Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer—systematic review and meta‐analysis of trends by time and region

Mehanna, Hisham; Beech, T.J.; Nicholson, T.; El‐Hariry, Iman; McConkey, Christopher C.; Paleri, Vinidh; Roberts, Sally

doi:10.1002/hed.22015

Cited by 731 publications

(639 citation statements)

References 18 publications

Supporting

Mentioning

577

Contrasting

Unclassified

Order By: Relevance

“…Mucosal HPV types found preferentially in precancerous and cancerous lesions have been designated as 'high-risk' types and these include types 16,18,31,33,34,35,39,45,51,52,56,58,59, 66, 68, and 70. Mucosal HPVs found in benign genital warts and other non-malignant lesions are generally labeled as 'low-risk' types, the most important ones being HPV 6,11,42,43, and 44 [1,2].…”

Section: Human Papillomaviruses (Structure and Classification)mentioning

confidence: 99%

“…Seven years later, in 1983, we published the first evidence suggesting that a subgroup (some 20 %) of oral cancers is associated with HPV, based on detection of HPV structural proteins in these lesions using an antibody prepared against pooled HPV types [39]. We subsequently identified HPV types 11, 16 and 18 in these samples [40][41][42][43][44][45][46][47][48][49]. This concept has now been well accepted, and a growing body of evidence is supporting that approximately 20 % of oral cancers and 60-80 % of oropharyngeal cancers are caused by HPV [41][42][43][44].…”

Section: Hpv and Head And Neck Cancer (Hnscc)mentioning

confidence: 99%

“…We subsequently identified HPV types 11, 16 and 18 in these samples [40][41][42][43][44][45][46][47][48][49]. This concept has now been well accepted, and a growing body of evidence is supporting that approximately 20 % of oral cancers and 60-80 % of oropharyngeal cancers are caused by HPV [41][42][43][44]. In 2011, the International Agency of Research of Cancer (IARC), classifying both chemical and biological carcinogens to humans, declared that there is sufficient evidence that HPV-16 is causally associated with oral cancer [45].…”

Section: Hpv and Head And Neck Cancer (Hnscc)mentioning

confidence: 99%

See 2 more Smart Citations

Biology of Human Papillomavirus Infections in Head and Neck Carcinogenesis

Rautava

Syrjänen

2012

Head and Neck Pathol

127

135

View full text Add to dashboard Cite

Section: Human Papillomaviruses (Structure and Classification)mentioning

confidence: 99%

Section: Hpv and Head And Neck Cancer (Hnscc)mentioning

confidence: 99%

Section: Hpv and Head And Neck Cancer (Hnscc)mentioning

confidence: 99%

See 1 more Smart Citation

Biology of Human Papillomavirus Infections in Head and Neck Carcinogenesis

Rautava

Syrjänen

2012

Head and Neck Pathol

127

135

View full text Add to dashboard Cite

“…Prevalence in HPV positive oropharyngeal SCC has increased significantly in North America and Europe, and the significant gap that existed before 2000 between both continents (50.7 % vs. 35.3 %, p = 0.008) has disappeared (now 69.7 vs. 73 %, respectively, p = .8). Prevalence in non-oropharyngeal SCC (21.8 %, 95 % CI 18.9-25.1 %) has not increased over time (p = .97) [32]. In contrast to the high percentage of HPV related tumors of the oropharyngeal region, HPVpositive premalignant lesions are extremely rare findings in tonsillectomy specimens [33,34].…”

Section: Important Differences Between Cervical and Head And Neck Silsmentioning

confidence: 90%

Current Views and Perspectives on Classification of Squamous Intraepithelial Lesions of the Head and Neck

Gale

Zidar

Poljak

et al. 2014

Head and Neck Pathol

View full text Add to dashboard Cite

The current state in the field of classifying oral and laryngeal precursor lesions, as proposed in the WHO 2005 Blue Book is not ideal. The results of various interobserver studies have shown that the currently used grading systems, with different basic concepts and different terminology, cannot continue to be reliably used in the future. The different etiology of cervical and head and neck precursor lesions requires a classification designed to cater to the specificities of the head and neck region. Trying to harmonize different classifications of the oral and laryngeal precursor lesions, we have proposed four crucial steps to set up a unified classification of squamous intraepithelial lesions (SILs): (a) the classification should contain two grades, low-grade and high-grade lesions and, specifically for the larynx, an additional grade-carcinoma in situ (CIS) which must be separated from high-grade laryngeal SILs; (b) the terminology should be unified; our preference is for the term SIL over squamous intraepithelial neoplasia; (c) all leading morphological criteria for low-and highgrade lesions, as well as for CIS, should be clearly defined; (d) agreement between clinicians and pathologists should be achieved on the most appropriate choice of treatment of different grades of SILs in separate head and neck areas.

show abstract

“…SCC of the lip is found on the lower lip in 95 % of cases, whereas BCC is often located on the upper lip [4]. The risk of lip cancer increases with UV exposure, smoking and some specific genetic diseases or viral infection [5].…”

Section: Introductionmentioning

confidence: 99%

Retrospective Outcome Analysis of 39 Patients Who Underwent Lip Surgery for Cutaneous Carcinoma

Guyon

Bosc

Lange

et al. 2016

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

Purpose The treatment of lip carcinomas needs tumor surgical resection with safety margins respect. The aim of this study was to report the oncologic and aesthetic/functional outcomes of a retrospective monocentric case series of 39 patients treated for cutaneous lip cancer. Methods This retrospective study assessed 56 patients who were treated for a lip carcinoma between 2008 and 2012 and included 39 patients with cutaneous lip basal cell carcinoma or squamous cell carcinoma. Clinical, surgical and pathological data were reviewed, and patients were interviewed for follow-up data. A comparison was made between the marked surgical margins and the margins observed under microscopy after histologic process. Results The most frequent tumor type was basal cell carcinoma in 69.2 %. The measured surgical margins were superior to the histological margins in 24 cases (61.5 %) and were inferior in 13 cases (33.3 %). Overall survival and recurrence-free survival rates at 1 year were 97.5 and 95 % respectively. Conclusion Differences between the surgical margins and the final histologic margins were the main finding of this retrospective study. These differences were attributed to surgical practices and modification during the histological process. Nevertheless, we did not observe a higher rate of recurrence or death in our study than in literature.

show abstract

Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer—systematic review and meta‐analysis of trends by time and region

Abstract: The sharp increase in the proportion of HPV-positive OPC over the last decade has occurred at a faster rate in Europe compared with that in North America. In contrast, the relatively low prevalence of HPV in non-OPC remains unchanged.

Cited by 731 publications

References 18 publications

Biology of Human Papillomavirus Infections in Head and Neck Carcinogenesis

Biology of Human Papillomavirus Infections in Head and Neck Carcinogenesis

Current Views and Perspectives on Classification of Squamous Intraepithelial Lesions of the Head and Neck

Retrospective Outcome Analysis of 39 Patients Who Underwent Lip Surgery for Cutaneous Carcinoma

Contact Info

Product

Resources

About