Prevalence of Hepatitis C Virus Antibodies and Evaluation of Hepatitis C Virus Genotypes in Patients with Lichen planus

Abstract

Background: Several cases of lichen planus (LP) associated with hepatitis C virus (HCV) infection have been described. The reported prevalence rates of anti-HCV in patients with LP show wide geographical variations. An association of HCV-associated disorders with certain HCV geno/subtypes has not been investigated so far. Objective: The aim of the present study was to define the prevalence rate of anti-HCV in German patients with LP and to determine the distribution of HCV geno/subtypes. Methods: All patients with LP of the present study (n = 84) were tested for anti-HCV antibodies by an enzyme-immunoassay (second generation). HCV RNA was detected by reverse-transcription polymerase chain reaction (RT-PCR) and HCV geno/subtyping was performed by the reverse hybridization assay. Serum samples of 87 patients with various cutaneous diseases excluding LP served as control group. Results: Anti-HCV antibodies were detected in 13/84 patients with LP (16%), and 12/13 anti-HCV-positive patients were viraemic as assessed by the presence of HCV RNA. Most patients were infected with subtype HCV-1b (10/12 patients), while the 2 remaining patients were infected with HCV-2b and HCV-3a, respectively. In the control group, anti-HCV antibodies were only observed in 1/87 patients (1.1%), infected with subtype HCV-1b. Conclusion: The statistically significant (p < 0.002) high prevalence of HCV RNA in patients with LP is suggestive of an aetiological role of HCV in the pathogenesis of LP. Compared to the geno/subtype distribution of patients with chronic hepatitis C without LP of the same geographical area, no convincing correlation between geno/subtype and the presence of LP was obtained.

Associação entre líquen plano e o vírus da hepatite C: Um estudo de metanálise

“…A 24 Inglaterra, 25 Eslovênia, 10 Japão 16 e Ín-dia. 17 Três trabalhos foram conduzidos na Itália, 6,20,22 entretanto, como Campisi et al 20 analisaram duas diferentes regiões da Itália (Campania e Sicilia), este estudo aparece dividido, de acordo com as regiões, para melhor entendimento e visualização dos resultados, recebendo as numerações 10 e 11 respetivamente.…”

“…Outro estudo 18 excluiu todos os pacientes com LP que tinham possibilidade de reação liquenóide por uso de drogas ou restauração dental. A presença dos anticorpos anti -HCV dos estudos foi confirmada, na maioria dos casos, por RIBA de segunda geração, 6,[19][20][21][22] 6,16,18,20,23,24 No estudo realizado no Irão, 18 os pacientes do grupo controle foram avaliados por dois dentistas para excluir lesões de LP e foram avaliados quanto ao passado ou história de hepatite viral, risco de contaminação, cirurgia prévia, consumo de álcool, uso de drogas intravenosa, história de tatuagem, abuso de drogas entre outros.…”

“…Os pacientes com LP eram, em sua maioria, compostos por mulheres em treze dos dezasseis estudos, 6,10,[15][16][17][18][19][20]22,[24][25][26][27] enquanto que os homens foram maioria, no grupo de LP, em um deles, 21 sendo que um estudo não quantificou a relação de homens e mulheres nesse grupo. 23 Em relação ao grupo controle, as mulheres também foram maioria em oito dos trabalhos, 10 …”

Hepatitis C – related diseases

“…Az elôfordulás gyakorisága földrajzilag igen eltérô: Észak-Európában 1%, Egyiptomban 15% felett, átlag 4,8%. Több vizsgáló közvetlen patológiai összefüggést lát az erozív szájnyálkahártya lichen, a lichen ruber planus disseminalt formája és a HCV fertôzés között (3,(44)(45)(46).…”

Zero prevalence of hepatitis B and hepatitis C infections in clinicopathologically proven lichen planus cases: a cross sectional study at a tertiary care centre in south India

“…[2][3][4][5][6] Many reports have shown contrasting results to this which has been attributed to various factors ranging from genetics to regional differences. [7][8][9][10] Another reason for these contrasting results is that many have included clinically diagnosed cases of lichen planus without histological confirmation which may lead to erroneous results as we know many lichenoid disorders can mimic lichen planus.…”