Prevalence of Human Papilloma Virus Infections and Cervical Cytological Abnormalities among Korean Women with Systemic Lupus Erythematosus

Lee, You Hyun; Choe, Jung Yoon; Park, Sunghoon; Park, Yong Wook; Lee, Shin Seok; Kang, Young Mo; Nam, Eon Jeong; Park, Won; Kwon, Seong Ryul; Bae, Sang Cheol; Kim, Yun Jung; Suh, Chang‐Hee; Kim, Hyoun‐Ah; Hur, Nam Wook; Lee, Sang Hoon

doi:10.3346/jkms.2010.25.10.1431

Cited by 43 publications

(36 citation statements)

References 28 publications

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“…This come in agreement with Lee et al that found high prevalence of HPV infection (24.6%) among Korean patients with SLE in comparison with 7.9% (p > 0.001) in healthy women (22) . In addition, Tam et al found in SLE patient high prevalence of HPV infection and abnormal pap smears (25%) which statistically increased to 48.5% after 3 years follow up with persistent and multiple HPV infections when compared non-SLE patients with cervical dysplasia (23) .…”

Section: Discussion:-supporting

confidence: 82%

Abnormal Pap Tests in Systemic Lupus Erythematosis: A Cytopathological and Human Papillomavirus Testing Study.

Girbash¹,

Atta²,

Fahmy³

et al. 2016

IJAR

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Objectives: the frequency of cervical squamous intra-epithelial lesions (SIL) in women with systemic lupus erythematosus (SLE), and the association between clinical parameters, use of immunosuppressant agents, human papillomavirus (HPV) infection, colposcopy, and development of SIL in SLE.Methods: A retrospective case control study conducted in 150 women constituted the study group with confirmed diagnosis of SLE. The enrolled patients divided into study group (no.28) with abnormal pap smears and reference group (no.122) with normal pap smears. All patients subjected to clinical evaluation, colposcopy, directed biopsies, and HPV-ISH testing. All participants reassessed every 6 months for 2 years.Results: mean patient age with abnormal pap smears was 44.8(P = 0.74) years with mean SLE disease duration was 9.3±7.1 years. There was past history of cervical lesions where it was positive in 89.3% (P = 0.001). SLE patients with abnormal pap smears showed significant difference regarding nephritis (P = 0.001) and high titers of Anti-double stranded DNA (P = 0.001) and Antiphospholipid antibodies (P = 0.012). SLEDAI, SDI, and immunosuppressant agent usage found significantly different among patients with abnormal pap smears. HPV Infection found significantly important (P = 0.001) when the infection was high-risk HPV, multiple HPV, or persistent HPV infection among patients with abnormal pap smears. On comparison with cytology, colposcopy, HPV-ISH results, the best sensitivity was with the use of HPV-ISH (90%) then with colposcopy (75%). In addition, the best specificity was with the use of colposcopy (99%). The highest positive predictive value was with colposcopy (94%) and the highest negative predictive value was with HPV-ISH assay (98%). Conclusion:Patients with SLE had higher risk for HPV infection and cervical dysplasia than the general population. Thus, gynecological visits at shorter intervals (3-6 months) recommended for those patients. The use of colposcopy is useful tool in areas where the screening of HPV is not available.

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Section: Discussion:-supporting

confidence: 82%

Abnormal Pap Tests in Systemic Lupus Erythematosis: A Cytopathological and Human Papillomavirus Testing Study.

Girbash¹,

Atta²,

Fahmy³

et al. 2016

IJAR

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show abstract

“…It has been shown that human papillomavirus (HPV) infection occurs more often in patients with SLE, also with the high-risk (oncogenic) subtypes of the virus 103–105. A lower percentage of these infections (31.8%) is spontaneously cleared by patients with SLE,106 leading to an increased risk of developing cervical cancer.…”

Section: Resultsmentioning

confidence: 99%

EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases

et al. 2010

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Evidence was graded in categories I-IV, the strength of recommendations was graded in categories A-D and Delphi voting was applied to determine the level of agreement between the experts of the task force. Results Eight key questions and 13 recommendations addressing vaccination in patients with AIIRD were formulated. The strength of each recommendation was determined. Delphi voting revealed a very high level of agreement with the recommendations among the experts of the task force. Finally, a research agenda was proposed. Conclusion Recommendations for vaccination in patients with AIIRD based on the currently available evidence and expert opinion were formulated. More research is needed, particularly regarding the incidence of vaccine-preventable infectious diseases and the safety of vaccination in patients with AIIRD.

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“…[49][50][51] The cumulative prevalence rises from 12.5% at study entry (11.1% high-risk subtype) to 25.0% (20.8% high-risk sub type) after 3 years. Only 14.7% of all incident infections are cleared in this time frame.…”

Section: Human Papillomavirusmentioning

confidence: 98%

“…52 general population as well as the presence of anti-nuclear antibodies (ANAs) at a titration >1:320. 49,51,52 Efficacy of vaccination At least some vaccine-preventable infections are more common in patients with an AIRD than in the general population; therefore, efficacy of vaccination in these patients should be addressed. The aim of vaccination is to reduce morbidity and mortality that is directly or indirectly provoked by infection.…”

Section: Human Papillomavirusmentioning

confidence: 99%

Vaccination of patients with autoimmune inflammatory rheumatic diseases

et al. 2014

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Patients with autoimmune inflammatory rheumatic diseases (AIRDs) are at increased risk of infections. This risk has been further increased by the introduction of biologic agents over the past two decades. One of the most effective strategies to prevent infection is vaccination. However, patients with an AIRD have a compromised immune system, which is further impaired by medication. Another important issue is the possibility of triggering a broad nonspecific response by vaccination, potentially resulting in increased activity of the underlying autoimmune disease. In this Review, we provide an analysis of data on vaccination of patients with an AIRD. Both the efficacy and the safety of vaccination are addressed, together with the epidemiology of vaccine-preventable infectious diseases in different subgroups of adults with AIRDs. Special attention is given to vaccination of patients who are treated with biologic agents.

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Prevalence of Human Papilloma Virus Infections and Cervical Cytological Abnormalities among Korean Women with Systemic Lupus Erythematosus

Cited by 43 publications

References 28 publications

Abnormal Pap Tests in Systemic Lupus Erythematosis: A Cytopathological and Human Papillomavirus Testing Study.

Abnormal Pap Tests in Systemic Lupus Erythematosis: A Cytopathological and Human Papillomavirus Testing Study.

EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases

Vaccination of patients with autoimmune inflammatory rheumatic diseases

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