Prevalence of hyperhomocysteinemia in an elderly population

Janson, Jorge; Galarza, Carlos; Murúa, Alicia; Quintana, Irene; Przygoda, Pablo; Waisman, Gabriel; Cámera, Luis; Kordich, L; Morales, Margarita S.; Mayorga, Luis M.; Cámera, Mario I

doi:10.1016/s0895-7061(01)02165-3

Cited by 24 publications

(12 citation statements)

References 17 publications

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“…Although the prevalence of HHcy in the general population is estimated to be around 5%, it is significantly higher in the elderly [ 5 ], a population in which B-vitamin status is a major contributor to HHcy [ 6 ]. Interestingly, elderly men have been found to have elevated plasma homocysteine compared to women [ 7 ], while AD is more common in women [ 8 ], highlighting that HHcy is only one in a complex array of factors influencing any given individual’s risk of dementia. Nonetheless, the population attributable risk of dementia from raised Hcy is estimated to be between 4 and 31%; in other words, preventing HHcy could prevent somewhere between 1 in 25 to 1 in 3 cases of AD [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…homocysteine compared to women [7], while AD is more common in women [8], highlighting that HHcy is only one in a complex array of factors influencing any given individual's risk of dementia. Nonetheless, the population attributable risk of dementia from raised Hcy is estimated to be between 4 and 31%; in other words, preventing HHcy could prevent somewhere between 1 in 25 to 1 in 3 cases of AD [9].…”

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confidence: 99%

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Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

Braun

Dimayuga

Morganti

et al. 2020

J Neuroinflammation

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Background Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer’s disease (AD) in elderly populations. While dietary supplementation of B-vitamins is a generally effective method to lower homocysteine levels, there is little if any benefit to cognition. In the context of amyloid pathology, dietary-induced HHcy is known to enhance amyloid deposition and certain inflammatory responses. Little is known, however, about whether there is a more specific effect on microglia resulting from combined amyloid and HHcy pathologies. Methods The present study used a knock-in mouse model of amyloidosis, aged to 12 months, given 8 weeks of B-vitamin deficiency-induced HHcy to better understand how microglia are affected in this comorbidity context. Results We found that HHcy-inducing diet increased amyloid plaque burden, altered the neuroinflammatory milieu, and upregulated the expression of multiple damage-associated and “homeostatic” microglial genes. Conclusions Taken together, these data indicate complex effects of comorbid pathologies on microglial function that are not driven solely by increased amyloid burden. Given the highly dynamic nature of microglia, their central role in AD pathology, and the frequent occurrence of various comorbidities in AD patients, it is increasingly important to understand how microglia respond to mixed pathological processes.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

Braun

Dimayuga

Morganti

et al. 2020

J Neuroinflammation

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“…It has been widely accepted that Hcy levels increase with age, and hyperhomocysteinemia is more frequent in the elderly than in other age groups [15]. This research did not assess RIs of Hcy for specific subgroups within the adult population, such as postmenopausal women [24] or individuals older than 65 years [25]. According to the IFCC and CLSI guidelines, the evaluation of Hcy levels for certain conditions would require the stratification of the population into specific subgroups, and therefore the inclusion of at least 120 subjects per each class, as well as the design of appropriate questionnaires to collect more accurate information among participants.…”

Section: Discussionmentioning

confidence: 97%

Reference values of plasma homocysteine in Cuban children and adults

Alvarez

Viera

Buigues³

et al. 2020

Journal of Laboratory Medicine

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ObjectivesHomocysteine (Hcy) is a nonessential amino acid, produced by the demethylation of methionine. High Hcy levels, or hyperhomocysteinemia, have been associated with genetic and multifactorial diseases. Hcy reference values may vary between different populations, as Hcy levels are affected by factors such as sex, age, diet, smoking, and coffee consumption. The estimation reference interval (RI) allows to establish the normal values of this marker in population. At present, these levels are unknown in Cuba. The aim of this work is to estimate the Hcy reference intervals in Cuban children and adults.MethodsTotal Hcy concentration was quantified by high performance liquid chromatography (HPLC) in plasma. Hcy levels were evaluated in samples from 507 healthy individuals (260 children, 247 adults).ResultsRIs were estimated by nonparametric methods. We found significant differences between both age groups, but we did not find significant differences between sexes, within these groups. The established ranges were 2.56–14.55 µM and 3.63–17.19 µM for children and adults, respectively. Also, we observed a weak association between Hcy levels and age in both sex groups.ConclusionsThis is the first study that assesses Hcy reference values in Cuban population. Our results will allow the introduction of Hcy as a biochemical marker in laboratory testing.

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“…Positive association of Hcy with age or alcohol intake have been widely reported 20,25,27 . Though the mechanism underlying this association is vague, it is hypothesized that deficiency in folate, vitamin B12, metabolic changes, poor nutritional absorption and organ function associated with ageing or alcohol intake are possible causes of this anomaly [40][41][42] .…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia and its Relations to Conventional Risk Factors for Cardiovascular Diseases in Adult Nigerians: The REMAH Study.

Chori

Danladi

Inyang

et al. 2020

Preprint

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Background: Evidence linking homocysteine (Hcy) with cardiovascular diseases (CVD) or its risk factors are insufficient in a Sub-Saharan black population. Objective: We set out to evaluate the association between Hcy and hypertension and other CVD risk factors in a population of adult Nigerians. Methods: Data of 156 adults aged 18-70years was accessed from the North Central study site of the REmoving the MAsk on Hypertension (REMAH) study. Homocysteine, blood glucose and lipid profile in whole blood/serum were measured using standard laboratory methods. Hypertension was diagnosed if average of 5 consecutive blood pressure (BP) measurements obtained using a mercury sphygmomanometer was equal to or higher than 140 systolic and/or 90 mmHg diastolic or the individual is on antihypertensive medication. Hyperhomocysteinemia (HHcy) was defined as Hcy>10µmol/L. Results: Of the 156 participants, 72 (43.5%) were hypertensive, of whom 18 had HHcy. Subjects with HHcy were significantly (p<0.05) older (41.5 vs 40.6yrs), had lower HDL-cholesterol (0.6 vs 0.8mmol/L) and higher systolic (145.5 vs 126.0mmHg) and diastolic BP (92.9 vs 79.6mmHg), compared to those without HHcy. Intake of alcohol and a 1yr increase in age were respectively and significantly (p<0.05) associated with a 1.54 and 0.10 µmol/L increase in Hcy. In a multivariable model adjusted for age, sex and body mass index, a 1µmol/L increase in Hcy, was associated with a 1.69 mmHg and 1.34 mmHg increase in systolic and diastolic pressure (p< 0.0001) respectively; and a 0.01mmol/L decrease in HDL-cholesterol (p<0.05). Conclusion: HHcy occurs among hypertensive Nigerians and it is independently associated with age, HDL-cholesterol, systolic and diastolic BP.

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Prevalence of hyperhomocysteinemia in an elderly population

Abstract: The very high prevalence of tHHcy in the elderly population, and the consequent risks associated with it suggest that although there are no trials that effectively prove the benefit of tHcy decrease, nutritional intervention is still justified.

Cited by 24 publications

References 17 publications

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

Reference values of plasma homocysteine in Cuban children and adults

Hyperhomocysteinemia and its Relations to Conventional Risk Factors for Cardiovascular Diseases in Adult Nigerians: The REMAH Study.

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