Prevalence of hepatitis C infection and risk factors in hospitalized diabetic patients: results of a cross-sectional study

Cadranel, Jean–François; Martino, Vincent Di; Lambrey, G; Mourlhon, C; Nalet, Bernard; Anciaux, Marie-Laure; Richard, Christian; Bigué, Jean-Paul; Barjon, Jean-Noël; Bories, Christian; Barbare, Jean‐Claude; Halimi, C.; Ribiere, O.; Eugène, C; Pauwels, Arnaud; Jeanne, Sandrine; Donato, Laurence; Dumouchel, Patrice; Pariente, Alexandre; Duverlie, Gilles; Devergie, B; Arlot, S; Capron, Dominique

doi:10.1097/meg.0b013e3282fc73a1

Cited by 26 publications

(20 citation statements)

References 34 publications

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“…These cohorts included individuals in health-care settings as part of case-control studies or convenience sampling. Such settings are associated with transmission of HCV due to potential nosocomial transmission through fomites or non-exposure prone procedures including venepuncture and cannulation, 14,[24][25][26] and might explain why recorded prevalence was higher than in population surveys.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C seroprevalence and HIV co-infection in sub-Saharan Africa: a systematic review and meta-analysis

Rao

Johari

Cros

et al. 2015

The Lancet Infectious Diseases

119

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CitationHepatitis C seroprevalence and HIV co-infection in subSaharan Africa: a systematic review and meta-analysis. SummaryBackground An estimated 150 million people worldwide are infected with hepatitis C virus (HCV). HIV co-infection accelerates the progression of HCV and represents a major public health challenge. We aimed to determine the epidemiology of HCV and the prevalence of HIV co-infection in sub-Saharan Africa.

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Section: Discussionmentioning

confidence: 99%

Hepatitis C seroprevalence and HIV co-infection in sub-Saharan Africa: a systematic review and meta-analysis

Rao

Johari

Cros

et al. 2015

The Lancet Infectious Diseases

119

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“…24 The risk of a nosocomial HCV infection in hospitalized diabetic patients has been reported to be associated with frequent transfusions, blood sampling, intravenous drug use, being treated in a hepatogastroenterology center and a high number of previous admissions after the onset of diabetes. 25 Disturbances in humoral and cellular immunity in patients with DM may contribute to the high risk of HCV infection. Owing to an immunosuppressed status, T2DM may be involved in impaired HCV clearance.…”

Section: Discussionmentioning

confidence: 99%

Impact of HCV Infection on Diabetes Patients for the Risk of End-Stage Renal Failure

Hwang

Jiang

et al. 2016

Medicine

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Both diabetes mellitus (DM) and hepatitis C virus infection (HCVI) are associated with chronic kidney disease (CKD). The aim of this study was to evaluate whether HCVI increases the risk of end-stage renal disease (ESRD) in patients with DM.The National Health Insurance Research database of Taiwan was used to conduct this study. After excluding patients with a prior history of CKD, all patients with a first diagnosis of DM from January 1, 2000 to December 31, 2002 were enrolled. The patients who also had HCVI were defined as index cases (HCV group, n = 9787). A comparison cohort at a 1:1 ratio of random incident patients with DM without HCVI matched by age, sex, age at the diagnosis of DM, duration between the diagnosis of DM and the index date, and various comorbidities through propensity score matching were recruited (non-HCV group, n = 9787). The patients were followed until December 31, 2011.The cumulative incidence rate of developing ESRD was significantly higher in the HCV(+) group than in the non-HCV group (P = 0.008). The incidence rate ratio (IRR) for the risk of ESRD was also significantly higher in the HCV(+) group (IRR: 1.44; 95% CI: 1.09–1.89) than in the non-HCV group, especially for those with a younger age (<50 years; IRR: 2.05; 95% CI: 1.22–3.45) and HCVI within 4 years after the diagnosis of DM (IRR: 1.85; 95% CI: 1.16–2.97). After adjusting for comorbidities in multivariate Cox proportional hazard regression analysis, HCVI (HR: 1.47; 95% CI: 1.11–1.93) was an independent factor for developing ESRD in the patients with DM. After starting dialysis for ESRD, the HCV(+) patients had a similar mortality rate to those without HCVI (P = 0.84).HCVI increases the risk of developing ESRD in patients with DM, especially in younger patients and in those who develop HCVI sooner after a diagnosis of DM.

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“…The prevalence of HCV infection among diabetic subjects ranges from 2 to 11.5% (12-14) and seems to be unrelated to hepatic fibrosis grade or to the presence of cirrhosis. HCV infection appears to precede the development of type 2 DM (10).…”

Section: Introductionmentioning

confidence: 99%

Clinical features of patients with type 2 diabetes mellitus and hepatitis C infection

Greca

Pinto

Rados

et al. 2012

Braz J Med Biol Res

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The objective of the present cross-sectional study was to assess the prevalence and the clinical and laboratory features of hepatitis C virus (HCV)-positive patients with type 2 diabetes mellitus (DM) attending either an outpatient clinic or hemodialysis units. Serologic-HCV testing was performed in 489 type 2 DM patients (303 outpatients and 186 on dialysis). A structured assessment of clinical, laboratory and DM-related complications was performed and the patients were then compared according to HCV infection status. Mean patient age was 60 years; HCV positivity (HCV+) was observed in 39 of 303 (12.9%) outpatients and in 34 of 186 (18.7%) dialysis patients. Among HCV+ patients, 32 were men (43.8%). HCV+ patients had higher serum levels of aspartate aminotransferase (0.90 ± 0.83 vs 0.35 ± 0.13 μKat/L), alanine aminotransferase (0.88 ± 0.93 vs 0.38 ± 0.19 μKat/L), gamma-glutamyl transferase (1.57 ± 2.52 vs 0.62 ± 0.87 μKat/L; P < 0.001), and serum iron (17.65 ± 6.68 vs 14.96 ± 4.72 μM; P = 0.011), and lower leukocyte and platelet counts (P = 0.010 and P < 0.001, respectively) than HCV-negative (HCV-) patients. HCV+ dialysis patients had higher diastolic blood pressure than HCV- patients (87.5 ± 6.7 vs 81.5 ± 6.0 mmHg; P = 0.005) and a lower prevalence of diabetic retinopathy (75 vs 92.7%; P = 0.007). In conclusion, our study showed that HCV is common among subjects with type 2 DM but is not associated with a higher prevalence of chronic diabetic complications.

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Prevalence of hepatitis C infection and risk factors in hospitalized diabetic patients: results of a cross-sectional study

Abstract: A nosocomial source of HCV infection in hospitalized diabetic patients is suggested by the increased risk of HCV infection associated with the number of hospitalizations. This may account for at least 36% of cases of HCV infection.

Cited by 26 publications

References 34 publications

Hepatitis C seroprevalence and HIV co-infection in sub-Saharan Africa: a systematic review and meta-analysis

Hepatitis C seroprevalence and HIV co-infection in sub-Saharan Africa: a systematic review and meta-analysis

Impact of HCV Infection on Diabetes Patients for the Risk of End-Stage Renal Failure

Clinical features of patients with type 2 diabetes mellitus and hepatitis C infection

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