Background: Although human immunodeficiency virus (HIV) prevalence in the general population is very low in China, high infection rate has been reported among men who have sex with men (MSM). We conducted a meta-analysis to identify HIV infection associated risk factors among MSM in China, thus we can further understand the high-risk population and provided basic information to further develop specific and effective interventions of HIV prevention. Methods: A comprehensive literature search was conducted in several public databases, the relevant articles which published from January 2010 to June 2018 were identified, and a meta-analysis was performed according to these included studies. The odds ratio (OR) and its 95 % confidence intervals (CI) of each risk factor among MSM in China were pooled by using a random-effects model or fixed-effects model when appropriate. Results: A total of 23 articles were included and analyzed. The pooled results revealed that non-local residency (OR=2.31, 95% CI: 1.05, 5.08), education less than junior high school (OR=1.73, 95% CI: 1.36, 2.21), engaging in commercial sex (OR=2.99, 95% CI: 1.02, 8.72), preferred receptive sexual role (OR=2.43, 95% CI: 2.09, 2.83), having anal bleeding during anal intercourse (OR=2.22, 95% CI: 1.60, 3.07), having no HIV test in the last 12 months (OR=2.17, 95% CI: 1.45, 3.25), having unprotected anal intercourse (UAI) in the last 6 months (OR=2.06, 95% CI: 1.69, 2.50), recreational drugs use (OR=1.90, 95% CI: 1.53, 2.36), preferred versatile sexual role (OR=1.69, 95% CI: 1.35, 2.21), inadequate HIV related knowledge (OR=1.63, 95% CI: 1.26, 2.11), having multiple sexual partners (MSP) in the last 6 months (OR=1.35, 95% CI: 1.24, 2.47), having infection of syphilis (OR=3.22, 95% CI: 3.02, 3.44) and diagnosed with sexually transmitted infections (STI) in the last 12 months (OR=1.71, 95% CI: 1.30, 2.26) were significantly and positively related to HIV infection. Conclusions: Continuous education and further interventions such as Pre-Exposure Prophylaxis (PrEP) should be prioritized for those MSM who engaged in high-risk behaviors.