Prevalence of HIV-Associated Lipodystrophy in Brazil: A Systematic Review of the Literature

Justina, Lunara Basqueroto Della; Trevisol, Daisson José; Schuelter‐Trevisol, Fabiana

doi:10.4172/2155-6113.1000347

Cited by 2 publications

(4 citation statements)

References 33 publications

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“…The present study found a prevalence of 35.7% of lipodystrophy, and 21.2% of lipohypertrophy. These findings were consistent with those of a systematic review that found a prevalence of lipodystrophy ranging from 32.4 to 88.6% in PLWH, and a prevalence of lipohypertrophy between 12.1 and 49.2% (19) . In all the anthropometric parameters evaluated (BMI, %F, WC, WHR, and WTHR) the participants presented excess body weight or abdominal fat, which are risk factors for cardiovascular diseases.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, the prevalence of overweight and obesity was shown to be higher among women than among men, in both the general population and among HIV-infected people (25)(26)(27)(28) . Several studies corroborate the findings that women have higher prevalence of central lipohypertrophy or mixed lipodystrophy syndrome compared to men, whereas men have a higher prevalence of peripheral lipoatrophy than women, although at higher risk for visceral fat (13,19,22,27) .…”

Section: Discussionsupporting

confidence: 63%

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Lipohypertrophy and nutritional profile among people living with HIV in Southern Brazil

Schuelter-Trevisol

Silva

et al. 2022

J Bras Doenças Sex Transm

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Introduction: People living with the human immunodeficiency virus (HIV) are generally overweight or have an altered body composition as compared to healthy individuals, showing a change in nutritional profile over time. Objective: The aim of the study was to characterize the nutritional status, estimate the prevalence of lipodystrophy, and examine the association between lipohypertrophy and lipid profile alterations, and other clinical data of HIV-infected individuals. Methods: This was a cross-sectional study on male and female subjects living with HIV, treated at a specialized outpatient clinic, aged 18 years old and over, whether using the antiretroviral therapy or not. Results: The sample consisted of 420 people with a mean age of 43.8 years (standard deviation 11.7). The length of time of the HIV infection averaged 74.6 months, and 91% of the respondents were on antiretroviral therapy. Lipodystrophy prevalence was 35.7%. Of these, 82 (54.7%) presented lipohypertrophy, 61 (40.7%) had lipoatrophy and 7 (4.6%) had a mixed syndrome. Female gender, body mass index, fat percentage, waist circumference and waist-hip ratio were positively associated with the presence of lipohypertrophy (p<0.001). High mean total cholesterol (p=0.015) and LDL fraction (p=0.028) also showed a statistically significant association with lipohypertrophy. The sampled participants had a nutritional profile compatible with overweight or obesity. No association was found between lipohypertrophy and ART and the therapy duration. Conclusion: Considering the consequences of overweight as a cause of various pathological conditions, preventive measures and interventions are highly recommended for this population.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 63%

Lipohypertrophy and nutritional profile among people living with HIV in Southern Brazil

Schuelter-Trevisol

Silva

et al. 2022

J Bras Doenças Sex Transm

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“…The level of physical activity was not associated with lipodystrophy in the present study. How-ever, the literature reports a high incidence of sedentarism among individuals with HIV-associated lipodystrophy 30,34,42 , indicating that the practice of physical activity may be a protection factor regarding the occurrence of this syndrome 43 . The practice of physical activity combined with an adequate diet is known to reduce the progression of lipodystrophy and lower its impact on both health and quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, Silva 50 evaluated 219 patients who were not in regular use of antiretrovirals and found an association between a lower CD4+ count and higher BMI as well as higher percentage of body fat. These findings may be the result of the harmful effects of HIV infection itself, probably as a consequence of the activation of macrophages in adipose cells, which could increase both local and systemic inflammation 30,51 .…”

Section: Discussionmentioning

confidence: 99%

Síndrome lipodistrófica do HIV e seus fatores associados: um estudo em um hospital universitário

Silva

Santos

Nascimento

et al. 2020

Ciênc. saúde coletiva

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The use of antiretroviral drugs has increased the survival of HIV patients, but may have side effects, such as lipodystrophic syndrome. This article aims to identify the frequency of the lipodystrophic syndrome and its associated factors in patients with HIV using antiretroviral therapy. It involved a cross-sectional study with HIV patients, monitored on an outpatient basis. The syndrome was evaluated by the association of two parameters: peripheral weight loss through the lipodystrophy severity scale and central fat accumulation, measured by the hip waist ratio. Poisson regression analysis was performed to identify the associated variables. Of the 104 patients evaluated, 27.9% presented the syndrome. After adjustment, the female sex (PR adjusted = 2.16 CI 95% 1. 43-3.39), being overweight (PR adjusted = 2.23 CI 95% 1. 35-2.65) and a longer period of use of antiretrovirals (PR adjusted = 1.64 CI 95% 1.16-2.78), remained positively associated with the syndrome. On the other hand, a negative association with CD4 count £ 350 (PR adjusted = 0.39 CI 95% 0.10-0.97) was observed The high prevalence of the syndrome and its association with specific groups reinforce the need for adequate follow-up and early identification to intervene in modifiable factors.

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Prevalence of HIV-Associated Lipodystrophy in Brazil: A Systematic Review of the Literature

Cited by 2 publications

References 33 publications

Lipohypertrophy and nutritional profile among people living with HIV in Southern Brazil

Lipohypertrophy and nutritional profile among people living with HIV in Southern Brazil

Síndrome lipodistrófica do HIV e seus fatores associados: um estudo em um hospital universitário

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