Prevalence of Human Papillomavirus Infection in Women in Portugal

Pista, Ângela; Oliveira, Carlos; Cunha, Maria João; Paixão, Maria Teresa; Real, O

doi:10.1097/igc.0b013e31821dd3b2

Cited by 43 publications

(25 citation statements)

References 24 publications

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“…In our study, in spite of the limited sample size, we found no difference in ST and MT prevalence comparing women with CIN1 with those with CIN2 or worse. By contrast, Pista et al [12], studying Portuguese women, found a significant association between MT infections and disease severity. Argyri et al [11] also found that MT infections were significantly more common in women with squamous intraepithelial lesions compared with healthy women.…”

Section: Discussionmentioning

confidence: 87%

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A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

et al. 2014

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BackgroundCervical cancer ranks third in prevalence and fourth as cause of death in women worldwide. In Brazil, 17,540 women were diagnosed in 2012 with the disease. Persistent infection with high-risk HPV types is a necessary condition for the development of pre-invasive and invasive cervical neoplasia. Currently, over 100 HPV types have been identified, but HPV16 and 18 are recognized as the mayor culprits in cervical carcinogenesis. Our objective was to assess the relationships between single- (ST) and multiple-type (MT) HPV infections with patients’ age and lesion pathological status.Methods328 patients with either squamous or glandular intraepithelial or invasive cervical lesion were selected. All subjects were tested for HPV genotypes with reverse hybridization for 21 high- (hr-HPV) and 16 low-risk (lr-HPV) probes. Prevalence of ST and MT HPV infections was compared across histological types and age strata.Results287 (87%) women had at least one HPV type detected and 149 (52%) had MT infections. The most prevalent HPV type was HPV16, present in 142 cases (49% of all HPV-positive cases), followed by HPV58, 52, 31, 35 and 33. HPV18, in single or multiple infections, occurred in 23 cases (8% of hr-HPV cases). Almost all glandular lesions were associated with HPV16 and 18 alone. Multiple infections were significantly more prevalent in squamous than in glandular lesion for HPV16 and 18 (P = 0.04 and 0.03 respectively). The prevalence of MT infections followed a bimodal distribution; peaking in women younger 29 years and in those aged 50 to 59.ConclusionsOur data indicate that prevention strategies for pre-invasive and invasive squamous lesions should be focused on HPV16 and a few alpha-9 HPV types. It is clear to us that in young women, prophylaxis must cover a large amalgam of HPV types beyond classic HPV16 and 18.

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Section: Discussionmentioning

confidence: 87%

“…MT-HPV has been observed in women with persistent infections, but its relationship with cervical carcinogenesis has not been established [12]. Importantly, there is no consensus whether MT-HPV infections harbouring HPV16/18 and other HPV types are associated with higher risk of carcinogenesis than ST-HPV16/18 infections [13].…”

Section: Introductionmentioning

confidence: 99%

A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

et al. 2014

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“…Interestingly, Jaisamrarn found a paradoxical result that co-infection could increase the risk of progression to a CIN but also increase the chance of clearance [ 13 ]. Pista, studying Portuguese women, found a significant association between multiple infections and disease severity [ 14 ]. Balbi et al concluded that the infection with multiple HPV types is a significant risk factor for high-grade CIN [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Distribution of HPV Genotype in Invasive Cervical Carcinoma and Cervical Intraepithelial Neoplasia in Zhejiang Province, Southeast China: Establishing the Baseline for Surveillance

Zhou

Yuan

et al. 2015

IJERPH

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Human papillomavirus (HPV) are firmly established as the principal causative agent for cervical carcinoma. Current vaccines may provide some protection for women from cervical carcinoma linked to HPV genotype 16 and 18. This may be the best vaccine for Western women, but the geographical variation in HPV distributions may not make it the most appropriate vaccine for China or Asia. This study provided an observational, retrospective, hospital-based cross-sectional study on the distribution of HPV genotypes among 5410 women with invasive cervical cancer (ICC) or cervical intraepithelial neoplasia (CIN). Overall, the positive rates of the four HPV types included in current prophylactic vaccines were counted, the two high-risk types (HPV-16 and -18) covered by current vaccines represented 66.9% of women with squamous cancer, 55.0% with adenocarcinoma, 64.9% with adenosquamous carcinoma and 77.4% of other type ICC, as well as 59.5% of CIN III, 45.0% of CIN II and 38.1% of CIN I cases. As expected, two low-risk types (HPV-6 and -11) included in the quadrivalent vaccine did not show good coverage data. Particularly worth mentioning is the fact that the addition of HPV-52 and -58 to the vaccine cocktail would increase cancer protection in our population, potentially preventing up to beyond 16% of squamous/adenosquamous carcinoma and other type of cervical cancers, and 7.75% of adenocarcinomas. It might also potentially reduce the rate of CIN III by a further 28.6% and CIN II and I by a third. This study established the baseline for surveillance in Zhejiang Province, and provides data for further vaccine designs: a quadrivalent HPV vaccine covering HPV-16/-58/-18/-52, would be more welcome in our region in the forthcoming year compared to the currently available vaccine.

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“…The risk of HR-HPV infection was increased in women who reported at least two sexual partners. The CLEOPATRE study included women aged 18–64 years in Spain and Portugal [22,23]. The highest prevalence of HR-HPV was observed in women aged 18–24 years (27.0–28.8%) [23].…”

Section: Discussionmentioning

confidence: 99%

“…The CLEOPATRE study included women aged 18–64 years in Spain and Portugal [22,23]. The highest prevalence of HR-HPV was observed in women aged 18–24 years (27.0–28.8%) [23]. The lifetime number of sexual partners was a strong predictor of HPV infection (OR 5.44 for 5–10 partners versus one partner; p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of high-risk HPV types and associated genital diseases in women born in 1988/89 or 1983/84 – results of WOLVES, a population-based epidemiological study in Wolfsburg, Germany

et al. 2013

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BackgroundHigh-risk human papilloma virus (HR-HPV) infection is associated with the development of cervical cancer. HPV vaccination reduces the risk of developing malignant lesions and is expected to change the dynamics of HPV transmission. Data from non-vaccinated women may provide an important benchmark to allow the impact of HPV vaccination programs to be assessed.This study was designed to prospectively determine the changing dynamics of HR-HPV infection and associated genital diseases in young women, most of whom were non-vaccinated.MethodsData from a population-based cohort study, comprising women of two predefined birth cohorts (women born in 1983/84 or 1988/89), were analyzed between 19 October 2009 and 31 December 2010 to determine risk factors for high-risk HPV infection and the association between specific HR-HPV types and atypical Pap smear test results. HPV status was determined by Hybrid Capture 2 (HC2) assay and genotyping.ResultsThe prevalence of HR-HPV was 22.8% in the 1983/84 cohort (150/659) and 23.7% in the 1988/99 cohort (142/599). Only the number of sexual partners was a significant risk factor for HPV infection (odds ratios 22.687 and 6.124 for more than five versus one partner 84 cohort,/84 and 1988/89 cohorts, respectively) in multivariate analysis. HPV16 positive-women were significantly more likely to have abnormal Pap smears of any degree than HPV16-negative women (22.0% versus 3.61%, p < 0.0001 for the 1983/84 cohort and 9.09% versus 2.52%, p = 0.0482 for the 1988/89 cohort). CIN3 was diagnosed in six women 84 cohort,/84 cohort and two in the 1988/89 cohort. All women with CIN3 tested positive for HC2-HR and all six CIN3 cases 84 cohort,/84 cohort tested positive for HPV16. In the 1988/89 cohort, the rate of HPV16 infection was significantly lower in vaccinated than non-vaccinated women (1.59% versus 8.88%; p = 0.003).ConclusionsHR-HPV infection was highly prevalent in both cohorts and associated with an increased risk of abnormal Pap smears and biopsy proven CIN2+. HPV16 infection was associated with a high risk of clinically relevant lesions. HPV vaccination significantly decreased the risk of HPV16 infection.

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Prevalence of Human Papillomavirus Infection in Women in Portugal

Abstract: This is the first population-based study to quantify and describe cervical HPV infection in mainland Portugal. This study provides baseline data for future assessment of the impact of HPV vaccination programs.

Cited by 43 publications

References 24 publications

A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

Distribution of HPV Genotype in Invasive Cervical Carcinoma and Cervical Intraepithelial Neoplasia in Zhejiang Province, Southeast China: Establishing the Baseline for Surveillance

Prevalence of high-risk HPV types and associated genital diseases in women born in 1988/89 or 1983/84 – results of WOLVES, a population-based epidemiological study in Wolfsburg, Germany

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