Prevalence of human papillomavirus types 6, 11, 16, 18, 31, and 33 in a cohort of Greek women

Panotopoulou, Efstathia; Tserkezoglou, Aliki; Kouvousi, Maria; Tsiaousi, I.; Chatzieleftheriou, George; Daskalopoulou, Dimitra; Magiakos, G.

doi:10.1002/jmv.21025

Cited by 20 publications

(22 citation statements)

References 45 publications

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“…HPV16 together with HPV18 are known to be responsible for approximately 70% of the cervical cancer cases worldwide [6, 8, 9]. The prevalence of HPV18 has been reported in other studies, ranging between 1.8% and 16.3% [20, 21, 23, 27]. In agreement with the aforementioned studies, the prevalence of HPV18 in the present study was 4.1%.…”

Section: Discussionsupporting

confidence: 91%

“…Our study showed that at least 22.8% of women were infected with two or more HPV genotypes, in accordance with other studies reporting a prevalence of multiple infections in 11% to 50% of cases [21, 23, 34]. The clinical significance of co-infection with multiple HPV genotypes remains uncertain, with some reports showing that the clearance rate in immunocompetent women is not dependent on the number of genotypes involved in the infection [35].…”

Section: Discussionsupporting

confidence: 89%

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HPV prevalence and type distribution in Cypriot women with cervical cytological abnormalities

2017

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BackgroundHuman papillomavirus (HPV) is the most common sexually transmitted agent, and it can cause cervical lesions and cancer in females. Currently, information regarding the prevalence of HPV in Cyprus is lacking. The aim of this study was to evaluate the HPV type-specific prevalence in 596 women, aged 19–65 years, with cytological abnormalities. Additionally, in a subset of 348 women for whom cytology results of the Pap test were available, the association between HPV infection and cervical disease was investigated.MethodsHPV detection and typing was carried out using PCR and restriction fragment length polymorphism analysis, respectively.ResultsOverall, the HPV prevalence was 72.8%, and it was shown to be age dependent, with a decreasing prevalence until the age of 45 years (p = 0.0018, χ2). Two hundred and fifty-eight women (59.4%) were infected with high-risk HPV, 151 (34.8%) with low-risk HPV, and 25 (5.8%) with HPV types of unknown risk. The most common high-risk HPV type was HPV16 (17.7%), followed by HPV31 (12.9%), HPV58 (7.1%), HPV68 (4.6%), HPV18 (4.1%), and HPV56 (3.7%). Among the women for whom cytology results were available, 268 (77%) were HPV positive, with a sample distribution as follows: 188 (74%) had atypical squamous cells of undetermined significance (ASCUS), 61 (85.9%) had low-grade squamous intraepithelial lesion (L-SIL), and 19 (82.6%) had high-grade squamous intraepithelial lesion (H-SIL). HPV16 was the most common type among women affected by L-SIL (19.7%) and H-SIL (15.8%), with HPV31 being the most common type in women affected by ASCUS (16.5%).ConclusionsThe present study provides the first epidemiological data related to HPV prevalence and type distribution in Cypriot women with cytological abnormalities.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

HPV prevalence and type distribution in Cypriot women with cervical cytological abnormalities

2017

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“…This rate is slightly higher compared with previous results of our group in smaller samples (Agorastos et al, 2004(Agorastos et al, , 2005 and lower than these of other Greek studies in much smaller, selected populations (Agorastos et al, 1995;Kroupis et al, 2007;Panotopoulou et al, 2007).…”

Section: Discussioncontrasting

confidence: 82%

Prevalence and distribution of high-risk human papillomavirus in Greece

Αγοραστός

Lambropoulos²,

Sotiriadis³

et al. 2009

European Journal of Cancer Prevention

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As knowledge of regional human papillomavirus (HPV) type distribution is essential for the optimization of prevention strategies, this study was carried out to explore the prevalence and type distribution of high-risk HPV in a screening population across Greece. Cervical samples were collected by local physicians and nurses in hospitals and health centers across the country from 4139 women attending for cervical cancer screening. High-risk HPV-DNA was detected by using Hybrid Capture-2 (HC2) and positive samples with adequate cellular content were further typed by restriction fragment length polymorphism-polymerase chain reaction. Almost six percent (5.9%) of women tested positive in HC2. The most common type was HPV16 (1.4% in the whole sample and 32.4% of the typed samples), followed by HPV53 (0.6 and 14.0%, respectively), HPV31 (0.6 and 12.9%, respectively), HPV35 (0.5 and 12.3%, respectively), HPV51 (0.4 and 7.8%, respectively), HPV18 (0.3 and 7.3%, respectively) and 22 more types. Almost 15% of the typed samples showed a coinfection with two HPV types and 2.1% with three types. There was a bimodal distribution by age, with the highest peak in women 20-29 years old and a lower peak in women 50-59 years old. Apart from the types originally included in HC2 cocktail, PCR analysis identified 15 more types (HPV6, HPV11, HPV34, HPV37, HPV38, HPV42, HPV53, HPV54, HPV55, HPV61, HPV62, HPV66, HPV73, HPV82, HPV83). Eleven percent of HC2-positive results arose from single-type infections with HPV53 (10%) and HPV66 (1%), which are potentially high-risk types. In conclusion, HPV16 is the most common type in the largest Greek screening sample used to date and, together with its related types, accounts for more than half of high-risk HPV infections. Approximately 10% of positive HC2 results arise from HPV53, which is not normally detected by the test, but may be clinically significant.

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“…In Spain HPV 18 does not appear as common as in this current study [Cobo et al, 2009]. In contrast, HPV 18 was detected in a Greek study in a large proportion of women with cytological abnormalities [Panotopoulou et al, 2007]. Other studies showed that HPV 18 can be under-represented and other high-risk HPV genotypes over-represented in low-grade lesions as well as high-grade lesions in comparison to invasive cervical cancer [Smith et al, 2007].…”

Section: Discussioncontrasting

confidence: 72%

Human papillomavirus infection among women with cytological abnormalities in Switzerland investigated by an automated linear array genotyping test

Dobec¹,

Bannwart²,

Kilgus³

et al. 2011

Journal of Medical Virology

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Limited data are available describing human papillomavirus (HPV) genotype distribution among females with cytological abnormalities in Switzerland. Cervical cell specimens obtained from 5,318 women were screened routinely by liquid-based Pap smear. All specimens with cellular abnormalities were analyzed subsequently for HPV DNA by the Linear Array HPV genotyping test. Cellular abnormalities were found in 202 (3.8%) specimens, of which 150 (74.3%) were positive for high-risk (HR) HPV. HR-HPV was detected in 20 (60.6%; 95% CI, 43.7-75.4%) of 33 specimens with atypical squamous cells of undetermined significance compared to 98 (72.1%; 95% CI, 64-78.9%) of 136 low-grade squamous intraepithelial lesions and 32 (97%; 95% CI, 83.4-99.9%) of 33 high-grade squamous intraepithelial lesions. The cumulative prevalence of HR-HPV other than HPV 16 and 18 was significantly higher than HPV 16 and/or 18 lesions with atypical squamous cells and low-grade lesions and was comparable in high-grade squamous intraepithelial lesions. The most common HR-HPV genotypes were HPV 16 (15.2%), HPV 31 (12.1%), HPV 58 (12.1%), HPV 51 (9.1%), and HPV 59 (9.1%) in women with atypical squamous cells, HPV 16 (25%), HPV 51 (16.9%), HPV 52 (11.8%), HPV 31 (9.6%), and HPV 56 (8.1%) in women with low-grade lesions (LSIL) and HPV 16 (57.6%), HPV 18 (18.2%), HPV 31 (15.2%), HPV 52 (12.1%), and HPV 58 (6.1%) in women with high-grade lesions (HSIL).

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Prevalence of human papillomavirus types 6, 11, 16, 18, 31, and 33 in a cohort of Greek women

Cited by 20 publications

References 45 publications

HPV prevalence and type distribution in Cypriot women with cervical cytological abnormalities

HPV prevalence and type distribution in Cypriot women with cervical cytological abnormalities

Prevalence and distribution of high-risk human papillomavirus in Greece

Human papillomavirus infection among women with cytological abnormalities in Switzerland investigated by an automated linear array genotyping test

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