Prevalence of HIV in Blood Donors

Tiwari, Bishnu Raj; Karki, Surendra; Ghimire, Prakash; Yadav, Pooja; Rajkarnikar, Manita

doi:10.3126/jnhrc.v6i2.2203

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…In this study, the overall prevalence of HIV infection was 476 (5.1%) but showed a decreasing trend from 2008 to 2012. A decreasing trend in HIV seroprevalence among blood donors was reported from Kathmandu, Nepal 14 and West African country, Mali. 15 …”

Section: Discussionmentioning

confidence: 94%

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HIV-Sero- prevalence trend among blood donors in North East Ethiopia

et al. 2017

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BackgroundAlthough blood transfusion is one of the known therapeutic interventions that cuts across a number of clinical disciplines. It is necessary to test all intending blood donors for HIV infection before donation. The aim of this study was to determine the prevalence of HIV among blood donors at Dessie Blood Bank, Northeast Ethiopia.MethodsA retrospective study was conducted in Dessie Blood Bank through the year 2008–2012. Sera from blood donors were tested for the detection of Anti HIV by using 4th generation ELISA. Data were abstracted from records and analyzed using Microsoft Excel sheet.ResultsFrom the total of 9384 screened blood samples collected, the prevalence of HIV in blood donors in the blood bank was 5.1% in the five consecutive years but the trend of HIV infection has decreased from 2008(5.2%) to 2012 (2.3%). The age groups 15–24 and 35–44 were the highest prevalence and the age group 45–54 was the lowest prevalence of HIV infection. The prevalence of HIV among female (7.9%) was higher than in male donors (4.4%). The trend of HIV infection was decreasing for both male and female blood donors.ConclusionThe prevalence of HIV infections among blood donors is still high in this study setting, and needs constant monitoring to evaluate prevention and control strategies to reduce the burden of transfusion-transmissible HIV infections.

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Section: Discussionmentioning

confidence: 94%

“…13 The overall seroprevalence of HIV among the total blood donors in nation wide and in Central Blood Transfusion Service (CBTS), Kathmandu, Nepal through the six years of review (from 2001–2007) was 0.33% and 0.4% respectively. 14 …”

Section: Introductionmentioning

confidence: 99%

HIV-Sero- prevalence trend among blood donors in North East Ethiopia

et al. 2017

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“…Zimbabwe, like most developing countries, has generalized HIV epidemic and the relationship between general and donor population HIV needs proper monitoring and evaluation as this impacts the blood safety strategies. It is generally accepted that the HIV prevalence in blood donors if cautiously interpreted can provide useful insight to the epidemic condition in the general population and vice versa . We are currently conducting such studies in Zimbabwe, which have been undertaken in other settings…”

Section: Discussionmentioning

confidence: 99%

“…It is generally accepted that the HIV prevalence in blood donors if cautiously interpreted can provide useful insight to the epidemic condition in the general population and vice versa. 29 We are currently conducting such studies in Zimbabwe, which have been undertaken in other settings. 30,31 NBSZ through its strengthened blood safety program is aware of its potential contribution to the continued fight against HIV and AIDS in Zimbabwe.…”

Section: Discussionmentioning

confidence: 99%

Human immunodeficiency virus prevalence, incidence, and residual transmission risk in first‐time and repeat blood donations in Zimbabwe: implications on blood safety

et al. 2013

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The significantly high HIV prevalence estimates recorded in first-time over repeat donations is indicative of the effectiveness of the HIV risk management strategy. However, comparable residual transmission risk estimates in first-time and repeat donors point to the need to further review the risk management strategies. Given the potential wastage of valuable resources, future studies should focus on the cost-effectiveness and utility of screening and discarding first-time donations.

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“…This was greater than detected prevalence (0.5%) in 2009 in the country by UNAIDS [27], 0.56% for South and South-East Asia in 2001 [28], and the also mentioned 0.2-0.5% for India in 2008 by UNAIDS/WHO [29]. This finding was also higher than blood donors reported 0.33% in 2008 by Tiwari et al [30], 0.222% in 1993 among normal Nepalese people by Shrestha et al [31], and 0.30% in 2012 among adult aged 15-49 years group by MOHP/NCASC [32]. This detection of higher distribution may be due to being a major referral and tertiary care centre of the country.…”

Section: Discussionmentioning

confidence: 67%

Human Immuno-Deficiency Virus Co-Infection with Hepatitis B Virus and Baseline CD4+ T Cell Count among Patients Attending a Tertiary Care Hospital, Nepal

Baral¹,

Sherchand²,

Parajuli³

et al. 2017

J Med - Clin Res & Rev

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Background: Since 1981, when the first AIDS case was reported, worldwide, more than 34 million people have been infected with HIV. Almost 95 percent of the people infected with HIV live in developing countries. As HBV & HIV share similar routes of transmission by sexual intercourse or drug use by parenteral injection, co-infection is common. Because of the limited access to healthcare & HIV treatment in developing countries, HIV-infected individuals are present late for care. Enumeration of CD4+ T cell count at the time of diagnosis has been useful to initiate the therapy in HIV infected individuals. The baseline CD4+ T cell count shows high immunological variability among patients.Methods: This prospective study was done in the serology section of the Department of Microbiology over a period of one year from august 2012 to July 2013. A total of 13037 individuals subjected for HIV test were included in the study comprising of 4982 males & 8055 females. Blood sample was collected by vein puncture aseptically with standard operational procedure in clean & dry test-tube. All blood samples were screened for HIV as described by WHO algorithm by Immuno-chromatography rapid kits. Further confirmation was done by biokit ELISA method as per the manufacturer's guidelines. After informed consent, HIV positive individuals were screened for HBsAg by Immuno-chromatography rapid kits (Hepacard). Further confirmation was done by biokit ELISA method as per the manufacturer's guidelines. EDTA blood samples were collected from the HIV sero-positive individuals for baseline CD4+ T count. Then, CD4+ T cells count was determined by using FACS Calibur Flow Cytometer (BD).Results: Among 13037 individuals screened for HIV, 104 (0.8%) were found to be infected comprising of 69(66.34%) males & 35 (33.65%) females. The study showed that the high infection was noted in active age group (30.76%), housewives (28.7%) & in heterosexual route (80.9%) of transmission. Out of total HIV infected individuals, distribution of HBV co-infection was found to be 6 (5.7%). Baseline CD4+ T cell count of HIV infected patient was found higher (mean CD4+ T cell count; 283cells/cu.mm) than HBV coinfected patients (mean CD4+ T cell count; 91 cells/cu.mm). Majority (77.2%) of HIV infected & all co-infected individuals were presented in our center late (CD4+ T cell count;< 350/cu. mm) for diagnosis and care. Majority of co-infected 4 (80%) were late presented with advanced AIDS stage (CD4+ count; <200/cu.mm). Conclusions:The study showed a high percentage of HIV sero-positive & co-infected individuals. Baseline CD4+ T cell count of majority of HIV infected individuals was found to be low. Hence, more sustained and vigorous awareness campaigns & counseling still need to be done in order to promote early diagnosis and management.

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Prevalence of HIV in Blood Donors

Cited by 4 publications

References 6 publications

HIV-Sero- prevalence trend among blood donors in North East Ethiopia

HIV-Sero- prevalence trend among blood donors in North East Ethiopia

Human immunodeficiency virus prevalence, incidence, and residual transmission risk in first‐time and repeat blood donations in Zimbabwe: implications on blood safety

Human Immuno-Deficiency Virus Co-Infection with Hepatitis B Virus and Baseline CD4+ T Cell Count among Patients Attending a Tertiary Care Hospital, Nepal

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