Prevalence of human papillomavirus genotypes, and mucosal IgA anti-viral responses in women with cervical ectopy

Monroy, Olga L.; Aguilar, Cecilia; Lizano, Marcela; Cruz-Talonia, Fernando; Cruz, Rosa M.; Rocha‐Zavaleta, Leticia

doi:10.1016/j.jcv.2009.10.008

Cited by 17 publications

(27 citation statements)

References 40 publications

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“…HPV 18, which was the second most common detected type after HPV 16 in regions of eastern Asia, northern Africa, and northern and western Europe [de Sanjosé et al, 2007], was the most commonly seen type in this study. This observation agrees with a previous report, in which the presence of HPV18 was found more than HPV16 in the endocervix of normal women, supporting the idea that columnar epithelium is preferentially infected by HPV18 [Monroy et al, 2010].…”

Section: Discussionsupporting

confidence: 93%

“…Rocha-Zavaleta et al [2004] and Monroy et al [2010] found that the prevalence of HPV in cervical ectopy was significantly higher than that observed in control tissue. There was a strong positive trend of increasing carcinogenic HPV positivity with greater degrees of cervical ectopy [Castle et al, 2006].…”

Section: Discussionmentioning

confidence: 98%

“…Zhang et al [2010] reported that the incidence of cervical erosion was higher in HPV-positive women than in HPV-negative women. The HPV infection rates were reported 30.8% [Xue et al, 2005], 31.8% [Li et al, 1999], 73.7% [Monroy et al, 2010], and 77.3% [Cui et al, 1994] in women with cervical erosion. The finding of this study is in accordance with earlier studies showing that HPV prevalence is increased in patients with cervical erosion.…”

Section: Discussionmentioning

confidence: 99%

“…When the area of epithelial defect is exposed to purulent secretions and irritants which are common in sexual transmitted disease, continuation of pathological process is observed [Chaudhuri et al, 1998]. Although most women are asymptomatic, the condition can be a potential risk factor for various sexually transmitted diseases, including HPV infection [Monroy et al, 2010]. A further aim of this study was to establish the association between HPV infection and the results of cervical cytology in women with and without cervical erosion.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and genotype distribution of human papillomavirus in non‐neoplastic cervical tissue lesion: Cervical erosion

Bayram

Erkılıç

Balat

et al. 2011

Journal of Medical Virology

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Human papillomavirus (HPV) infection is the commonest sexually transmitted infection, which is associated with various clinical conditions, ranging from asymptomatic infection to malignant disease of the cervix. The aim of this study was to evaluate the prevalence and genotypic distribution of HPV in women with cervical erosion and to compare the results with those in women with a clinically normal cervix. A further aim was to establish the association between HPV infection and cervical cytology results in women with and without cervical erosion. Cervical samples were collected by liquid-based method and consecutively evaluated for the presence of HPV DNA and for cervical cytology. HPV DNA was tested by a nested polymerase chain reaction (PCR) and typed by reverse dot blot genotyping. Cytological classification was made according to Bethesda 2001 criteria. The overall HPV prevalence was 16.9%; HPV DNA was positive in 20.2% of women with cervical erosion and 12.8% in women with normal cervix (P < 0.05). Multiple infections were found in 34.1% of the HPV-positive women. Commonest types were HPV 18 (32.9%), HPV 16 (29.5%), HPV 54 (20.5%), and HPV 6 (17%). Cervical cytology results were abnormal for 5.2% of women with cervical erosion and for 1.3% with clinically normal cervix (P < 0.05). This study detected a high prevalence of HPV infection in women with cervical erosion compared to women with a normal cervix. This data may contribute to the HPV epidemiology in the southeastern Turkey. It is recommended that women with cervical erosion should be given priority in HPV screening programs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and genotype distribution of human papillomavirus in non‐neoplastic cervical tissue lesion: Cervical erosion

Bayram

Erkılıç

Balat

et al. 2011

Journal of Medical Virology

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“…In addition, in several cross-sectional studies, in particular among older women, a significant correlation between the presence of CE and the prevalence of HPV infection was found, in particular type 16 [12,13] and even more frequent -type 18 [14], presence of which is known to be associated with the cervical adenocarcinoma. A number of recent studies have also found that vaginal biocenosis disturbances play an important role in the development of cervical squamous intraepithelial lesions [15,16].…”

Section: Introductionmentioning

confidence: 95%

Analysis of Complicated Cervical Ectopy Clinical Course and Recurrence

Mazur

Pyrohova

2018

EUREKA: Health Sciences

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Physiological cervical ectopy (CE) is commonly found in young women, during pregnancy or intake of oral contraceptives. The complicated (pathological) CE, particularly in conditions of vaginal microbiota disturbances and human papillomavirus (HPV) infection, requires intervention, including optimal treatment and effective relapse prevention approaches. Aim. The aim of the research was to investigate the complicated CE clinical course and recurrence features on the basis of a retrospective analysis of archival medical records in order to optimize the tactics of the complicated CE management and the relapse prevention measures. Materials and methods. In the observational cross-sectional retrospective study using the continuous sampling method were included 740 case reports of women, who underwent inpatient treatment of gynecological pathology in Lviv Municipal Clinical First Aid Hospital in 2006–2017. The inclusion criterion was the presence of firstly diagnosed or recurrent CE. Exclusion criteria: absence of CE colposcopic or morphological confirmation, presence of physiological CE (on conditions of cytological, bacterioscopical, bacteriological and colposcopical abnormalities absence). Subsequently, three groups were formed: control group (n=150) – healthy women, who applied for a regular gynecological examination; group 1 (n=483) – women with firstly diagnosed CE; group 2 (n=257) – women with recurrent CE. Differences in mean values were considered significant with a probability level of at least 95 % (p<0.05). Results. Patients with recurrent CE had more pregnancies (p<0.05) than the ones with firstly diagnosed CE and women of control group. The proportion of women with high parity in group 1 and group 2 was three times higher (p<0.05), than in group 3. The proportion of artificial abortions in patients of groups 1 and 2 was more than two times higher (p<0.05), than in women in the control group, group 2 patients had more miscarriages and missed miscarriages(p<0.05) in comparison to the control group. Menarche in patients with recurrent CE set in later in comparison to women of control group (p<0.05). In group 2, the proportion of women with polymenorrhea was three times higher (p<0.05), than in group 1 and control group respectively. The compromised gynecological history was more often (p<0.05) detected in group 1 and group 2, than in the control group. In patients with recurrent CE a third of gynecologic diseases in the history (32.30±2.92 %) and 23.60±1.93 % - in patients with the firstly diagnosed CE were pelvic inflammatory diseases, significantly (p<0.05) higher in comparison to the control group (3.33±1.47 %). Almost half of patients in group 1 (48.25±2.27 %) and group 2 (47.84±3.13 %) had the history of frequent infectious diseases, this indicator was significantly (p<0.05) higher in comparison to the control group (24.67±3.52 %). In patients with recurrent CE chronic diseases of different etiology were diagnosed more often (p<0.05) - their share made up 8.24±1.72 %, while in patients with firstly diagnosed CE - 4.33±0.92 %, in women of the control group - 1.33±0.94 %.The firstly diagnosed CE was more frequent (in comparison to recurrent CE) (p<0.001) characterized by asymptomatic course, whereas about half of patients with recurrent CE (46.69±3.11 %) presented with different complaints. Cytological indicators of cervicitis were found more often in patients with firstly diagnosed and recurrent CE, than in women of control group, as well as vaginal candidosis (p<0.05). Patients with recurrent CE more often (p<0.05) underwent diathermoconization (24.12±2.67 %) and cryodestruction of the cervix (8.17±1.71 %) in comparison to patients of group 1. The most often performed treatment method in patients of both groups was diathermoconization. Treatment methods aimed to restore the hormonal balance, to normalize the state of vaginal microbiota were rarely found in both group 1 and 2, drugs that affect the reparation and regeneration of the epithelium have not been used in any case. Conclusions. Recurrent symptomatic complicated CE should be interpreted as a complex problem that requires a multi-polar approach aimed at hormonal homeostasis, local immunity, and vaginal biocenosis normalizing. These measures should precede invasive treatment and further create optimal conditions for regeneration of the cervix.

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Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil

Coser

Boeira

Wolf

et al. 2016

The Brazilian Journal of Infectious Diseases

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Human papillomavirus (HPV) infection is common in sexually active women and viral persistence may cause intraepithelial lesions and eventually progress to cervical cancer (CC). The present study aimed to investigate epidemiological factors related to HPV infection and to evaluate viral persistence and CC precursor lesions frequencies in women from a city in the countryside of South Brazil. Three hundred women were recruited from a primary public health care clinic. The patients were interviewed and underwent sampling with cervical brushes for HPV-DNA detection/typing by a PCR-based assay and cytological analysis by Pap smear test. HPV was detected in 47 (15.7%) women. HPV infection was significantly associated with young age (<30 years) and low socio-economic status. Seventeen (5.7%) women presented cytological abnormalities, three of them with precursor CC intraepithelial lesions. A subgroup of 79 women had been previously analyzed and thirteen (16.4%) were persistently infected, two with precursor CC intraepithelial lesions and high-risk HPV types infection (both of them without cervical abnormalities in the first exam). In conclusion, HPV infection was associated with young age (<30 years) and low family income; viral persistence was low (16.4%) but related to CC precursor lesions; and HPV-DNA high risk types detection would help to screen CC in the population.

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Prevalence of human papillomavirus genotypes, and mucosal IgA anti-viral responses in women with cervical ectopy

Cited by 17 publications

References 40 publications

Prevalence and genotype distribution of human papillomavirus in non‐neoplastic cervical tissue lesion: Cervical erosion

Prevalence and genotype distribution of human papillomavirus in non‐neoplastic cervical tissue lesion: Cervical erosion

Analysis of Complicated Cervical Ectopy Clinical Course and Recurrence

Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil

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