Prevalence of Hepatitis C Virus Infection in Different Population Groups in Southern Italy

Montella, Maurizio; Crispo, Anna; Grimaldi, Maria; Angeletti, Claudio; Amore, Alfonso; Ronga, Domenico; Sabbatini, Massimo; Pisani, Antonio; Spiteri, D.; Serraino, Diego

doi:10.1007/s15010-005-9205-8

Cited by 7 publications

(7 citation statements)

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“…These inconsistencies could be partially due to differences in the study populations. The prevalence of HBV and/or HCV (11.4%) was much higher in our control group, as it averaged the HCV prevalence registered in Naples (13% in general practitioner patients aged 50-65 years, peaking to 20% in people aged over 65 years) 31 and in Pordenone (3.2%). 32 A Japanese cohort study 15 reported about 70% reduction of HCC risk for subjects who drunk 5 cups/day.…”

Section: Discussionsupporting

confidence: 41%

Coffee and tea consumption and risk of hepatocellular carcinoma in Italy

Montella

Polesel

Vecchia

et al. 2007

Intl Journal of Cancer

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The role of coffee in the aetiology of hepatocellular carcinoma has raised great interest. In Italy, coffee consumption is high, thus allowing the investigation of the topic over a broad range of consumption. A hospital-based case-control study was conducted in Italy in [1999][2000][2001][2002], including 185 incidents, histologically confirmed cases of hepatocellular carcinoma aged 43-84 years. Controls were 412 subjects admitted to the same hospitals' networks for acute, non-neoplastic diseases unrelated to diet. Coffee and tea consumption were assessed using a validated food-frequency questionnaire. Odds ratios (ORs) and corresponding the 95% confidence intervals (CI) were computed using unconditional multiple logistic regression, adjusting for hepatitis viruses seropositivity, alcohol intake, smoking habits and other potential confounding factors. Compared to people who drunk <14 cups/week of coffee, the risk of hepatocellular carcinoma decreased for increasing levels of consumption (OR 5 0.4, 95% CI: 0.2-1.1 for 28 cups/week, p for trend 5 0.02). In the present study, inverse relations were observed across strata of hepatitis C and B virus infections and alcohol drinking. No significant association emerged with consumption of decaffeinated coffee (OR 5 0.7, 95% CI 5 0.2-2.5) or tea (OR 5 1.4, 95% CI 5 0.8-2.7). The present study supports the hypothesis of a favourable effect of coffee, though not decaffeinated coffee and tea, on the risk on hepatocellular carcinoma. ' 2006 Wiley-Liss, Inc.Key words: coffee; tea; hepatocellular carcinoma; case-control study Hepatocellular carcinoma (HCC) is a highly fatal cancer that, in Italy, accounts for 3.4% of all newly diagnosed cancers among men and for 1.9% among women. 1 Likewise, the burden of HCC on total cancer mortality was 4.4% among men and 2.7% among women. 2 Incidence and mortality have shown upward trends in most of the developed countries, 3-5 including Italy. 3 The major known risk factors are persistent infections with hepatitis C virus (HCV) and hepatitis B virus (HBV), 6 but other prevalent medical conditions (i.e., liver cirrhosis) or socio-demographic factors, such as alcohol drinking and tobacco smoking, may play an important role in HCC onset. 6,7 Several studies from Europe, Japan, and United States reported an inverse relation between coffee consumption, g-glutamyltransferase (GGT) 8-10 and alanine aminotransferase (ALT) 10,11 levels, which are markers of liver injuries. Recently, increasing evidence has emerged on the relation between coffee drinking and risk of cirrhosis 12-14 and HCC. [15][16][17][18] A consistent inverse association with coffee consumption against HCC was found in cohort 15,[17][18][19] and case-control studies. 16,20,21 A few studies have investigated tea consumption in relation to HCC incidence and mortality, 14,15,19,22 and their results were inconclusive.Italy ranked among the top European countries according to annual pro-capite consumption of coffee (about 6 kg) (www.ico.org). The present paper, based on a case-control ...

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Section: Discussionsupporting

confidence: 41%

Coffee and tea consumption and risk of hepatocellular carcinoma in Italy

Montella

Polesel

Vecchia

et al. 2007

Intl Journal of Cancer

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“…Montella and others suggested that illicit intravenous drug use is a major transmission route for HCV infection in younger people and that iatrogenic transmission via nonsterile syringes is a major route of transmission in older age groups. 19 Given that three of four of our study subjects were less than 30 years of age, it is likely that the absence of IDUs accounts for the lower HCV seroprevalence in our study compared with that in other studies.…”

Section: Discussionmentioning

confidence: 58%

Seroprevalence and Risk Factors for Hepatitis C Virus Infection Among Female Commercial Sex Workers in South Korea Who Are Not Intravenous Drug Users

Kweon

Shin²,

Song³

et al. 2006

The American Journal of Tropical Medicine and Hygiene

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Several previous studies have reported a high prevalence of hepatitis C virus (HCV) infection among commercial sex workers (CSWs), but the situation is often compounded by coexisting factors, such as intravenous drug use. We conducted a seroepidemiologic study of 1,527 female CSWs in South Korea. All participants tested negative for human immunodeficiency virus and were not illicit intravenous drug users (IDUs). Twenty-one participants (1.4%) were positive for antibodies to HCV. According to the multivariate logistic regression analysis, a history of acupuncture and diabetes mellitus were associated with the seroprevalence of HCV, whereas time spent as a CSW showed only borderline significance. Sexual activity was not an independent predictor of increased risk for HCV infection in female CSWs who had never been illicit IDUs.

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“…As a result of improved blood transfusion safety serotypes associated with blood transfusions are being replaced by other serotypes especially those related to injecting drug use [44]. Prisoners often have prevalence rates of antibodies to HCV comparable to those of IDUs due to a high proportion of IDUs among this group [46][47][48][49][50][51][52][53][54]. In Germany, Spain and in UK the anti-HCV prevalence in sex workers ranged from 0.7 to 9.0 %; with the lowest estimate in Germany [20,23,24].…”

Section: T a B L E 4 Characteristics Of Hepatitis C Surveillance Systmentioning

confidence: 99%

Surveillance and epidemiology of hepatitis B and C in Europe – a review

2008

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Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are frequent causes of acute and chronic hepatitis worldwide and leading causes for hepatic cirrhosis and cancer. There is a distinct geographical variation in HBV and HCV incidence and prevalence in the European Union (EU) and European Economic Area/European Free Trade Association (EEA/EFTA) member states and neighbouring countries. The HBV carrier prevalence ranges from 0.1 to 8.0% and that of HCV from 0.1 to 6.0%. Within the last few years, the HBV incidence has decreased while the HCV incidence has increased. Both diseases are concentrated in certain subpopulations, such as injecting drug users, with tens of times higher prevalence than in the general population. Most EU and EEA/EFTA countries have a surveillance system for HBV and HCV infections, but due to differences in system structures, reporting practices, data collection methods and case definitions used, the surveillance data are difficult to compare across countries. The harmonisation and strengthening of HBV and HCV surveillance at the European level is of utmost importance to obtain more robust data on these diseases.

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Prevalence of Hepatitis C Virus Infection in Different Population Groups in Southern Italy

Cited by 7 publications

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Coffee and tea consumption and risk of hepatocellular carcinoma in Italy

Coffee and tea consumption and risk of hepatocellular carcinoma in Italy

Seroprevalence and Risk Factors for Hepatitis C Virus Infection Among Female Commercial Sex Workers in South Korea Who Are Not Intravenous Drug Users

Surveillance and epidemiology of hepatitis B and C in Europe – a review

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