Prevalence of hyperinsulinaemia among normozoospermic donors at Medfem Clinic, South Africa

Bosman, E.; Esterhuizen, A. D.; Rodrigues, F. A.; Becker, Piet J.; Hoffmann, Willem A.

doi:10.1111/j.1439-0272.2012.01303.x

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…Insulin has an influence on the levels of sex‐hormone‐binding globulin (SHBG) and can contribute to low testosterone levels (Jensen et al ., ; Tsai et al ., ). Men with high insulin levels have a tendency to present with a higher percentage of poorly compacted sperm deoxyribonucleic acid (DNA) and lower pregnancy rates in an IVF programme (Bosman et al ., , ). Certain treatments such as metformin, a modified diet and exercise, can effectively control high insulin levels.…”

Section: Introductionmentioning

confidence: 99%

Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males

Bosman¹,

Esterhuizen²,

Rodrigues³

et al. 2014

Andrologia

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SummaryPrevious reports indicated that hyperinsulinaemic men may exhibit a higher percentage of poorly compacted DNA in their spermatozoa and less success in an IVF programme (Andrologia, 45, 2003, 18; Andrologia, 2014 Andrologia, , doi: 10.1111. The aim of this study was to investigate the effect of metformin (Glucophage ® ) and antioxidant treatment (StaminoGro ® ) on the semen parameters of hyperinsulinaemic men. Nineteen hyperinsulinaemic male patients were treated for 3 months with metformin alone (Group A), and fifteen patients used metformin in combination with the nutritional supplement (Group B). Combined data of the two groups (pre-and post-treatment) differ significantly regarding sperm morphology (P = 0.0003) and CMA 3 (P < 0.0001) values. The improvement in sperm morphology after treatment was similar for the two respective groups (P < 0.05). The morphological normal sperm forms increased from the mean percentage of 3.9 to 5.5% and from 4.2 to 5.5% for Group A and B respectively. Where a combination of metformin and the supplement were used (Group B), the combination treatment proved to be superior in obtaining enhanced chromatin packaging quality although not statistically significant (P = 0.5929) when compared with the metformin (Group A) group. The chromatin packaging quality in Group B improved with 10% while the improvement in Group A was approximately 8.3%. Therefore, infertile hyperinsulinaemic men can benefit from metformin treatment and should be advised on the use of nutritional supplements with antioxidant properties.

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Section: Introductionmentioning

confidence: 99%

Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males

Bosman¹,

Esterhuizen²,

Rodrigues³

et al. 2014

Andrologia

Self Cite

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“…Only two researchers have attempted to investigate the effect of male hyperinsulinemia on IVF outcomes. One study investigated the effect of hyperinsulinaemia on IVF outcomes, and reported that compared to donors with normal insulin levels, donors pregnancy outcomes in the IVF program [ 27 ]. Meanwhile, to investigate the role of insulin in male fertility, the authors did a further study that showed the clinical pregnancy rate in the male normal insulin group was significantly higher than that in the hyperinsulinemia group, suggesting that male hyperinsulinemia had a negative impact on IVF outcomes [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of fasting hyperglycemia in men on pregnancy outcomes of singleton pregnant women with cryo-thawed embryo transfer

Yang,

Tian,

et al. 2023

Eur J Med Res

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Background The relationship of metabolic issues to pregnancy outcomes during assisted reproductive technology (ART) is gaining much attention. Fasting Plasma Glucose (FPG) is one of the most common metabolic indicators. Abnormal FPG not only affects the quality of life of human body, but also has a bearing on reproductive health. However, most attentions are paid on women's physical health and reproductive assessment, the health status of the male partner on pregnancy outcomes during ART treatment is often neglected. This study investigated whether male fasting hyperglycemia (FH, FPG > 6.1 mmol/L) can affect live birth rates (LBR) in singleton intrauterine clinical pregnancy women with cryo-thawed embryo transfer (CET) cycles. Material and methods A retrospective cohort study (370 CET cycles with first singleton clinical intrauterine pregnancy and grouped by male FPG) was conducted to analyze the relationship between male FH and clinical pregnancy outcomes using binary logistic regression; the odds ratios (ORs) and 95% confidence intervals (CIs) were calculated as a measure of relevancy. Live birth rate was the main outcome measure. Results The live birth rate (LBR) was significantly lower [58.6% vs. 81.8%, P = 0.007, adjusted OR 0.635, 95% CI 0.456–0.884] and miscarriage rate (MR) was significantly higher [41.4% vs. 18.2%, P = 0.007, adjusted OR 1.575, 95% CI 1.131–2.195] in the FH group when compared with the Con group. There was no difference in healthy baby rate [88.2% vs. 89.6%, P = 0.058, adjusted OR 2.143, 95% CI 0.974–4.716] or abnormal birth weight rate (23.5% vs. 11.8%, P = 0.238, adjusted OR 2.859, 95% CI 0.777–10.460] between the FH and control group. No birth defects were observed in the present study. Conclusion Male FH is an independent risk factor for lower LBR and higher MR in singleton intrauterine pregnancy women with CET cycles.

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“…El tabaquismo se asocia a aumento de la actividad de la lipasa hepática, IR, dislipemia y aterosclerosis temprana. En los individuos fumadores la producción de espermatozoides es normal, sin embargo, la fragmentación del ADN altera su capacidad de reproducción 119 .…”

Section: ) Factores De Riesgo Cardiovascular E Infertilidad Masculinaunclassified

Trastornos De La Fertilidad en El Hombre Con Diabetes Tipo 1 Y 21

Pomares

Burruchaga²,

Ávila³

et al. 2014

Rev. Soc. Argent. Diabetes

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La diabetes mellitus (DM) es una de las mayores amenazas para la salud pública en las sociedades modernas. Si bien durante varios años se sugirió que la DM no tenía efecto significativo en la función reproductiva masculina, esta visión fue cambiando. La creciente incidencia de la DM a nivel mundial afectará a cada vez más hombres y de menor edad, y por lo tanto podría afectar su potencial reproductivo.

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Prevalence of hyperinsulinaemia among normozoospermic donors at Medfem Clinic, South Africa

Cited by 5 publications

References 38 publications

Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males

Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males

Effects of fasting hyperglycemia in men on pregnancy outcomes of singleton pregnant women with cryo-thawed embryo transfer

Trastornos De La Fertilidad en El Hombre Con Diabetes Tipo 1 Y 21

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