Prevalence of Hepatitis E Virus (HEV) Antibodies in Sheep from Sokoto State

Shuaibu, Abdulmalik Bello; Alkali, B. R.; Abubakar, Mustapha; Daneji, A. I.; Shuaibu, S; Bello, Ana Cristina Passos de Paiva; Abubakar, F; Bello, Mercedes Castro

doi:10.9734/jamb/2016/31378

Cited by 5 publications

(5 citation statements)

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“…The seroprevalence detected in sheep was 2.1% (5/240; 95%CI: 0.3–3.9), which is similar to those previously observed in north‐eastern Spain (2.6%) (Peralta et al., 2009) and in Egypt (4.4%) (El‐Tras et al., 2013). Higher seropositivity values were found in China (9.8%) (Chang et al., 2009), Burkina Faso (12.0%) (Ouoba et al., 2019), Jordan (12.7%) (Obaidat & Roess, 2020), Portugal (16.6%) (Mesquita et al., 2020), Italy (21.3%–21.6%) (Palombieri et al., 2020; Sarchese et al., 2019), Nigeria (31.8%) (Shuaibu et al., 2016), Turkmenistan (42.0%) (Favorov et al., 1998) and India (77.6%–100%) (Shukla et al., 2007). Contrasting with this, previous studies failed to detect anti‐HEV antibodies in both sheep and goats from Brazil and India (Arankalle et al., 2001; Vitral et al., 2005).…”

Section: Resultsmentioning

confidence: 99%

Epidemiological survey and risk factors associated with hepatitis E virus in small ruminants in southern Spain

Caballero‐Gómez

García‐Bocanegra

Jiménez‐Martín

et al. 2022

Zoonoses and Public Health

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Autochthonous cases of hepatitis E (HE) associated with zoonotic genotypes HEV-3 and HEV-4 have significantly increased in industrialized countries over the last decade. Suidae are generally recognized as the main reservoirs of these genotypes.Susceptibility to HE virus (HEV) infection and zoonotic potential have also been confirmed in other species, including sheep and goat. However, the information about their role in the epidemiology of HEV remains very scarce. The objective of this study was to assess the prevalence, spatial distribution and risk factors associated with HEV exposure in sheep and goats in southern Spain, the country with the highest census of small domestic ruminants in the European Union. Blood samples from 240 sheep and 240 goats were collected between 2015 and 2017. Sera were analysed in parallel using a commercial double-antigen ELISA and real-time PCR. A total of 38 (7.9%; 95%CI: 5.5-10.3) out of 480 sampled animals showed anti-HEV antibodies. By species, the seroprevalences found in sheep and goats were 2.1% (5/240; 95%CI: 0.3-3.9) and 13.8% (33/240; 95%CI: 9.4-18.1) respectively. Anti-HEV antibodies were found on 19 (59.4%;) of the 32 sampled farms. The GEE model showed that species (goat) and number of small ruminants in the farm (≤348 animals and ≥538 animals) were risk factors potentially associated with HEV exposure in small ruminants in the study area. HEV RNA was not detected in any of the 480 (0.0%; 95%CI: 0.0-0.8) tested animals. Our results confirm that sheep and goats are naturally, but not equally exposed to HEV and indicate the widespread spatial distribution of HEV among small ruminant populations in southern Spain. Further studies are required to elucidate the role of sheep and goat in the epidemiology of HEV and their potential implications for public health.

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Section: Resultsmentioning

confidence: 99%

Epidemiological survey and risk factors associated with hepatitis E virus in small ruminants in southern Spain

Caballero‐Gómez

García‐Bocanegra

Jiménez‐Martín

et al. 2022

Zoonoses and Public Health

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“…(2007) India / 2006 12.0 9/75 [4.6–19.3] 10.5 2/19 Diagnostic Automation (commercial kit for human) – – Junaid et al. (2014) Nigeria / 2012 31.8 56/176 ID-vet (commercial kit) – – Shuaibu et al. (2016) Nigeria / 2016 35.2 176/500 Commercial kit (Wantai) 5.3 4/75 Wu et al.…”

Section: Discussionmentioning

confidence: 99%

“…This was in accordance with prevalence from similar studies in Nigeria and China ( Geng et al., 2010a , Geng et al., 2010b , Junaid et al., 2014 ). Higher prevalence has been recorded with 29.0% to 35.2% in China ( Wu et al., 2010 , Wu et al., 2015 ), and 31.8% from Nigeria ( Shuaibu et al., 2016 ). The high prevalence recorded in China could be linked to the sheep breed studied, there specific strains and the geographic area.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of anti-hepatitis E virus antibodies in domestic animal from three representative provinces of Burkina Faso

Ouoba

Traoré

Rouamba³

et al. 2019

Veterinary and Animal Science

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Four major genotypes of Hepatitis E virus (HEV) have been documented worldwide (1–4) with genotypes 1 and 2 found in human in Sub-Saharan Africa. Human Hepatitis cases due to HEV genotype 3 and 4 are zoonotic with various animal identified as possible reservoirs. Recently, HEV genotype 3 was found in pigs and human beings in West Africa, which may change the epidemic in human. Here, we assessed the prevalence of HEV antibodies in various domestic and wild mammalians in Burkina Faso. Random sampling was performed between 2015 and 2017 to collect serum from 100 rabbits (Oryctolagus cuniculus) , 19 hares ( Lepus africana ), 72 cattle (Bos taurus) , 75 sheep (Ovis aries) and 81 goats (Capra aegagrus) in three provinces in Burkina Faso. A multi-species ELISA was performed on serum samples from 328 domestic animals and 19 hunting hares. HEV total antibodies were identified in 121 out of 347 specimens (34.9% CI95% [29.9–39.9]). Sera from rabbits (60% CI95% [50.4–69.6]), hares (52.6% CI95% [30.2–75.1]), cattle (26.4% CI95% [16.2–36.6]), sheep (12.0% CI95% [4.6–19.4]), and goats (28.4% CI95% [18.6–38.2]) tested positive for antibodies anti-HEV. In this study we evidence presence of HEV antibodies in various mammalians and highlight the importance of these species in the epidemiology of HEV infection in Burkina Faso.

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“…In Asia, China is characterized with a higher seroprevalence of up to 35.2% [52,70,72,85,86]; while levels of 12.7% in Jordan [74] and 5% in Turkey were recorded [73]. In Africa the following levels were recorded: 10.5-31.8% in Nigeria [79,87], 12.0% in Burkina Faso [76], and 4.4% in Egypt [75].…”

Section: Seroprevalence Of Hepatitis E Virus In Ruminantsmentioning

confidence: 99%

Hepatitis E Virus in Domestic Ruminants and Virus Excretion in Milk—A Potential Source of Zoonotic HEV Infection

Zahmanova,

Takova,

Lukov

et al. 2024

Viruses

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The hepatitis E virus is a serious health concern worldwide, with 20 million cases each year. Growing numbers of autochthonous HEV infections in industrialized nations are brought on via the zoonotic transmission of HEV genotypes 3 and 4. Pigs and wild boars are the main animal reservoirs of HEV and play the primary role in HEV transmission. Consumption of raw or undercooked pork meat and close contact with infected animals are the most common causes of hepatitis E infection in industrialized countries. However, during the past few years, mounting data describing HEV distribution has led experts to believe that additional animals, particularly domestic ruminant species (cow, goat, sheep, deer, buffalo, and yak), may also play a role in the spreading of HEV. Up to now, there have not been enough studies focused on HEV infections associated with animal milk and the impact that they could have on the epidemiology of HEV. This critical analysis discusses the role of domestic ruminants in zoonotic HEV transmissions. More specifically, we focus on concerns related to milk safety, the role of mixed farming in cross-species HEV infections, and what potential consequences these may have on public health.

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Prevalence of Hepatitis E Virus (HEV) Antibodies in Sheep from Sokoto State

Cited by 5 publications

References 0 publications

Epidemiological survey and risk factors associated with hepatitis E virus in small ruminants in southern Spain

Epidemiological survey and risk factors associated with hepatitis E virus in small ruminants in southern Spain

Prevalence of anti-hepatitis E virus antibodies in domestic animal from three representative provinces of Burkina Faso

Hepatitis E Virus in Domestic Ruminants and Virus Excretion in Milk—A Potential Source of Zoonotic HEV Infection

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