Prevalence  of Human Papillomavirus (HPV) in upper respiratory tract mucosa in a group of pre-school children

Szydłowski, Jarosław; Jończyk‐Potoczna, Katarzyna; Pucher, Beata; Buraczyńska-Andrzejewska, Beata; Prauzinska, Magdalena; Kolasińska-Lipńska, Jagoda; Krauss, Hanna; Piątek, Jacek; Żukiewicz-Sobczak, Wioletta

doi:10.5604/12321966.1129940

Cited by 9 publications

(15 citation statements)

References 18 publications

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“…In the current study positive samples for hMPV was 12 (9.1%), This ratio may be considered lower than similar studies [ 26 ] [ 27 ] [ 28 ] and that can be explained by that child included in our study were enrolled from the patient presenting by ILI symptoms and the hMPV is more common in hospitalized children with pneumonia.…”

Section: Discussioncontrasting

confidence: 67%

Respiratory Viruses and Atypical Bacteria Co-Infection in Children with Acute Respiratory Infection

Baroudy¹,

Rifay²,

Hamid³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Acute respiratory infections (ARI) are one of the prevalent pediatric diseases. Coinfections of respiratory viruses and atypical bacterial respiratory pathogens are common.AIM:This study aimed to determine the prevalence of co-infection between respiratory pathogens including viruses, bacteria and atypical bacteria in a sample of Egyptian children presenting with symptoms of acute respiratory tract infection.METHODS:This one-year prospective cohort study conducted in Abo El Rish Pediatric Hospital, Cairo University over one year included children presenting with symptoms of acute respiratory infection. Enrolled children were subjected to nasopharyngeal swabs or throat swabs and then processed to detect viral, bacterial and atypical bacterial causative agents by culture), retrotranscription polymerase, Monoplex polymerase chain reaction (PCR) and Multiplex PCR.RESULTS:Viral etiological agents were detected in 20 cases (20.8%), while 76 patients (79.2%) had no definite viral aetiology. The most abundant virus detected was Rhinovirus in 36 (27.3%), followed by 21 (15.9%) were positive for RSV, 12 (9.1%) were positive for HMPV, 6 (4.5%) were positive for adenovirus and 3 (2.3%) were positive for influenza B. For Atypical bacterial causes Mycoplasma were positive for 9 (6.8%) cases and one case was positive for Bordetella parapertussis. Viral and atypical bacteria Co infection were detected in 14 (10.6%) of cases.CONCLUSION:These results suggest that coinfection with bacteria or atypical bacteria in children with acute respiratory tract infection is common and this co-infection can induce serious illness. The multiplex reverse-transcriptase polymerase chain reaction should become an essential tool for epidemiological studies and can fill the gap between clinical presentation and definitive diagnosis.

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Section: Discussioncontrasting

confidence: 67%

Respiratory Viruses and Atypical Bacteria Co-Infection in Children with Acute Respiratory Infection

Baroudy¹,

Rifay²,

Hamid³

et al. 2018

Open Access Maced J Med Sci

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“…2014 untersuchte eine polnische Studie die Prävalenz von HPV bei 97 gesunden Vorschulkindern im Alter zwischen drei und fünf Jahren [18]. Den Kindern wurden orale Abstriche genommen und auf das Vorhandensein von HPV geprüft.…”

Section: Hpv Bei Kindernunclassified

“…Den Kindern wurden orale Abstriche genommen und auf das Vorhandensein von HPV geprüft. Bei knapp 20 % der Kinder wurde eine Infektion mit den HPV-Typen 6 und/oder 11 im Plattenepithel des oberen Atemtrakts festgestellt, darunter aber keine krebserregenden HR-HPV-Typen [18]. Die Forscher stellten keinen Zusammenhang zwischen dem Vorhandensein einer HPV-Infektion sowie Geburtsart und -zeitpunkt oder dem Geburtsgewicht des Kindes fest [18].…”

Section: Hpv Bei Kindernunclassified

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Humane Papillomaviren (HPV): Erreger, Impfung und Praxishinweise

Höhne¹,

Klug²

2018

Pädiatrie up2date

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“…The risk of transmission is elevated among young primiparous mothers with condylomas [12]. Despite the low incidence of JORRP, the presence of asymptomatic HPV is relatively common in the respiratory tracts of children [13, 14]. Therefore, other factors have to contribute to the pathogenesis of JORRP, during either the activation or reactivation of HPV.…”

Section: Introductionmentioning

confidence: 99%

Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis

Formánek

Komínek

Jančatová

et al. 2019

BioMed Research International

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Introduction. Human papillomavirus (HPV) causes juvenile-onset recurrent respiratory papillomatosis (JORRP). Although HPV is common in children, the prevalence of JORRP is low. It is likely that other factors contribute to the pathogenesis of JORRP, during either activation or reactivation of a latent HPV infection. There is evidence that laryngopharyngeal reflux (LPR) might be such a risk factor for adult-onset recurrent respiratory papillomatosis. This study investigated if LPR might also be a risk factor for JORRP. Materials and Methods. Children with JORRP of the larynx that required microlaryngoscopy at a tertiary referral hospital were included in this prospective case-series study from November 2015 to November 2017. Using immunohistochemistry, HPV infection and pepsin associated with LPR were diagnosed from laryngeal biopsies. Results. Eleven children (aged 4-14 years) were analyzed. No patient had a history of immunodeficiency or tobacco smoke exposure. All patients underwent at least three previous surgeries due to JORRP and had been vaccinated against HPV in the past. Five children were treated using antivirotics and immunomodulators. The only known maternal risk factor was that three mothers were primiparous. All 11 samples were infected with HPV (type 6 or 11). Pathologic LPR was diagnosed in 5/11 children (45.5%). Conclusion. LPR may be a risk factor for JORRP, contributing to its development by activating or reactivating a latent HPV infection. Results are in accordance with those from our previous study in adults.

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Prevalence of Human Papillomavirus (HPV) in upper respiratory tract mucosa in a group of pre-school children

Cited by 9 publications

References 18 publications

Respiratory Viruses and Atypical Bacteria Co-Infection in Children with Acute Respiratory Infection

Respiratory Viruses and Atypical Bacteria Co-Infection in Children with Acute Respiratory Infection

Humane Papillomaviren (HPV): Erreger, Impfung und Praxishinweise

Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis

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