Prevalence of Heptavalent Vaccine- related Pneumococcal Serotypes in Nasopharyngeal carrier in children under five years old in Shahrekord, Iran by Multiplex-PCR during 2010- 2011

The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas. Two hundred twenty-one patients (116 males, median 67.9 years) with IPD were studied (pneumonia n = 103, meningitis n = 61 sepsis n = 50, other n = 7). Two hundred twelve were serotyped. The most frequent serotypes were 3, (31/212; 14.6%), 19A, (19/212; 9.0%), 12 (17/212; 8.0%), 7F, (14/212; 6.6%). In NP of children, the frequency of those serotypes causing over 50% of IPD in adults was very low, ranging from 0.48% for serotype 7F to 7.9% for serotype 19A. On the other side serotype 5, very frequent in NP (18.7%) caused <1% IPD. In conclusion serotypes causing IPD in adults are very rarely found in children NP. We suggest that herd protection obtainable with the additional 6 serotypes included in PCV13 may be more limited than that demonstrated with PCV7 in the past. In order to reduce the burden of disease in adults, adults should be offered a specific vaccination program with highly immunogenic PCV.

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“… 1-2,12-13 That situation is present today in countries were PCV7 vaccination has never been used. 14 …”

Section: Introductionmentioning

confidence: 99%

Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?

Azzari

Cortimiglia

Nieddu

et al. 2015

Human Vaccines & Immunotherapeutics

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“…According to the studies assessed, serotypes 19A, 23F, and 11 exhibited significantly higher levels of penicillin resistance (P < 0.05), whereas 19A, 1, 15A, 23F, 6A-B, 19F, 11, 35B showed higher rates oftetracycline resistance (P < 0.05) [14–17]. As it is shown, 19A, 23F, and 11 are amongst the most common serotypes having resistance to both penicillin and tetracycline.…”

Section: Resultsmentioning

confidence: 91%

“…According to the studies assessed in the current review, serotypes 19A, 23F exhibited significantly higher levels of penicillin resistance (P < 0.05) [14][15][16][17]. All these serotypes are PCV13 serotypes and this conjugate vaccine is probably able to offer protection against these drugresistant strains of S. pneumoniae in Iran.…”

Section: Discussionmentioning

confidence: 98%

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The status of Streptococcus pneumoniae in Iran compared to the world: a systematic review

Asadollahi

Darbandi

Lohrasbi

et al. 2021

Reviews and Research in Medical Microbiology

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Introduction:Streptococcus pneumoniae is a leading cause of vaccine-preventable deaths worldwide. Sero-epidemiological data on S. pneumoniae is needed in each country to monitor the burden of this important pathogen in each population. The aim of this study was to evaluate the prevalence, antibiotic resistance, prevalent serotypes and virulence factors of S. pneumoniae in Iran, compared to other parts of the world.Methods:A search via Google Scholar, Scopus, PubMed, ISI, Iranmedex, Magiran, SID and ISC was conducted for original articles investigating S. pneumoniae in Iran. The search terms were ‘Streptococcus pneumoniae’, ‘S. pneumoniae’, ‘prevalence’, ‘antibiotic resistance’, ‘antimicrobial resistance’, ‘typing’, ‘serotyping’, ‘virulence factors’, ‘Iran’.Results:The overall prevalence of invasive pneumococcal disease had an increasing trend in Iran. The most common serotypes amongst Iranian population were 1, 19A, 6A/ 6B, 23F, 14,18C, 20, 19, 3, 6, 9 V, 11A and 19F. Resistance to penicillin and co-trimoxazole had significant decreasing trends whilst resistance to erythromycin was increasing although insignificantly. The most prevalent pneumococcal virulence genes were lytA and pspC.Conclusion:Since pneumococcal serotypes differ in invasiveness, virulence, and antibiotic resistance it is important to closely monitor the changes on evolving serotypes, antibiotic resistance and virulence factors of this pathogen to be able to implement suitable prevention and therapeutic strategies.

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Pneumococcal serotype distribution: A snapshot of recent data in pediatric and adult populations around the world

Cui

Patel²,

O’Neil³

et al. 2017

Human Vaccines & Immunotherapeutics

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Prevalence of Heptavalent Vaccine- related Pneumococcal Serotypes in Nasopharyngeal carrier in children under five years old in Shahrekord, Iran by Multiplex-PCR during 2010- 2011

Cited by 4 publications

References 26 publications

Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?

Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?

The status of Streptococcus pneumoniae in Iran compared to the world: a systematic review

Pneumococcal serotype distribution: A snapshot of recent data in pediatric and adult populations around the world

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