Prevalence of human papillomavirus in cervical cancer: A multicenter study in China

Lo, KW; Wong, Y. F.; Chan, May K.M.; Li, J.; Poon, Jtc; Wang, Vivian W.; Zhu, Shun; Zhang, T.M.; He, Zhi; Wu, Qinjiao; Li, G.D.; Tam, John S.; Kahn, Tomas; Lam, Paul; Cheung, Tak‐Hong; Chung, Tony K.H.

doi:10.1002/ijc.10506

Cited by 80 publications

(83 citation statements)

References 26 publications

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“…The very low rate of HPV-16 infection in cervical cancer is contrary to the previous reports of high infection rate of this high risk type in different populations ( Table 2 ). 17,19,21 However, it is comparable to the results of some other studies. 13,18,22 The study of Castellsague in Mozambique 13 has shown that there may be differences in the dominant HPV types in different populations and regions.…”

Section: Discussionsupporting

confidence: 87%

“…In total, 87.1% of studied samples were positive for the presence of HPV DNA, which was comparable with the results of some previous studies in Danish, Belgian, Brazilian and Chinese patients. [17][18][19][20] Genotyping for HPV-16 and HPV-18 revealed that 26.7% of HPV positive samples were HPV-16 DNA positive, however, none of them were positive for HPV-18 DNA. The very low rate of HPV-16 infection in cervical cancer is contrary to the previous reports of high infection rate of this high risk type in different populations ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

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High risk HPV types in southern Iranian patients with cervical cancer

Farjadian

Asadi

Doroudchi

et al. 2003

Pathol. Oncol. Res.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

High risk HPV types in southern Iranian patients with cervical cancer

Farjadian

Asadi

Doroudchi

et al. 2003

Pathol. Oncol. Res.

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“…The number of cases studied from Africa and Europe/North America was about half of the number studied from Central/South America and south Asia, and large regions such as China were not included. Thus, the prevalence of HPV-58, e.g., which has been reported to be high in China, 24 Korea 25 and some regions of Africa, 26 may be underestimated in our study.…”

Section: Discussionmentioning

confidence: 54%

Against which human papillomavirus types shall we vaccinate and screen? the international perspective

Muñóz

Bosch

Castellsagué

et al. 2004

Intl Journal of Cancer

968

669

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At least 15 types of HPV have been associated with cervical cancer, but current HPV vaccines confer only type-specific immunity. To determine geographic variations in the HPV type distribution in cervical cancer, we carried out a pooled analysis of data from an international survey of HPV types in cervical cancer and from a multicenter case-control study, both co-coordinated by the IARC. Study cases were 3,607 women with incident, histologically confirmed cervical cancer recruited in 25 countries. HPV DNA detection and typing in cervical cells or biopsies were centrally done using PCR assays. Estimates of the potential number of cases prevented by HPV type-specific vaccines and changes in the validity of different HPV screening cocktails were calculated. HPV DNA was detected in 96% of specimens, and 30 different types were detected. Key words: cervical cancer; human papillomavirus; human papillomavirus geographic distributionCervical cancer is the second most common cancer in women worldwide but the first in most developing countries, where 80% of cases occur. 1 Molecular epidemiologic evidence accumulated over the past 20 years clearly indicates that certain HPV types are the central and probably necessary cause of cervical cancer. [2][3][4] Over 100 HPV types have been identified, and about 40 are known to infect the genital tract. 5 To assess the geographic distribution of HPV types in invasive cervical cancer and the risk linked to the various HPV types, the IARC carried out an international survey of cervical cancer specimens in 22 countries 4,6 and a multicenter case-control study in 11 countries around the world. [7][8][9][10][11][12][13][14][15] These studies were carried out using the same protocol and sensitive PCR assays for the detection of HPV DNA in a central laboratory.HPV prophylactic vaccines for the most common types (HPVs 16 and 18) are now being tested in various populations with promising results as they have been shown to be safe and to induce high titers of neutralizing antibodies that prevent HPV infection and cervical intraepithelial neoplasia (CIN). 16 -18 Although there is some evidence of cross-reactivity among certain HPV types, 19 this appears to account for Ͻ1% of antibody reactivity, indicating that protection to infection is type-specific. Effective HPV vaccines should then be polyvalent and should contain the HPV types responsible for most cervical cancers. It is thus of great importance to assess if there are significant differences in the geographic distribution of HPV types causing cervical cancer. If this is the case, their description would provide the rationale for considering tailoring vaccine products to the HPV types prevalent in a given geographic area vs. producing a common vaccine suitable to the worldwide distribution of HPV types. Previous studies have revealed some geographic differences in HPV type distribution, but the size of individual studies and the validity of the PCR testing systems used precluded delineation of clear patterns. 4,6 -15,20 HPV screening...

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“…The corresponding percentages in other IARC HPV prevalence surveys in different continents were 32.6% in Europe, 22.5% in Asia, 22.0% in Latin America, and 12.2% in Africa , making the proportion of HPV16-positive women in our present populationbased study among the highest recorded worldwide. In a study of 809 cervical cancer cases from four areas in China, a relatively high proportion (66.9%) were positive for HPV16 (Lo et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus infection in Shanxi Province, People's Republic of China: a population-based study

et al. 2006

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To investigate the prevalence of, and risk factors for, cervical infection with human papillomavirus (HPV) in the rural province of Shanxi, People's Republic of China, which has relatively high cervical cancer mortality rates, we interviewed and obtained cervical cell samples from 662 women aged 15 -59 years. A total of 24 different HPV types were identified using a GP5 þ /6 þ -based PCR assay able to detect 44 different HPV types. Human papillomavirus prevalence was 14.8% overall and 9.6% among women without cervical abnormalities (14.2 and 8.9%, respectively, age standardised to the world standard population). Multiple-type infections accounted for 30.6% of all infections. By far the most commonly found type was HPV16 (5.7% of all women and 38.8% of HPV-positive women), followed by HPV 58, 52, 33 and 18. Unlike most previous studies published, HPV prevalence was lower among women younger than 35 years (8.7%) than those older than 35 years (17.8%). High-risk HPV types predominated in all age groups. Although low-risk HPV types were rare in young women, they became more common with increasing age. 92.3% of women with cervical intraepithelial neoplasia grade 3 were infected with high-risk HPV types, but none with low-risk types only. No significant difference in HPV positivity was observed by educational level, sexual habits, reproductive history or use of contraceptive methods in this rural lowincome Chinese population.

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Prevalence of human papillomavirus in cervical cancer: A multicenter study in China

Cited by 80 publications

References 26 publications

High risk HPV types in southern Iranian patients with cervical cancer

High risk HPV types in southern Iranian patients with cervical cancer

Against which human papillomavirus types shall we vaccinate and screen? the international perspective

Human papillomavirus infection in Shanxi Province, People's Republic of China: a population-based study

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