Prevalence of hyperhomocysteinaemia, activated protein C resistance and prothrombin gene mutation in inflammatory bowel disease

Mahmood, Asif; Needham, Jane; Prosser, Jeanne; Mainwaring, Jason; Trebble, Tim; Mahy, Gillian

doi:10.1097/00042737-200507000-00008

Cited by 38 publications

(23 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were obtained by Roblin et al who detected a 55.6% prevalence of hyperhomocysteinemia in patients with IBD [22]. This higher prevalence varied among the patient groups evaluated and the mean values were usually higher compared with healthy controls [23,24].…”

Section: Discussionsupporting

confidence: 87%

Increased Folate Intake with No Changes in Serum Homocysteine and Decreased Levels of C-Reactive Protein in Patients with Inflammatory Bowel Diseases

et al. 2008

View full text Add to dashboard Cite

In order to increase dietary folic acid intake and to improve nutritional status regarding folate by controlling homocysteine concentrations, ten patients with inflammatory bowel diseases (Crohn's disease in the colon and ulcerative colitis) received individualized nutritional guidance and were followed up as outpatients for 2 months. The following procedures were performed at the beginning of the study (T0), after 1 month (T1) and at the end of the study (T2): collection of anthropometric data (weight and height), dietary data (24 h diet recall), and blood under fasting condition for the determination of serum folic acid, homocysteine, C-reactive protein, and vitamin B12. Plasma folic acid deficiency was not detected but hyperhomocysteinemia was present in six individuals and C-reactive protein (CRP) was increased (>0.5 mg/dl) in seven patients. After the patients were instructed there was a significant increase in vitamin B6 intake (about 35%) and in folate intake (49.6%). Mean plasma levels of folic acid, homocysteine, and vitamin B12 did not change, but there was a significant decrease of CRP at T1, 0.36 mg dl(-1) on average (P = 0.01), which was maintained at T2. We conclude that the increased folate intake reported by this group of patients was not reflected in improved serum concentrations of folic acid and homocysteine. However, the guidelines for the patients probably induced them to choose a more adequate diet, providing nutrients that help control the inflammatory process.

show abstract

Section: Discussionsupporting

confidence: 87%

Increased Folate Intake with No Changes in Serum Homocysteine and Decreased Levels of C-Reactive Protein in Patients with Inflammatory Bowel Diseases

et al. 2008

View full text Add to dashboard Cite

show abstract

“…It is present in approximately 2% of Caucasians, leads to greater prothrombin plasma levels (heterozygous carriers have about 30% higher PT levels than healthy controls), and increases the risk of venous thrombosis about threefold [38] . However, no definite association between this gene mutation and IBD has been detected in several studies [30,[33][34][35]39] . Presence of this mutation is found at a similar prevalence in IBD patients as well as in IBD patients with thrombosis [27,[32][33] .…”

Section: G20210a Prothrombin Gene Mutationmentioning

confidence: 98%

Thrombosis and inflammatory bowel disease-the role of genetic risk factors

Tsiolakidou

Koutroubakis²

2008

WJG

View full text Add to dashboard Cite

show abstract

“…Patients with UC and CD are at risk of developing micronutrient deficiencies including folate, iron, vitamin D, and so forth, and require close nutritional monitoring (40). Many studies have found the elevated concentration of homocysteine in plasma and colonic mucosa of patients suffering from IBD (41). The homocysteine levels may be influenced by nutritional (folate, B 12 , and B 6 ), genetic and pharmacological factor in IBD.…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

Folate status in various pathophysiological conditions

2008

View full text Add to dashboard Cite

SummaryFolate is the generic term for compounds that have vitamin activity similar to that of pteroylglutamic acid. Folate acts as a coenzyme in several single carbon transfers involved in biosynthesis of purine nucleotides and deoxythymidylic acid essential for DNA and RNA synthesis. In addition, folate provides onecarbon unit for methylation of a wide variety of biological substances including DNA, proteins, phospholipids, and neurotransmitters, thereby regulating their function. Recent epidemiological-clinical and experimental studies suggest the association of folate deficiency with the risk of various cancers, birth defects, and cardiovascular diseases. Thus, it is important to consider the conditions that are associated with altered folate status and their consequences. The impairment in folate status has been found in number of pathophysiological conditions like inflammatory bowel disease, cancer, alcoholism, pregnancy, neonatal growth, and during administration of some drugs. The recent advances dealing with mechanistic aspects of impaired folate status in these conditions have been discussed in this review. IUBMBIUBMB Life, 60(12): 834-842, 2008

show abstract

Prevalence of hyperhomocysteinaemia, activated protein C resistance and prothrombin gene mutation in inflammatory bowel disease

Cited by 38 publications

References 24 publications

Increased Folate Intake with No Changes in Serum Homocysteine and Decreased Levels of C-Reactive Protein in Patients with Inflammatory Bowel Diseases

Increased Folate Intake with No Changes in Serum Homocysteine and Decreased Levels of C-Reactive Protein in Patients with Inflammatory Bowel Diseases

Thrombosis and inflammatory bowel disease-the role of genetic risk factors

Folate status in various pathophysiological conditions

Contact Info

Product

Resources

About