Prevalence of hepatitis B virus markers among blood donors in a tertiary hospital in Tabuk, northwestern Saudi Arabia

Beltagy, Kamel El; Balawi, Ibrahem A. Al; Almuneef, Maha; Memish, Ziad A.

doi:10.1016/j.ijid.2008.01.010

Cited by 55 publications

(61 citation statements)

References 15 publications

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“…This study detected lower HBsAg prevalence (0.8%) and lower prevalence of HBV infections (8.0%) among blood donors than had been previously reported in the southern region of the KSA [13,23], although one recent study in the Aseer province reported an HBsAg prevalence of as low as 1.03% [24]. Additionally, the cohort of donors between 16 and 21 years of age, whose birth corresponds with the HBV vaccine inclusion to EPI, showed no HBsAg and a low prevalence of HBV infections.…”

Section: Discussionsupporting

confidence: 50%

Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia

Almutairi

AlAhmari²,

Al-Zahran³

et al. 2016

J Infect Dev Ctries

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Introduction: Data on blood-borne viral infections in some regions in Saudi Arabia remain scarce. This study investigates the prevalence of serological markers and nucleic acid for blood-borne viruses among blood donors in Al-Baha, Kingdom of Saudi Arabia. Methodology: In this cross-sectional study, 2,807 donors who donated blood between January 2009 and November 2011 were investigated for blood-borne viral serological markers including HBsAg, anti-HBc, anti-HBs, anti-HCV, anti-HIV, and anti-HTLVI/III in addition to viral nucleic acid. Results: All donors were males between 16 to 66 years of age (mean: 31.5 ± 9.3 years). Viral nucleic acid and/or serological markers were detected in a total of 36 (1.3%) donors; of them, 26 (72.2%) had nucleic acid concomitant with serological markers, 6 (16.7%) had only viral nucleic acid, while 4 (11.1%) had only serological markers. Of all donors, 22 (0.8%) had HBsAg, 227 (8.0%) had anti-HBc, 157 (5.0%) had anti-HBs, 2,577 (91.8%) had no HBV markers, 2 (0.07%) had anti-HIV, 1 (0.04%) had anti-HCV, and 1 (0.04%) had anti-HTLVI/II. The donors who were born during HBV vaccination era showed no HBsAg (0.0%; p = 0.052), lower rates of anti-HBc (1.5%; p < 0.001) and antiHBs (0.7%; p < 0.001), while the majority had no HBV markers (98.5%; p < 0.001). Conclusions: Combined viral nucleic acid and serological testing of donated blood enhances blood safety. The absence of HBV markers among donors suggests susceptibility or declined anti-HBs levels. Thus, HBV revaccination or a vaccine boost among adolescents and adults might be indispensable.

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Section: Discussionsupporting

confidence: 50%

Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia

Almutairi

AlAhmari²,

Al-Zahran³

et al. 2016

J Infect Dev Ctries

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“…In that study, a family history suggestive of HBV infection, lack of HBV vaccination and low education levels were significantly associated with the development of HBV infection. [17] We suggest that future research should focus on clarifying HBV risk behaviors and transmission in this region, including modes of transmission within families and households.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B And Hepatitis C Seroprevalance In Center Of Sanliurfa Province From Souteastern Anatolia Region And Related Risk Factors

Koruk¹,

Koruk²,

Gursoy³

et al. 2009

TUTFD

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© Trakya Üniversitesi T p Fakültesi Dergisi. AVES Yay nc l k taraf ndan bas lm t r. Her hakk sakl d r. © Medical Journal of TrakyaObjective: The aim of this study was to evaluate the seroprevalence of HBV and HCV and related risk factors in Sanliurfa, a province of southeastern Anatolia. Material and Methods:This cross-sectional study was conducted between April and May, 2008 in Sanliurfa's city center. A community-based representative sample (N=1070) was randomly selected using cluster sampling from the catchment areas served by 19 different primary healthcare centers. A questionnaire evaluating demographic information and probable risk factors for HBV and HCV was administered, and HBsAg and anti-HCV markers were analyzed from blood samples.Results: Among the 1070 individuals who participated in the study, 33.1% were male (n=354) and 66.9% female (n=716). The average age was 35.4±13.5 (15-90) years. The seroprevalence of HBsAg positivity was 4.2% (n=45), while anti-HCV seropositivity was found to be 1.0% (n=11). Among participants who previously suffered a known hepatitis infection or who reported a family history of hepatitis, the HBsAg positivity was found to be higher (p<0.05). There was no statistically significant difference between HCV transmission risk factors and anti-HCV positivity.Conclusion: This is the first hepatitis seroprevalence study in central Sanliurfa and demonstrated moderate HBV infection endemicity.

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“…CHB is a leading cause of end-stage liver disease and hepatocellular carcinoma [2,3]. Saudi Arabia is similar to other CHB-endemic countries, where CHB is usually an outcome of vertical transmission or transmission early in life from infected family members [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Previously reported data on CHB from Saudi Arabia have focused on the prevalence of the disease [5][6][7] and the effect of HBV vaccination on reducing the rate of hepatitis B surface antigen (HBsAg) seropositivity in the country [9,10], but there are no similar data available that focus on the long-term follow-up or treatment outcome. HBV-DNA was found to be the best predictor of the severity of fibrosis, long-term outcome, progression to end-stage liver disease, the risk of hepatocellular carcinoma (HCC) and the response to therapy [2,3,[11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Chronic hepatitis B infection in a hepatology clinic at a university hospital in Jeddah

Fallatah

Akbar

2010

J Infect Dev Ctries

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Introduction: The outcome of chronic hepatitis B (CHB) infection in a cohort of CHB patients at the hepatology clinics of King Abdul Aziz University Hospital in Jeddah was studied. Methodology: The results of a complete blood count, prothrombin time, liver function test and hepatitis B virus polymerase chain reaction (HBV-PCR) performed over the previous two to five years of follow-up were reviewed. Results of abdominal ultrasound performed within the last year and the data on the treatment type, duration and resistance were also obtained. Results: The majority of the 109 patients studied were Hepatitis B e antigen (HBeAg-negative; 87.2%). Male patients had higher serum ALT values compared to females at follow-up. HBeAg-positive patients had higher HBV-PCR levels at diagnosis compared to HBeAgnegative patients. Patients below 40 years of age had higher HBV-PCR compared to those above 40 years. Ultrasound showed liver cirrhosis in 11% of patients. Cirrhotic patients had higher GGT levels compared to non cirrhotic patients. Drug resistance developed in 25% of the 20 Lamivudine-treated patients. The mean duration of treatment was 2.5 ± .47 years. Conclusion: CHB was predominantly HBeAg negative, with a benign long-term outcome in most patients. Therapy may need to be individualized for patients with high risk of progression.

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Prevalence of hepatitis B virus markers among blood donors in a tertiary hospital in Tabuk, northwestern Saudi Arabia

Cited by 55 publications

References 15 publications

Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia

Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia

Hepatitis B And Hepatitis C Seroprevalance In Center Of Sanliurfa Province From Souteastern Anatolia Region And Related Risk Factors

Chronic hepatitis B infection in a hepatology clinic at a university hospital in Jeddah

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