Prevalence of hepatitis G virus and its strain variant, the GB agent, in blood donations and their transmission to recipients

Roth, W. Kurt; Waschk, Dorothee; Marx, Steven E.; Tschauder, Silvia; Zeuzem, S.; Bialleck, Heike; Weber, Heinrich C.; Seifried, Erhard

doi:10.1046/j.1537-2995.1997.37697335162.x

Cited by 66 publications

(63 citation statements)

References 14 publications

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“…Like hepatitis C virus, HGV can be transmitted by blood and blood products and appears to have a worldwide distribution [1, 2, 3, 4, 5, 6, 7]. Preliminary data suggest a 1–4% prevalence among blood donors in the US and Europe, up to 16% in patients with hepatitis B or C, and up to 24–50% in intravenous drug addicts [2, 4, 6, 8, 9, 10, 11, 12]. The clinical implications of HGV are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and Clinical Aspects of Hepatitis G Virus Infection in Blood Donors and Immunocompromised Recipients of HGV-Contaminated Blood

et al. 1998

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Background and objectives: The infectiousness and clinical relevance of the newly discovered blood-borne Flaviviridae-like agent, termed hepatitis G virus (HGV), are not well understood. Materials and methods: Twenty-three transfusion recipients of two HGV-affected long-term blood donors were studied for HGV genome and antibodies to the putative envelope 2 glycoprotein (anti-E2) of HGV. Nine recipients had nonhematological disorders and 14 suffered from severe hematological diseases and 7 of them received allogeneic bone marrow or blood stem cell transplantation. The molecular epidemiology of the observed HGV infection was studied by direct sequencing of parts of the 5′-noncoding region, NS3, and NS5 region of HGV in the 2 long-term donors and in their 6 recipients who became HGV RNA positive. Additionally, 549 individuals – homologous (n = 254) and autologous blood donors (n = 202), and medical staff (n = 89) – were investigated for the presence of HGV RNA. Results: HGV RNA in serum was found in 15 of the 23 (65%) transfusion recipients with known exposure of HGV-contaminated blood. Seven of the remaining 8 recipients showed only an anti-E2 response, indicating previous HGV infection with spontaneous clearance of the virus. In one recipient neither HGV RNA nor anti-E2 could be detected. Molecular evidence for HGV transmission by the 2 donors was found in 3 of the 6 recipients studied. The alanine aminotransferase levels were not significantly different in the HGV RNA positive and negative recipients, and none of the 23 recipients developed posttransfusion hepatitis. Persistent HGV infection was observed especially in recipients with severe hematological disorders or in those in whom intensive immunosuppressive treatment was necessary. Of the 549 individuals studied, 10 (1.8%) were healthy carriers of HGV RNA. Conclusion: The persistence of transfusion-acquired HGV infection is not associated with acute or chronic hepatitis, but may be influenced by the recipient’s underlying disease.

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Section: Introductionmentioning

confidence: 99%

Epidemiological and Clinical Aspects of Hepatitis G Virus Infection in Blood Donors and Immunocompromised Recipients of HGV-Contaminated Blood

et al. 1998

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“…GBV-C/HGV is transmitted through blood transfusion and blood components (Schmidt et al 1996, Roth et al 1997, Heuft et al 1998. Epidemiological data suggest that this virus is also spread by sexual and vertical transmission (Bourlet et al 1999, Stark et al 1999, Wejstål et al 1999.…”

mentioning

confidence: 99%

Prevalence and genotypes of GB Virus C/Hepatitis G virus among blood donors in Central Brazil

Oliveira

Martins

Carneiro

et al. 2002

Mem. Inst. Oswaldo Cruz

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“…Findings from European countries and Japan have also been in this range. For example, 1.3% of 1,048 German donors [7]and 1.2% of 1,302 Japanese donors [6]were found to be RNA positive. The Canadian results were lower than those seen in West Africa (14.2%) [8]and South Africa (11.1%) [9].…”

Section: Discussionmentioning

confidence: 99%

“…This virus is transmitted through transfusion of blood and blood components [1, 3, 4]and is presumed to be transmitted by other parenteral routes, such as injection drug use [5]. Of concern is the fact that multiple studies have found viremia to be relatively common in blood donors who give no history of parenteral exposures [6, 7, 8, 9]. For example, viremia, as defined by the presence of viral RNA in sera, has been found in 1.7% of nonremunerated US donors [1].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of GBV-C/Hepatitis G Virus Viremia and Anti-E2 in Canadian Blood Donors

Giulivi

Slinger

Tepper³

et al. 2000

Vox Sanguinis

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Background and Objectives: GB virus C (GBV-C)/hepatitis G virus (HGV) is a recently recognized parenterally and sexually transmitted agent. The prevalence of GBV-C/HGV markers in Canadian blood donors has not been previously studied and was therefore determined. Materials and Methods: Blood donors [identity unlinked (IU), short-term temporarily deferred (STTD) and autologous groups] and donor samples with antibodies to hepatitis C (anti-HCV) or hepatitis B core were tested for GBV-C/HGV RNA and for antibodies to E2 antigen (anti-E2). Results: GBV-C/HGV RNA was found in 1.1% and anti-E2 in 7.3% of the combined IU/STTD donor group. Viremia was much more common in anti-HCV-positive samples (12.5%); anti-E2 was present in >50% of this group. In the STTD group, female gender was significantly associated with viremia. Conclusion: GBV-C/HGV infection is relatively common in Canadian donors, and a small proportion are viremic. The association of female gender and viremia was unexpected. Further study is needed to clarify the epidemiology and natural history of GBV-C/HGV infection.

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Prevalence of hepatitis G virus and its strain variant, the GB agent, in blood donations and their transmission to recipients

Cited by 66 publications

References 14 publications

Epidemiological and Clinical Aspects of Hepatitis G Virus Infection in Blood Donors and Immunocompromised Recipients of HGV-Contaminated Blood

Epidemiological and Clinical Aspects of Hepatitis G Virus Infection in Blood Donors and Immunocompromised Recipients of HGV-Contaminated Blood

Prevalence and genotypes of GB Virus C/Hepatitis G virus among blood donors in Central Brazil

Prevalence of GBV-C/Hepatitis G Virus Viremia and Anti-E2 in Canadian Blood Donors

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