Prevalence of hepatitis C virus in young people who inject drugs in four Colombian cities: A cross-sectional study using Respondent Driven Sampling

Toro-Tobón, David; Fernández, Dedsy Yajaira Berbesí; Mateu‐Gelabert, Pedro; Segura-Cardona, Ángela; Montoya-Vélez, Liliana Patricia

doi:10.1016/j.drugpo.2018.07.002

Cited by 8 publications

(6 citation statements)

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“…was the main risk factor [16], and a cross-sectional study with 918 PID from four Colombian cities (Armenia, Bogotá, Cúcuta and Pereira) found a prevalence of 27.3% in HCV, and the risk factors were: had a history of injection drug use of 5 years or more, higher injection frequency, daily use of gifted, sold, or rented needles and being HIV seropositive [17].…”

Section: Introductionmentioning

confidence: 99%

“…In indigenous populations of the Colombian Amazon the prevalence of HBV (using anti-HBc) was 3.6% (46/1275) in children and 30.9% (177/572) in mothers; genetic studies in the positives cases showed a predominance of subgenotypes F1b and F1a, with identification of two HBV escape mutants G145R and W156* in a child with occult HBV; mutations L109R and G130E of the HBsAg sequence were also identified [ 15 ]. Specifically in people who inject drugs (PID), a study about HIV/HCV which included 50 people from Pereira-Colombia shown that had sex with other key groups was the main risk factor [ 16 ], and a cross-sectional study with 918 PID from four Colombian cities (Armenia, Bogotá, Cúcuta and Pereira) found a prevalence of 27.3% in HCV, and the risk factors were: had a history of injection drug use of 5 years or more, higher injection frequency, daily use of gifted, sold, or rented needles and being HIV seropositive [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of hepatitis B/C viruses and associated factors in key groups attending a health services institution in Colombia, 2019

2020

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Both hepatitis B virus (HBV) and hepatitis C virus (HCV) are major sources of morbidity and mortality worldwide; however, their prevalence in key groups in Colombia is not yet known. We aimed to analyse the prevalence of HBV and HCV and its associated factors in key groups who were treated at an institution providing health services in Colombia during 2019. This was a multiple-group ecological study that included 2,624 subjects from the general population, 1,100 men who have had sex with men (MSM), 1,061 homeless individuals, 380 sex workers, 260 vulnerable young people, 202 drug users, 41 inmates and 103 people from the lesbian, gay, bisexual and transgender community. Prevalence of infection with a 95% confidence interval and its associated factors was calculated for each group. Confounding variables were assessed using logistical regression and SPSS 25.0 software. Prevalence of HBV and HCV in the general population was 0.15% and 0.27%, respectively; 0.27% and 2.09% in MSM; 0.37% and 2.17% amongst homeless individuals; 0.26% and 0.0% amongst sex workers; 0.39% and 0.0% amongst vulnerable youth; and 5.94% and 45.54 amongst injecting drug users. In the multivariate HBV model, the explanatory variables included the study group, city of origin and the type of health affiliation; for HCV they were group, origin, sex, age group, health affiliation, use of drugs and hallucinogen use during sexual intercourse. A high prevalence of HBV and HCV were evidenced for both viral infections, which was, consequently, much higher within the key groups. The main associated factors that were identified related to origin and type of health affiliation and demonstrated a double vulnerability, that is, belonging to groups that are discriminated and excluded from many health policies and living under unfavourable socioeconomic conditions that prevent proper affiliation and health care.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of hepatitis B/C viruses and associated factors in key groups attending a health services institution in Colombia, 2019

2020

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“…La edad promedio de los participantes del estudio fue de 26,3 ± 6,5 años, y la frecuencia de infección por VHC fue de 28,8 % con un rango entre 7,6 % (Bogotá) y 47,4% (Pereira) según la ciudad. El riesgo de infección por VHC estuvo asociado al uso de drogas inyectables durante cinco años o más (OR = 3,1; IC95%: 1,3-7,2) ( 35 , 36 ). La coinfección de VHC y VIH en esta población fue de 3,2%, con un rango de 1% en Bogotá a 5,6% en Pereira ( 36 ).…”

Section: Resultsunclassified

“…En PID se han realizado varios estudios en diferentes regiones del país con un rango de seroprevalencia entre 7,6% y 47,4% (cuadro 1) (28,(33)(34)(35)(36). En un importante estudio realizado en 1 123 PID en cinco ciudades del país (Bogotá, Medellín y Cúcuta −en la frontera con Venezuela− y Pereira y Armenia en la región andina-eje cafetero) se describe la infección por VHC.…”

Section: Resultsunclassified

Epidemiología de la infección por el virus de la hepatitis C en Colombia

Lopez-Osorio

Beltrán

Navas

2021

Revista Panamericana De Salud Pública

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Objetivo. Describir la epidemiología de la infección por el virus de la hepatitis C (VHC) en Colombia. Métodos. Revisión crítica de los estudios de epidemiología de la infección por VHC en Colombia mediante búsqueda de artículos originales y revisiones de tema publicados en el período 1989 a 2020 en las bases de datos PubMed, SciELO y ScienceDirect. Además, se revisaron los informes del Instituto Nacional de Salud y de la Cuenta de Alto Costo del Ministerio de Salud y Protección Social. Resultados. Los datos de seroprevalencia de anticuerpos anti-VHC en donantes de sangre están en un rango de 1,5% a 0,32%, que corresponden a los informes del inicio y el final del período de estudio, respectivamente. En la población con factores de riesgo se observa una alta prevalencia de infección por VHC, aunque con variaciones a lo largo del tiempo. Con respecto a los genotipos de VHC en Colombia, se han identificado los genotipos 1, 2, 3 y 4 (subgenotipos 1a, 1b, 2a y 3a). Conclusiones. En el período de observación, se describe una disminución en la seroprevalencia de la infección por VHC en donantes de sangre y en pacientes en tratamiento con hemodiálisis en Colombia, lo que demuestra el impacto de las políticas de sangre segura y las medidas de bioseguridad. Los estudios en personas que usan drogas ilícitas por vía inyectable indican una alta prevalencia de infección, con diferencias según la región del país. El genotipo 1, subgenotipo 1b, del VHC es el más frecuente en los distintos estudios realizados en Colombia, y el informe más reciente de la Cuenta de Alto Costo del Ministerio de Salud y Protección Social señala que el genotipo 4 es el segundo genotipo más frecuente en el país.

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“…irrespective of the varied study designs and the very characteristics of RDS, especially the underlying network structures (e.g., Do et al, 2018;Liu et al, 2018;Toro-Tobón, Berbesi-Fernandez, Mateu-Gelabert, Segura-Cardona, & Montoya-Vélez, 2018). Conversely, others try to use some form of weighted logistic regression, adding weights obtained from reported network sizes (e.g., Hotton, Quinn, Schneider, & Voisin, 2018;Ndori-Mharadze et al, 2018;Szwarcwald et al, 2018).…”

mentioning

confidence: 99%

Assessing logistic regression applied to respondent-driven sampling studies: a simulation study with an application to empirical data

Sperandei

Bastos

Ribeiro-Alves

et al. 2022

International Journal of Social Research Methodology

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Objective: To investigate the impact of different logistic regression estimators applied to RDS samples obtained by simulation and real data. Methods: Four simulated populations were created combining different connectivity models, levels of clusterization and infection processes. Each subject in the population received two attributes, only one of them related to the infection process. From each population, RDS samples with different sizes were obtained. Similarly, RDS samples were obtained from a real-world dataset. Three logistic regression estimators were applied to assess the association between the attributes and the infection status, and subsequently the observed coverage of each was measured. Results: The type of connectivity had more impact on estimators' performance than the clusterization level. In simulated datasets, unweighted logistic regression estimators emerged as the best option, although all estimators showed a fairly good performance. In the real dataset, the performance of weighted estimators presented some instabilities, making them a risky option. Conclusion: An unweighted logistic regression estimator is a reliable option to be applied to RDS samples, with similar performance to random samples and, therefore, should be the preferred option.

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Prevalence of hepatitis C virus in young people who inject drugs in four Colombian cities: A cross-sectional study using Respondent Driven Sampling

Cited by 8 publications

References 45 publications

Prevalence of hepatitis B/C viruses and associated factors in key groups attending a health services institution in Colombia, 2019

Prevalence of hepatitis B/C viruses and associated factors in key groups attending a health services institution in Colombia, 2019

Epidemiología de la infección por el virus de la hepatitis C en Colombia

Assessing logistic regression applied to respondent-driven sampling studies: a simulation study with an application to empirical data

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