Prevalence of human papillomavirus and subtype distribution in male partners of women with cervical intraepithelial neoplasia (CIN): a systematic review

Abstract

Background Human Papillomavirus (HPV) infection is estimated to be the most common sexually transmitted infection. The present systematic review summarizes data regarding the prevalence of HPV and the distribution of subtypes in heterosexual male partners of women, who were diagnosed with any grade of cervical intraepithelial neoplasia (CIN). Methods We conducted a systematic review of the literature by Medline and Google Scholar databases using the terms “Human Papillomavirus” or “HPV” plus “men” or “male partners” or “women with CIN”. We included original published English-language articles published from 1/1/2000 until 1/1/2018 that had screened male partners of women with CIN using HPV DNA testing. We excluded studies that they overlapped with other included studies or were unrelated to the study subject. Results We included a total of 12 publications, which reported the prevalence of HPV in free-clinical signs male partners of women with CIN. The largest proportion of the studies were from South America (seven studies), and the rest from Europe. The mean age of participants was 35.18 + − 3.47 years. HPV prevalence ranged from 12.9 to 86%; the total HPV prevalence among the studies was 49.1%, while ten out twelve studies (83.3%) demonstrated prevalence > 20%. Between the studies, the distribution of HPV subtypes varied on the basis of the method used, on the population and on the geographic region. A great variety of subtypes were detected, including 6, 11, 16, 18, 31, 33, 40, 42, 45, 51, 52, 53, 54, 56, 57, 58, 59, 61, 62, 66, 68, 81 and 83. In six studies the HPV 16 was the most frequent, while in two others the HPV 6 and HPV 83. Conclusions Until now, there are not precise screening or surveillance guidelines for the management of partners of women with CIN. This population is frequently colonized by various HPV subtypes and therefore need to be screened in an effort to reduce the infection in both sexes. The screening test could include detection/identification of HPV subtypes by a molecular assay, followed by peniscopy only in the positive cases.

Studi Awal Analisis Molekuler Human Papillomavirus dari Apusan Glans dan Batang Penis

“…4 Prevalensi HPV lebih tinggi pada pria yang merupakan pasangan wanita dengan cervical intraepithelial neoplasia, yaitu sebesar 49.1%, berkisar antara 12.9% hingga 86%. 5 Studi pada pasangan Iran yang dirujuk untuk pemeriksaan HPV, 16.3% pasangan memiliki kesamaan HPV positif. 6 Studi pada 50 orang pria pasangan seksual wanita dengan infeksi HPV genital, 76% ditemukan positif DNA HPV.…”

Preventing Human Papilloma Virus through Community Education and Vaccination

“…Frequently, HPV lives on the skin in the form of warts, however these growths can appear inside the organs described. Prevention of spread of anogenital warts is critical to decreasing the progression of cancer in males and females alike [16].…”

The role of human papillomavirus in the pathogenesis of sinonasal inverted papilloma: a narrative review

“…16 These HPVs are stratified into low risk (e.g., HPV-6, -11, -42, -44, -54, -61), thought to generally cause benign lesions such as condylomata; and high risk (e.g., HPV-16, -18, -31, -33, -45, -52, -58) causing precancerous and cancerous mucosal lesions. 17,18 The direct causality of cervical cancer from α-HPV infection is well known based on the consistent presence of viral DNA in lesions. 19 Similarly, high risk HPVs, most commonly HPV-16, are known to cause oropharyngeal carcinomas arising from the epithelium of lingual and palatine mucosa.…”