Prevalence of hepatitis C and hepatitis B virus infection(s) in patients with oral lichen planus

Jayavelu, Perumal; Sambandan, Thirumal

doi:10.4103/0975-7406.100302

Cited by 20 publications

(18 citation statements)

References 25 publications

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“…A study performed in Italian patients with OLP and HCV showed a statistically significantly higher frequency of human leukocyte antigen (HLA)‐DR6 in HCV patients compared with patients without HCV infection, suggesting that HCV‐positive patients with HLA‐DR6 are more prone to develop OLP lesions . It is estimated that patients with hepatitis C are twice as likely to develop LP than the general population . Figueiredo et al .…”

Section: Etiologymentioning

confidence: 99%

Oral lichen planus: an update on its pathogenesis

2015

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Section: Etiologymentioning

confidence: 99%

Oral lichen planus: an update on its pathogenesis

2015

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“…Exacerbation of lichen planus was described earlier in patients treated with recombinant interferon alfa-2a [16,17] and interferon alfa-2b [18] but also in those treated with pegylated interferon alfa [19]. It must be emphasized that one recent study showed no association of HCV and lichen planus in a series of 60 patients [20]. The recent introduction of direct-acting antivirals, telaprevir and boceprevir, as a part of a triple combination regimen has significantly widened the spectrum of the so-called uniform entity of dermatitis associated with peginterferon/ribavirin only [21].…”

Section: Discussionmentioning

confidence: 98%

Cutaneous Reactions in Patients with Chronic Hepatitis C Treated with Peginterferon and Ribavirin

Patrk¹,

Morović²,

Markulin³

et al. 2014

Dermatology

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Background/Objective: Peginterferon alfa and ribavirin could cause various cutaneous reactions. Treatment-related cutaneous reactions are common, and treatable complications can contribute to the treatment discontinuation. Methods: We performed a 6-year prospective study of cutaneous reactions in 271 patients with chronic hepatitis C treated with peginterferon and ribavirin. Results: Cutaneous reactions of mild to moderate degree were seen in 36 (13.3%) patients: localized cutaneous reactions in 7 (2.6%) patients, generalized reactions - pruritus, skin xerosis and eczematous changes - in 28 (10.3%) patients, alopecia in 11 (4.1%) patients; exacerbation of lichen planus was seen in 1 patient. Conclusion: The study showed a relatively low prevalence of cutaneous reactions without the need for discontinuation of any of the drugs used. These reactions correlated only with the age of the patients and treatment duration. This finding is of particular importance with regard to the recently introduced direct-acting antivirals in the treatment of hepatitis C virus infection, which can cause a very severe form of cutaneous reactions.

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“…16,17 No concrete association between LP and HCV was detected in India. 8,9,13,18 Hepatitis B virus (HBV) has also been shown to have a causal association in LP cases. 1,19,20 Other viruses which have been implicated in the pathogenesis of LP include human herpesvirus-6 and human herpesvirus-7 and varicella zoster virus.…”

Section: Various Studies Editorials and Meta-analyses Have Demonstramentioning

confidence: 99%

“…[2][3][4][5][6] Many reports have shown contrasting results to this which has been attributed to various factors ranging from genetics to regional differences. [7][8][9][10] Another reason for these contrasting results is that many have included clinically diagnosed cases of lichen planus without histological confirmation which may lead to erroneous results as we know many lichenoid disorders can mimic lichen planus. Lichen planus is still quoted when chapters are written about the possible association with Hepatitis B and C virus.…”

Section: Introductionmentioning

confidence: 99%

“…1,11,12 Few studies have been done in India to study this association and the guidelines regarding the testing of hepatitis B and C in all cases of LP are not available. 9,10,13 This study was undertaken to determine the prevalence of hepatitis B and hepatitis C infections in histologically proven lichen planus cases in this part of the world and to understand whether testing for hepatitis B and C in cases of LP may benefit the patient.…”

Section: Introductionmentioning

confidence: 99%

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Zero prevalence of hepatitis B and hepatitis C infections in clinicopathologically proven lichen planus cases: a cross sectional study at a tertiary care centre in south India

et al. 2017

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INTRODUCTIONLichen planus (LP), which was first described by Jonathan Hutchinson in 1869, is a common chronic mucocutaneous inflammatory disorder of unknown etiology. It has characteristic clinical and pathological features affecting the skin, mucus membrane, nails, and hair. LP can present in many forms like actinic, annular, atrophic, erosive, follicular (lichen planopilaris), guttate, hypertrophic, linear, papular and vesiculobullous. Skin lesions are typically characterized by a white lace-like pattern (Wickham's striae) on papules, which is pathognomonic. Lesions may be confined to the mouth, or with minimal accompanying skin involvement, accounting for almost 15% of all cases.1 A clinically suspected case of LP may be confirmed histologically by a simple skin biopsy. ABSTRACTBackground: Lichen planus (LP) is a common chronic mucocutaneous inflammatory disorder of unknown etiology. Several editorials, chapters, studies have suggested an association between hepatitis C virus and hepatitis B virus (to a lesser extent) in LP. This association was not seen in various parts of the world including India. Methods: Patients attending the dermatology outpatient department with lichen planus confirmed by histopathologic examination were included in the study and along with clinic-epidemiological data, all the patients were tested for hepatitis B and hepatitis C infection. Results: A total of 84 patients of clinico-pathologically proven lichen planus were included in the study out of which 31 were males and 53 were females. The most common age group of lichen planus in our study group was 40-50 years. Major histopathological findings were basal cell degeneration (92.7%), hyperkeratosis (89%), pigment incontinence (73%) and lymphohistiocytic infiltration (70%). All patients in this study group tested negative for HBsAg and anti-HCV antibodies. Conclusions: Although numerous studies around the world have suggested an association between HCV and HBV infections with lichen planus-multiple subsequent studies including the present study shows contrasting results especially in this part of the world. The authors believe routine screening of lichen planus patients for presence of hepatitis B and hepatitis C infection is not warranted, particularly in Indian population.

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Prevalence of hepatitis C and hepatitis B virus infection(s) in patients with oral lichen planus

Cited by 20 publications

References 25 publications

Oral lichen planus: an update on its pathogenesis

Oral lichen planus: an update on its pathogenesis

Cutaneous Reactions in Patients with Chronic Hepatitis C Treated with Peginterferon and Ribavirin

Zero prevalence of hepatitis B and hepatitis C infections in clinicopathologically proven lichen planus cases: a cross sectional study at a tertiary care centre in south India

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