B Infection Based on 1998 National Health and Nutrition Survey in Korea

et al. 2002

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The purpose of this study was to investigate the epidemiological characteristics of hepatitis B virus (HBV) infection in Korea based on the 1998 National Health and Nutrition Survey. Study subjects consisted of 9,771 aged 10 yr or over, who were selected from across Korea using a stratified multistage probability sampling design. The prevalence of hepatitis B surface antigen (HBsAg) was compared by age, sex, residency, household income, education, family history, family size, and frequency of eating out. The prevalence of HBsAg was 5.1% (95% confidence interval (CI): 4.5-5.7) in males and 4.1% (95% CI: 3.6-4.6) in females with a low prevalence in those under 20 yr old. Generally, HBsAg seropositivity by administrative area was similar with the exception of Jeju province. HBsAg seropositivity of Jeju island was approximately three times higher in both men and women, as compared with the national average. HBsAg seropositivity by socioeconomic status unexpectedly showed a very consistent positive association in both gender. Comparing HBsAg seropositivity by the frequency of eating out, in both gender, the more frequent they ate out, the higher it was. Our study suggested that there might be another transmission route of HBV, which is possibly related to diet.

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Section: Discussionmentioning

confidence: 99%

Epidemiological Findings of Hepatitis B Infection Based on 1998 National Health and Nutrition Survey in Korea

et al. 2002

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“…We assessed only a few risk factors for low vaccine coverage and for acquiring chronic HBV infection. Other important factors such as low socioeconomic status and household crowding were not assessed [29][30][31][32][33]. Additionally, small numbers of HBsAg positive children limited stratification by receiving a birth dose and limited evaluation of the impact of ≥3 dose hepatitis B coverage.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia

Mao

Patel

Hennessey

et al. 2013

Vaccine

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“…A decrease in HBV, HDV and HCV endemicity in Italy has been shown in the past 2 decades, [29][30][31][32] but the present epidemiologic conditions still call for studies on multiple hepatitis infections.…”

Section: Discussionmentioning

confidence: 99%

Virologic and Clinical Expressions of Reciprocal Inhibitory Effect of Hepatitis B, C, and Delta Viruses in Patients With Chronic Hepatitis

et al. 2000

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Hepatitis B virus (HBV), hepatitis D virus (HDV), and hepatitis C virus (HCV) are responsible for the majority of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC) cases worldwide. 1-4 Multiple HBV and HDV infection has been extensively investigated in past years and found to be associated with a fulminant course of acute hepatitis, with the more severe forms of chronic liver disease, and with a rapid progression to liver cirrhosis. 5-8 An inhibitory effect exerted by HDV on HBV replication has also been shown. 9 The prevalence of patients with HCV and HBV coinfection has been described as high in geographic areas where a high endemic level of both infections is reported, such as Western Asia and the Mediterranean Basin. 10-14 The interaction between HCV and HBV has so far been poorly investigated. Little is known on the clinical presentation, the natural history, and the response to antiviral treatment of liver diseases associated with HBV and HCV coinfection. However, small pilot studies have prompted the hypothesis that HCV may have an inhibitory effect on HBV replication [15][16][17][18][19] and that multiple HBV and HCV infection may be associated with a more severe clinical presentation. 10,[20][21][22][23][24][25] The interaction between HDV and HCV in hepatitis B surface antigen (HBsAg) chronic carriers has not as yet been investigated.In this article we report the data from an Italian multicenter case-control study with incident cases, performed on a high number of patients with chronic hepatitis from a multiple hepatitis virus infection who were compared with patients with chronic hepatitis caused by a single virus. We investigated the interference between viruses, the clinical impact of a multiple virus infection compared with a single HBV or HCV infection, and tested the hypothesis that anti-HCV-positive/ anti-hepatitis B core antigen (HBc)-positive patients lacking both HBsAg and anti-hepatitis B surface antigen (HBs) might be a subgroup of patients with a multiple HBV and HCV infection. MATERIALS AND METHODSPatients. Seven liver units in different geographic areas of Italy, 1 in the north (Padua), 1 in the center (Rome), 2 in the south (Naples and Bari), 1 in Sardinia (Sassari), and 2 in Sicily (Palermo and Messina), participated in the study. These liver units had participated in numerous multicenter studies on chronic hepatitis in the past 2 decades and had been using similar criteria for the clinical approach and the histologic diagnosis. The investigation was planned as a cross-sectional case-control study with incident cases during a preliminary consensus meeting of the senior investigators from the participating centers.Chronic hepatitis was diagnosed on the basis of high serum transaminase values for at least 6 months.

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Prevalence of Hepatitis B Markers in Italy

Cited by 66 publications

References 0 publications

Epidemiological Findings of Hepatitis B Infection Based on 1998 National Health and Nutrition Survey in Korea

Epidemiological Findings of Hepatitis B Infection Based on 1998 National Health and Nutrition Survey in Korea

Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia

Virologic and Clinical Expressions of Reciprocal Inhibitory Effect of Hepatitis B, C, and Delta Viruses in Patients With Chronic Hepatitis

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