Prevalence of Herpes Simplex Virus Infection in Patients With Relapsing-Remitting Multiple Sclerosis: A Case-Control Study in the North of Iran

Najafi, Saeideh; Ghane, Masood; Poortahmasebi, Vahdat; Jazayeri, Seyed Mohammad; Yousefzadeh-Chabok, Shahrokh

doi:10.5812/archcid.36576

Cited by 9 publications

(8 citation statements)

References 25 publications

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“…In a study conducted on the population of northern Iran, no significant difference was found in seropositivity for HSV antibodies in the MS patient and control groups. At the same time, the percentage of seropositive individuals was generally lower compared to that observed in our study [19]. It seems that there is an increased likelihood of HSV exposure in patients in north-eastern Poland.…”

Section: Discussioncontrasting

confidence: 49%

Herpesviridae Seropositivity in Patients with Multiple Sclerosis: First Polish Study

et al. 2018

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Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that leads to inflammation, demyelination and neurodegeneration. Viral aetiology has been suspected to be an MS trigger for a long time, and herpesviruses (HSs) are among the potential pathogens involved. Objectives: The present investigation aims to detect the presence of antibodies against the herpes simplex virus (HSV), varicella-zoster virus, Epstein-Barr virus (EBV), human cytomegalovirus (CMV) and human herpesvirus 6 (HHV6) in the serum of MS patients and control individuals in north-eastern Poland. Method: Plasma was collected from 141 MS patients and 44 blood donors who served as the control group. These individuals were assessed for the presence of antibodies using an enzyme-linked immunosorbent assay. Results: The statistical analysis showed a higher probability of EBV (p = 0.037, OR 4.359) and HHV6 (p = 0.020, OR 3.343) antibody presence in patients with MS compared to that in the control group. In the MS patient group, the prevalence of CMV IgG antibodies was significantly higher in females (p = 0.025). Patients who tested positive for anti-EBV IgG were diagnosed 7.9 years earlier than patients who tested negative for anti-EBV IgG (p = 0.048). Conclusions: The study showed that MS patients in north-eastern Poland were more likely to be seropositive for EBV and HHV6 than healthy individuals. Further work should be undertaken in other regions of Poland and other European countries with particular attention paid to testing seropositivity in all HSs, particularly in the MS patient population, to evaluate the impact of HSs on MS patients in different environments.

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Section: Discussioncontrasting

confidence: 49%

Herpesviridae Seropositivity in Patients with Multiple Sclerosis: First Polish Study

et al. 2018

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“…Omidian J 1 , Sheikhi-Shooshtari F 1* , Fazeli M 2 Introduction * erpes simplex virus types 1 (HSV-1) and 2 (HSV-2) belong to the same herpes virus family, Herpesviridae (1,2). Alphaherpesvirinae, a subfamily of Herpesviridae, is a common causative agent of human virus infection and includes herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV).…”

Section: Virus (Vzv) In Eye Infectionmentioning

confidence: 99%

“…Alphaherpesvirinae, a subfamily of Herpesviridae, is a common causative agent of human virus infection and includes herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). Although they are famous for resulting vesicles in the skin, the clinical manifestations which involve other areas than cutaneous area are more intrested (2,3). Herpes simplex virus (HSV) infections are very common worldwide.…”

Section: Virus (Vzv) In Eye Infectionmentioning

confidence: 99%

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Prevalence of Herpes Simplex Virus type-1, 2 and Varicella Zoster Virus (VZV) in Eye Infection

Omidian

Sheikhi-Shooshtari

Fazeli³

2015

Iran J Virol

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Background and Aims: Herpes simplex virus (HSV) is a common cause of corneal disease and is the leading infectious cause of corneal blindness among developed nations. This study is aimed to provide an estimation of the incidence of Herpes Simplex Virustype-1, 2(HSV1, 2) and Varicella Zoster Virus (VZV) in tears and swab from eye infection by polymerase chain reaction (PCR) in eye disease in a suspected community. Materials and Methods: Fifty subjects without signs of ocular herpetic disease enrolled in the study. Serum samples from all subjects were tested for HSV IgG antibodies by enzymelinked immunosorbent assay (ELISA). Subjects were instructed to collect tear samples by touching the inner surface of the lower eyelid with an individually wrapped, sterile cotton swab and to place the swab immediately into labeled sterile tubes. Swabs were kept at 4°C until processed. Nucleic acid was extracted from the samples and PCR-amplified for HSV DNA. Results: Among 50 samples, 3 samples were refused because internal controls were negative. HSV infection was established in 10% (5 out of 50) of all patients. The prevalence of HSV infection in patients with no clinical suspicion of herpetic keratitis was 6%. Histopathologic evaluation revealed that among samples with positive PCR results, 100% had evidence of inflammation, 55% had giant cells, 39% had necrosis, 59% had vascularization, 67 % had ulcer and 100% of them had inclusion bodies. Conclusions: Because some of the patients with no clinical suspicion of herpes infection were found positive, we suggest that HSV to be considered as one of the underlying etiologies in any patient with corneal scar and keratitis. Therefore, performing further diagnostic methods, including PCR and histopathology, is mandatory to clearly understand the infection.

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“…On a global basis, chronic infections of hepatitis B and C are responsible for nearly 60% of cases * Corresponding author: Maryam Fatemipour, E-mail: mfatemip@gmail.com of cirrhosis and almost 80% of cases of hepatocellular carcinoma [2]. The virus can remain in the host for a long period [3,4].…”

mentioning

confidence: 99%

Prevalence and epidemiology of hepatitis C virus (HCV) infection in Rafsanjan

Fatemipour¹,

Fatemipour

Vahedi

et al. 2016

Iran J Virol

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Background and Aims: Many individuals with chronic hepatitis C virus (HCV) infection are asymptomatic, population-based serologic studies are needed to estimate the prevalence of infection which will help to take necessary procedures for prevention and control the disease. This study was conducted to find out the prevalence, of HCV infection among patients referring to the hospital care in Rafsanjan, Iran. Materials and Methods: A total of 940 blood samples (430 males and 510 females) were received and screened for hepatitis C infection during December 2015 to December 2016. After separation of serum from blood samples in local laboratory, all samples were tested for HCV Ag by ELISA tests. Liver enzymes [Alkalin Phosphatase (ALP), Alanine aminotrans¬ferase (ALT) and Aspartate aminotransferase (AST)] were determined using biochemical procedures. Results: Amongst 940 collected samples, 18 (1.91%) were positive for HCV Antibody. Among the positive ones, HCV hepatitis was more prevalent in male patients than the females. The prevalence rate of HCV in male was 3.72% and 0.39% for female. Results related to age showed that higher rate of infection in 20-29 years old (%26.59), and the lowest was found in above 80 years old group (0.31%). Of the three enzymes, only ALP was significantly higher than the control group (P=0.003). Conclusions:The prevalence of HCV in Rafsanjan was at an increasing rate. Findings from the current study will be helpful for better management and control of viral hepatitis C infection.

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Prevalence of Herpes Simplex Virus Infection in Patients With Relapsing-Remitting Multiple Sclerosis: A Case-Control Study in the North of Iran

Cited by 9 publications

References 25 publications

Herpesviridae Seropositivity in Patients with Multiple Sclerosis: First Polish Study

Herpesviridae Seropositivity in Patients with Multiple Sclerosis: First Polish Study

Prevalence of Herpes Simplex Virus type-1, 2 and Varicella Zoster Virus (VZV) in Eye Infection

Prevalence and epidemiology of hepatitis C virus (HCV) infection in Rafsanjan

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