Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis

Abogunrin, Seye; Tanna, Gian Luca Di; Keeping, Sam; Carroll, Stuart; Iheanacho, Ike

doi:10.1186/1471-2407-14-968

Cited by 82 publications

(77 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this report, HPV prevalence in OSCC was 26.9%, being markedly higher than that (17.5%) reported in the analysis of Ndiaye et al [31]. HPV prevalence was also higher in Eastern than in Western Europe (34.7 vs. 21.3%) [30]. All HPV type-specific meta-analyses agreed in that the HPV16 genotype is the most prevalent HPV in OSCC, with prevalences of 50–60%, 40%, and 10.7% in the Asian-Pacific region, China, and Europe, respectively [29, 31, 32].…”

Section: Hpv In Hnsccmentioning

confidence: 42%

See 1 more Smart Citation

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Syrjänen

2019

Acta Cytologica

View full text Add to dashboard Cite

Background: The association of human papillomavirus (HPV) with head and neck squamous cell carcinoma (HNSCC) was first described in 1982–1983 by the authors of this review. Prompted by this discovery 35 years ago, an entirely new field of HPV research has emerged, resulting in a paradigm shift from smoking and alcohol as the only etiological factors to confirmation of HNSCC as an important group of HPV-related human malignancies. Summary: In this review, the authors first describe the scope (i.e., HNSCC) by the anatomic sites of the tumors. Their important site-specific differences in epidemiology are emphasized, and the misconceptions caused by the adopted practice of pooling all tumors from these divergent anatomic sites as a single entity (HNSCC) are pinpointed. The convincing evidence of the established risk factors (smoking and alcohol) is briefly addressed, before entering in the discussion on the causal role of HPV in HNSCC pathogenesis. The global HPV prevalence in different subsets of HNSCC is summarized using the data extracted from all meta-analyses published since 2010. Of all HNSCC subsets, oropharyngeal SCC has an HPV profile distinct form all the other subsets, and the possible mechanisms explaining this intimate association with HPV are discussed. Key Messages: Recent global trends show a constant increase in HNSCC rates particularly among younger age groups. The evidence on cigarette smoking and alcohol consumption as the prime risk factors of HNSCC is overwhelming. During the past 35 years, however, increasing evidence has accumulated implicating an important causal role of HPV in HNSCC. These data have important clinical implications, HPV detection and tailored treatment strategies for HPV-positive HNSCCs currently being an integral part of the oncological management practices of HNSCC.

show abstract

Section: Hpv In Hnsccmentioning

confidence: 42%

“…Only one meta-analysis on HPV prevalence in OSCC covers Europe [30], spanning the period 2002–2012. In this report, HPV prevalence in OSCC was 26.9%, being markedly higher than that (17.5%) reported in the analysis of Ndiaye et al [31].…”

Section: Hpv In Hnsccmentioning

confidence: 99%

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Syrjänen

2019

Acta Cytologica

View full text Add to dashboard Cite

show abstract

“…3 The so-called HPV epidemic is most prominent in patients of Northern European and North American origin, whereas other areas of the world still see few HPVassociated tumors. [4][5][6] In studies that include an assessment of HPV status, a shift in the traditional risk factors is nearly universally noted: viral-associated tumors are seen in younger populations that have lymph node-positive oropharyngeal carcinomas and lower rates of smoking. 7 Having said this, most patients with HPV-associated oropharyngeal carcinoma are still men in their 50s who have a smoking history, and true nonsmokers constitute only a minority.…”

Section: Introductionmentioning

confidence: 99%

Genetic Landscape of Human Papillomavirus–Associated Head and Neck Cancer and Comparison to Tobacco-Related Tumors

Hayes

Waes

Seiwert

2015

JCO

124

111

View full text Add to dashboard Cite

Head and neck cancer is the fifth most common cancer worldwide. It is often amenable to curative intent therapy when localized to the head and neck region, but it carries a poor prognosis when it is recurrent or metastatic. Therefore, initial treatment decisions are critical to improve patient survival. However, multimodality therapy used with curative intent is toxic. The balance between offering intensive versus tolerable and function-preserving therapy has been thrown into sharp relief with the recently described epidemic of human papillomavirus-associated head and neck squamous cell carcinomas characterized by improved clinical outcomes compared with smokingassociated head and neck tumors. Model systems and clinical trials have been slow to address the clinical questions that face the field to date. With this as a background, a host of translational studies have recently reported the somatic alterations in head and neck cancer and have highlighted the distinct genetic and biologic differences between viral and tobacco-associated tumors. This review seeks to summarize the main findings of studies, including The Cancer Genome Atlas, for the clinician scientist, with a goal of leveraging this new knowledge toward the betterment of patients with head and neck cancer.

show abstract

“…In our first case, smoking was the biggest risk factor leading to synchronous esophageal squamous and lung adenocarcinoma both of which have been associated with smoking [5]. Tobacco and alcohol consumption can lead to high incidence of tongue and oral mucosal cancer [6]. In some head and neck cancers, HPV infection can be a common trigger leading to multiple primary cancers.…”

Section: Discussionmentioning

confidence: 99%

“…HPV-16 and HPV-18 have been recognized as the culprit in oropharyngeal, laryngeal, tonsillar, anal and cervical cancers. This infection has also been a target for developing anti-cancer vaccination [6]. …”

Section: Discussionmentioning

confidence: 99%

Case series of multiple primary cancers in single individuals: diagnostic and therapeutic dilemmas

Malik

Ali

Durrani

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

View full text Add to dashboard Cite

Background and Objectives: Cancer recurrence represents treatment failure; the development of new primary tumors is suggestive of persistent exposure to etiological risk factors or genetic predisposition due to mutations in multiple cell lines. Case presentation/Design/Methods: The first case is a 65-years-old Caucasian male who presented with esophageal and lung cancer diagnosed synchronously. Smoking was the common risk factor for both cancers, underscoring field cancerization. The diagnosis and management was a challenge and different from either cancer presenting alone. Multidisciplinary approach was used and led to good outcomes.The second case is a 72-years-old Caucasian male presenting a rare dilemma of genetic mutation leading to multiple primary gastrointestinal cancers in a single individual. The gene explaining this group of cancers has not been diagnosed yet and the field needs to be explored further. Conclusion: Multiple primary cancers can be secondary to a common environmental risk factor or genetic mutations.

show abstract

Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis

Cited by 82 publications

References 61 publications

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Genetic Landscape of Human Papillomavirus–Associated Head and Neck Cancer and Comparison to Tobacco-Related Tumors

Case series of multiple primary cancers in single individuals: diagnostic and therapeutic dilemmas

Contact Info

Product

Resources

About