Prevalence of Hepatitis E Virus Antibodies Among Blood Donors: A Systematic Review and Meta-Analysis

Ferreira, Vinicíus Lins; Souza, Vanessa Rodrigues de; Muzzillo, Dominique Araújo; Pontarolo, Roberto

doi:10.5812/hepatmon.42875

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…The prevalence of HEV is marked in the developing countries more than developed countries due to the reduced sanitary conditions affecting water supply and frequent contamination of the food leading to the outbreaks [5,6]. Transfusion-transmitted hepatitis E virus (TT-HEV) has also been reported [7].…”

Section: Introductionmentioning

confidence: 99%

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Study of Hepatitis E Virus in Blood Donors

Al-Kasaby¹,

Zaki²

2019

TOMICROJ

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Introduction:Hepatitis E (HEV) is a major health problem affecting around one third of the world population. The prevalence of antibodies to HEV among blood donors have been documented in several countries in Europe and Asia. Objectives:The aims of the study are to estimate the seroprevalence of hepatitis E antibodies among healthy blood donors and to explore the factors associated with positive HEV antibodies among healthy blood donors. Moreover, to detect HEV viremia by real time polymerase chain reaction among seropositive blood donors for HEV. Methods:The study included 200 apparent healthy blood donors from Dakahlia Governorate, Egypt. Blood samples were collected from the blood donors for serological determination for specific hepatitis E virus immunoglobulin G (anti-HEV IgG) and specific hepatitis E virus immunoglobulin M (anti-HEV IgM). Positive samples for anti-HEV IgM were further subjected for determination of HEV-RNA by real time Polymerase Chain Reaction (PCR). Anti-HEV-IgG was positive in 50 donor (25%) anti-HEV-IgM was positive in 10 donors (5%) and HEV-RNA was positive in 6 donors (3%). Results and Discussion:The comparison between blood donors positive for anti-HEV-IgG and negative blood donors negative reveals significant association between anti-HEV-IgG and donors with older age (42.0 ± 9.7,P = 0.001),rural residence (76%, P = 0.001), workers in agricultural works (92%, P = 0.035) and elevated AST (31.28±14.28, P = 0.04). Regarding viral markers, there was significant prevalance between positive anti-HCV-IgG and positive anti-HEV-IgG (P = 0.003). Univariate analysis for risk factors associated with positive anti-HEV IgG reveals significant prevalence with older age (P = 0.001), rural residence (P < 0.001), positive anti-HCV-IgG (P = 0.004) and increase in AST (P = 0.045). However, on Multivariate analysis HEV infection was independently prevalent with older age (P < 0.001) and rural residence (P = 0.002). Conclusion:The present study highlights that HEV seroprevalence in blood donors is common finding. Further finding is the statistically significant correlation between antibodies to HCV and serological markers for HEV and even HEV viremia. Longitudinal studies may be needed to explore the clinical significance and cost effectiveness of screening of the blood donors for hepatitis E virus by serological tests and/or detection of viremia by Molecular testing.

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Section: Introductionmentioning

confidence: 99%

“…This high seroprevalence grasps the attention of the possibility of the transmission of HEV in the blood transfusion. The risk of transmission from a donor with asymptomatic viremia can be identified through the detection of HEV RNA by Nucleic Acid Test (NAT) [7].…”

Section: Introductionmentioning

confidence: 99%

Study of Hepatitis E Virus in Blood Donors

Al-Kasaby¹,

Zaki²

2019

TOMICROJ

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“…Both sero-prevalence and complications of HEV infected patients (up to 17% in high risk populations (16)(17)(18)) have forced greater susceptibility against this virus, especially in hygienic crisis of war. Infection of HEV is another major oral-fecal transmitted infection (19), which must be considered as another challenging problem of the region and worldwide (20,21).…”

Section: Action Plan For Controlmentioning

confidence: 99%

Epidemiology of Hepatitis A Virus Infections in Syria, 2017; War and Asylum Seekers: A Global Threat

Miri

Alavian²

2017

Iran Red Crescent Med J

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Breakdowns of the 7-year war in Syria, especially in the health care infrastructures, such as water networks, and in the basic health requirements, such as public hospitals, emergency equipment from one side and emigration of the skilled resources from the country from the other side, has led to a disaster not only for the residents and neighboring countries but also for all other countries, which accept asylum seekers. Deficiency of national immunization programs and safe water has increased the risk of new epidemics of enterally transmitted virus infections like Hepatitis A virus (HAV) infection. Ringing alarms of a public health emergency must concern all authorized policy makers around the world. Vaccination against HAV, both for residents and asylum seekers, controlling the immune system of all other nations involved in Syria, fixing the water networks, and investing on infrastructures of the primary hygiene requirements would eliminate the risk of communicable infections in all the region.

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Assessment of Hepatitis E virus transmission risks: a comprehensive review of cases among blood transfusion recipients and blood donors

Singson,

Shastry,

Sudheesh

et al. 2024

Infection Ecology & Epidemiology

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Background Hepatitis E Virus is a major cause of acute and fulminant hepatitis, particularly in developing countries. While the virus is commonly spread through the fecal-oral route, numerous cases of transfusion transmitted Hepatitis E Virus (TT-HEV) have been reported, raising concerns about its transmission via blood transfusions, especially in industrialized countries. The high prevalence of antibodies and viremia among asymptomatic blood donors further heightens the risk of transfusion-related transmission. However, there is still debate about the best strategy to minimize TT-HEV. Objective The review was conducted to Summarize the literature on TT-HEV infection cases and the prevalence of HEV among blood donors. Methods The databases PubMed, Scopus, Web of Science, Embase, and CINAHL were searched for relevant studies from 2000 to 2022. Serological and molecular screening data of HEV in blood donors were used to gather prevalence and incidence rates. TT-HEV cases were reviewed by examining evidence of HEV infection before and after transfusion. Results A total of 121 manuscripts reports the prevalence and incidence of HEV among blood donors and cases of TT-HEV. Twenty-six articles reported confirmed cases of TT-HEV and 101 articles reported on HEV prevalence or incidence among blood donors. Conclusion TT-HEV transmission through blood products is a real concern, especially for immunocompromised patients. The risk and severity of infection could vary between immunocompetent and immunosuppressed patients. To increase transfusion safety, the evaluation recommends HEV screening protocols, especially in endemic region.

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Prevalence of Hepatitis E Virus Antibodies Among Blood Donors: A Systematic Review and Meta-Analysis

Cited by 3 publications

References 38 publications

Study of Hepatitis E Virus in Blood Donors

Study of Hepatitis E Virus in Blood Donors

Epidemiology of Hepatitis A Virus Infections in Syria, 2017; War and Asylum Seekers: A Global Threat

Assessment of Hepatitis E virus transmission risks: a comprehensive review of cases among blood transfusion recipients and blood donors

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