Prevalence of Human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil

Morais, Márcia P. E.; Gato, Cynara Melo; Maciel, Lucinei Alves; Lalwani, Pritesh; Costa, Cristóvão Alves da; Lalwani, Jaila Dias Borges

doi:10.1590/s1678-9946201759080

Cited by 25 publications

(27 citation statements)

References 24 publications

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“…In Japan, the adjusted overall prevalence rates were estimated to be 660 per 100,000 and 1020 per 100,000 in men and women, respectively . The prevalence in the United States, France, Brazil, and Peru were 21.9 per 100,000, 15 per 100,000, 24.7 per 100,000, and 915 per 100,000, respectively, while the prevalence in the Netherlands was 0.85 per 100,000 …”

Section: Discussionmentioning

confidence: 99%

The prevalence of human T‐cell leukemia virus in blood donors in China

Huang

et al. 2019

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BACKGROUND China has not yet incorporated routine human T‐lymphotropic virus (HTLV)‐1/2 blood donor screening, even though HTLV has been reported in the southeastern coastal region. This study was conducted to investigate the prevalence of HTLV in five major regions across of China. METHODS From January 2016 to December 2017, blood samples were collected in 20 blood centers located in different regions of China. These samples were screened for HTLV‐1/2 antibodies using enzyme‐linked immunosorbent assay (ELISA). If the test samples were reactive, the samples were confirmed with a western blot (WB) assay. If the results of WB were indeterminate, the donor was interviewed after a minimum lapse of 8 weeks. All follow‐up samples from donors were tested for anti–HTLV‐1/2 with ELISA and WB. RESULTS There were 875,453 donor samples tested for anti–HTLV‐1/2 by ELISA. In all, 365 samples tested negative, 22 samples tested positive by WB, and 14 samples with HTLV status undetermined due to being lost to follow‐up. The prevalences were 11.09, 5.96, 3.16, 2.88 and 0.98 per 100,000 in Xiamen, Changsha, Beijing, Shenzhen, and Nanjing blood center, respectively. The prevalences were 0 per 100,000 for all 15 other blood centers. There was significant differences in the prevalence of HTLV in different regions of China (p = 0.0011). CONCLUSION In China, HTLV‐1 confirmed positive donors are mainly from southeastern coastal areas. It may be necessary to conduct HTLV screening in these areas to reduce the risk of transfusion‐transmitted HTLV.

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Section: Discussionmentioning

confidence: 99%

The prevalence of human T‐cell leukemia virus in blood donors in China

Huang

et al. 2019

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“…It is important to note that in Brazil, the public health system offers free universal treatment for individuals infected by the HIV. Another limitation is that qPCR tests were only carried out in individuals who tested positive to HTLV-1/2 screening using ELISA, so recent infections with a small concentration of anti-HTLV-1/2 antibodies may not have been detected, thus resulting in false-negative test result (Morais et al, 2017). The small number of HIV/HTLV coinfection individuals limits statistical analysis and the ability to identify factors associated with viral infections; thus, future studies with a larger sample size are necessary to research the real factors associated with HTLV infection in the PLWHA population in the State of Pará.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Molecular Epidemiology of Human T-Lymphotropic Virus (HTLV) Infection in People Living With HIV/AIDS in the Pará State, Amazon Region of Brazil

et al. 2020

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“… Most of the reports were performed in Brazil, Peru and Jamaica; all of them are considered endemic regions , , . …”

Section: Methodsmentioning

confidence: 99%

Human T‐Cell Lymphotropic Virus Type 1 and associated diseases in Latin America

Eusebio‐Ponce

Candel

Anguita

2019

Tropical Med Int Health

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This narrative review, which is based on a systematic literature search following the PRISMA guidelines, provides a general overview of Human T-cell Lymphotropic Virus type 1 (HTLV-1) and associated diseases: Adult T-cell Leukaemia-Lymphoma (ATLL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in Latin America, focusing on epidemiology and prevention. Using the published information on HTLV-1, ATLL and HAM/TSP prevalence, we present comprehensive and accurate maps and tables, and developed an algorithm to assist in the prevention of HTLV-1 transmission through breastfeeding while considering socio-economic status. Latin America is an interesting scenario to study HTLV-1 because of the diverse origin of its population. Apart from the expected high prevalence in inhabitants of African ancestry, the presence of endemic foci affecting indigenous populations is particularly striking. ATLL prevention is the biggest challenge in this field. Most ATLL cases are transmitted through breastfeeding; thus, prevention methods to avoid ATLL in endemic countries have to be focused on this. In view of the high inequality in most Latin American countries, reduction in breastfeeding duration, freezing/ thawing and pasteurisation of breastmilk can be suitable interventions in poor settings, considering that avoiding the risk of malnutrition and infant mortality must be the priority.

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Prevalence of Human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil

Cited by 25 publications

References 24 publications

The prevalence of human T‐cell leukemia virus in blood donors in China

The prevalence of human T‐cell leukemia virus in blood donors in China

Prevalence and Molecular Epidemiology of Human T-Lymphotropic Virus (HTLV) Infection in People Living With HIV/AIDS in the Pará State, Amazon Region of Brazil

Human T‐Cell Lymphotropic Virus Type 1 and associated diseases in Latin America

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