Prevalence of human papillomavirus in the oral cavity of an indigenous community from Southwest México

Garza-Ramos, Myriam Angélica De La; Urrutia-Baca, Víctor Hugo; Urbina-Ríos, Cynthia Sofía; Robayo, Dabeiba Adriana García; Tamez‐Guerra, Patricia; Gómez-Flores, Ricardo

doi:10.1016/j.meegid.2020.104283

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…They reported an oral HPV infection prevalence of 10.7% (high-risk HPV prevalence of 6.4%) at baseline in 636 people who were β-globin positive. In our study, the most prevalent HPV types at baseline were those associated with Heck disease (multifocal epithelial hyperplasia; 207/910, 23% of the HPV types found)—a relatively benign and rare condition caused by oral HPV 13 or 32 infection that is more prevalent among Indigenous populations [ 33 - 35 ]. Clinically, Heck disease presents as soft, distinct, mostly multiple, and smooth papules or nodules having the same color as the surrounding mucosal epithelium (a “cobblestone” appearance), predominantly affecting the lower and upper labial mucosa and tongue.…”

Section: Resultsmentioning

confidence: 99%

The Indigenous Australian Human Papillomavirus (HPV) Cohort Study 2, Continuation for 5 to 10 Years: Protocol for a Longitudinal Study

Hedges¹,

Sethi²,

Garvey³

et al. 2023

JMIR Res Protoc

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Background Human papillomavirus (HPV) infection, a common sexually transmitted disease, is associated with cancers of the cervix, vulva, vagina, penis, anus, and head and neck. Oropharyngeal squamous cell carcinoma (OPSCC; throat cancer) is a type of cancer involving the head and neck area that is rapidly increasing across the globe. There are higher rates of OPSCC among Indigenous populations relative to non–Indigenous Australian populations, although the HPV-attributable fraction remains unknown. For the first time at a global level, we plan to extend an Indigenous Australian adult cohort to monitor, screen, and ultimately prevent HPV-associated OPSCC and to undertake extensive cost-effectiveness modelling around HPV vaccination. Objective This study aims to (1) extend follow-up to a minimum of 7 years post recruitment to describe the prevalence, incidence, clearance, and persistence of oral HPV infection; and (2) conduct clinical examinations of the head and neck, oral cavity, and oropharynx and collect saliva samples for early-stage OPSCC testing. Methods We will continue to implement a longitudinal design for the next study phase, where we will ascertain the prevalence, incidence, clearance, and persistence of oral HPV infection at 48, 60, and 72 months; undertake clinical examinations/saliva assessments to detect early-stage OPSCC; and refer for treatment. The primary outcome measures are changes in oral HPV infection status, biomarker measures of early HPV-related cancer, and clinical evidence of early-stage OPSCC. Results Participant 48-month follow-up will commence in January 2023. The first results are expected to be submitted for publication 1 year after 48-month follow-up begins. Conclusions Our findings have potential to change the way in which OPSCC among Australian Indigenous adults is managed, with desired impacts including cost-savings on expensive cancer treatments; improved nutritional, social, and emotional outcomes; and improved quality of life for both Indigenous adults and the Indigenous community more broadly. Continuing a large, representative Indigenous adult cohort to track oral HPV infection and monitor early OPSCC is essential to yield critical information to include in the management armamentarium of health and well-being recommendations for Australia’s First Nations. International Registered Report Identifier (IRRID) PRR1-10.2196/44593

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Section: Resultsmentioning

confidence: 99%

The Indigenous Australian Human Papillomavirus (HPV) Cohort Study 2, Continuation for 5 to 10 Years: Protocol for a Longitudinal Study

Hedges¹,

Sethi²,

Garvey³

et al. 2023

JMIR Res Protoc

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“…HPV 16 is an etiological factor in cervical cancer (5,40) due the expression of E6 and E7 oncoproteins that enhance the cell cycle in the upper epithelial layers of the cervix (41)(42)(43), which, in some cases, can stimulate the proliferation of infected basal cells and eventually lead to neoplasia (12). These viral proteins are able to bind and inactivate the tumor suppressor genes such as p53 and retinoblastoma (Rb), among others, resulting in increased survival and proliferation to induce immortalization of cervical cells (44,45).…”

Section: Discussionmentioning

confidence: 99%

Effect of HPV 16 E6 Oncoprotein Variants on the Alterations of the Proteome of C33A Cells

Garibay‐Cerdenares

Sánchez-Meza

Encarnación‐Guevara³

et al. 2021

Cancer Genomics Proteomics

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“…A study in Mexico showed a prevalence of oral HPV infection of 12.1%. 51 Unfortunately, the absence of data by state makes it difficult to incorporate this variable in this type of study at this time. However, prophylactic vaccines may be useful in the prevention of squamous cell carcinoma of the oral cavity associated with HPV, but prospective studies on this topic are lacking.…”

Section: Discussionmentioning

confidence: 99%

Effect of Human Development Index and other socioeconomic factors on mortality-to-incidence ratio of lips and oral cavity cancer in Mexican states: an ecological study

et al. 2021

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ObjectivesTo assess the association between the Human Development Index (HDI) and covariates on the mortality-to-incidence ratio (MIR) of lips and oral cavity cancer (LOCC) in Mexico.DesignEcological study.SettingData from 32 Mexican states for year 2019.ParticipantsData set of male and female populations from Mexico.ExposuresSocioeconomic conditions based on HDI and covariates related to healthcare system capacity (total health spending per capita, school dropout and ratio of medical personnel in direct contact with patients).Primary and secondary outcome measuresMIR of LOCC by state and sex was calculated from the Global Burden of Disease Study website for year 2019. Data for calculating HDI 2019 by state and covariates were obtained from the National Institute of Statistics and Geography. A multiple regression model was constructed to measure the effects of HDI and covariates on LOCC-MIR.ResultsAmong the states with the highest HDI (>0.780), Colima had the highest aged-standardised rates per 100.000 in men for incidence (5.026) and mortality (3.118). The greatest burden of the disease was found on men, with the highest Men:Women MIR in Colima (3.10) and Baja California Sur (2.73). The highest MIR (>0.65) was found among the states with the lowest HDI (Oaxaca and Chiapas). For each unit of increase of the HDI there was a decrease in the LOCC- MIR of −0.778, controlling for the covariates. The most suitable regression model explained the 57% (F (p): 0.000) of the variance.ConclusionsMen were most affected by LOCC in Mexican states. The highest MIRs of LOCC were found in the states with the highest HDI. But a worse prognosis of the disease, expressed as a higher MIR, is expected in contexts with lower HDI in the country, even with lower MIRs.

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Prevalence of human papillomavirus in the oral cavity of an indigenous community from Southwest México

Cited by 12 publications

References 29 publications

The Indigenous Australian Human Papillomavirus (HPV) Cohort Study 2, Continuation for 5 to 10 Years: Protocol for a Longitudinal Study

The Indigenous Australian Human Papillomavirus (HPV) Cohort Study 2, Continuation for 5 to 10 Years: Protocol for a Longitudinal Study

Effect of HPV 16 E6 Oncoprotein Variants on the Alterations of the Proteome of C33A Cells

Effect of Human Development Index and other socioeconomic factors on mortality-to-incidence ratio of lips and oral cavity cancer in Mexican states: an ecological study

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