Prevalence of hypertension and associated cardiovascular risk factors among pharmacies customers: an Italian nationwide epidemiological survey

Pinto, Rita Del; Pagliacci, Silvia; Feo, Martina De; Grassi, Davide; Ferri, Claudio; Federfarma,

doi:10.1177/2047487319851301

Cited by 18 publications

(21 citation statements)

References 7 publications

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“…Interestingly, in‐hospital all‐cause mortality relative to the year 2020 did not exceed that of 2019; indeed, the lower number of global deaths in 2020 compared with 2019 was in line with data from the previous 5 years, 8 which might reflect the efficacy of primary and secondary prevention strategies (ie, healthy and active lifestyle, control of major personal and environmental risk factors) 9,10 …”

Section: Introductionsupporting

confidence: 62%

“…Although the authors cannot infer the causal determinants of the observed findings, it is possible that changes in hospitalization patterns might explain the subsequent increase in cardiovascular deaths. Besides unmeasured factors and host‐specific features, 9,11 including forced lifestyle changes and related effects, it is possible that late hospital presentations and consequent greater disease severity affected eligibility and outcome of cardiovascular procedures, thus justifying the disproportion in cardiovascular deaths during the national lockdown period.…”

Section: Introductionmentioning

confidence: 99%

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Increased cardiovascular death rates in a COVID‐19 low prevalence area

Pinto

Ferri

Mammarella

et al. 2020

J of Clinical Hypertension

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The spread of COVID-19 pandemic was not homogeneous in Italy, with Northern regions bearing the greatest burden of the disease. In the Abruzzo region, in Central Italy, the province of L'Aquila is the closest to Rome, where the first two imported SARS-CoV-2positive cases have been detected as of January 29, 2020. With a population of 303 239 individuals and a total of 123 COVID-19 cases (40.6/100 000) as of March 31, 2020, the area was among the less affected in Italy (Figure S1, panel A). Specifically, no cases were recorded in the province of L'Aquila before March 3, 2020. A total of 6 patients tested positive for SARS-CoV-2 in the same area as of March 11, 2020 (15.8% of total regional cases [n.38]). As of March 31, 2020, 8.8% (N = 123) of total cumulative cases in the region (N = 1401) was from the province of L'Aquila. Preliminary evidence indicates a reduction in hospital admissions for acute coronary syndromes following the COVID-19 outbreak in Northern Italy. 1 In parallel, a decrease in coronary revascularization procedures in association with the pandemic has been described in Southern Italy. 2 Herein, the authors aimed at assessing whether the even marginal COVID-19 burden in the area of L'Aquila had an impact on cardiovascular hospitalizations and outcomes.

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Section: Introductionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Increased cardiovascular death rates in a COVID‐19 low prevalence area

Pinto

Ferri

Mammarella

et al. 2020

J of Clinical Hypertension

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“…Abbasso la Pressione! (May 17-20, 2018) was a 4-days, nationwide, cross-sectional epidemiological Italian survey co-sponsored by the Italian Society of Hypertension (SIIA) in collaboration with the National Federation of Italian Pharmacies (Federfarma) following the World Hypertension Day in 2018 [13]. It involved 3956 pharmacies (21% of total) throughout the national territory with the aim of estimating prevalence and awareness of modifiable/non-modifiable cardiovascular risk factors, with particular focus on hypertension, among self-presented adult customers (≥ 18 years) who consented to participate.…”

Section: Data Sourcementioning

confidence: 99%

Real-World Hypertension Prevalence, Awareness, Treatment, and Control in Adult Diabetic Individuals: An Italian Nationwide Epidemiological Survey

Feo

Pinto²,

Pagliacci

et al. 2021

High Blood Press Cardiovasc Prev

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Introduction Hypertesion is the leading cause of morbidity and mortality, worldwide, and its prevalence has been increasing in several countries, including Italy. Aims To assess hypertension prevalence, awareness, treatment, and control in a real-world sample of adults with self-reported diabetes compared with nondiabetic individuals. Methods Following the 2018 World Hypertension Day, a nationwide, cross-sectional epidemiological survey on cardiovascular risk factors ("Abbasso la Pressione!") in 3956 Italian pharmacies enrolled 47217 self-presenting volunteers (≥ 18 years). Participants underwent standardized blood pressure (BP) measurements and answered a questionnaire on cardiovascular risk factors and lifestyle habits. Questions included if they had an established diagnosis of diabetes, hypertension or were on a BP medication. Hypertension prevalence was defined as systolic BP ≥ 140 and/or diastolic BP ≥ 90 mmHg. A double definition for hypertension control based on the recent European and US guidelines on hypertension was applied. Results Diabetic individuals (N = 5695, 12%) had higher rates of hypertension prevalence (80% vs. 54.7%, p < 0.001), awareness (85.6% vs 77.3%, p < 0.001) and treatment (85.8% vs. 76.7%, p < 0.001), but lower hypertension control rates (36.1% vs. 39.6% according to the 2018 European guidelines, p < 0.001; 25.4% vs 30.8% according to the 2017 US guidelines, p < 0.001) than nondiabetics. Diabetic participants tended to be older, sedentary, overweight/obese, dyslipidemic men, with higher 10-years cardiovascular risk than nondiabetics (p < 0.001). Uncontrolled hypertension was associated with male gender, diabetes, body mass index, unhealthy lifestyle habits, and older age. Conclusions Elevated hypertension awareness and treatment rates in diabetic adults do not translate into adequate BP control in the real world. Concomitant unfavorable metabolic features and unhealthy lifestyle habits might contribute to this observation.

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“…On the other side, the awareness and the appropriate management of global cardiovascular risk, namely through blood pressure (BP) control, are of paramount importance against disease progression. In fact, although the prevalence of hypertension in Fabry disease was reported not being dissimilar to the general population [2,9], with in some cases a tendency to hypotension attributable to inappropriate vascular control due to autonomic impairment [10], effective BP control is a requisite for outcome improvement in the affected individuals with hypertension.…”

Section: Introductionmentioning

confidence: 99%

The role of Immunity in Fabry Disease and Hypertension: A Review of a Novel Common Pathway

Pinto

Ferri

2020

High Blood Press Cardiovasc Prev

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Fabry disease is a progressive, X-linked inherited lysosomal storage disorder where accumulation of glycosphingolipids increases the risk for early cardiovascular complications, including heart failure, stroke, and end stage renal disease. Besides disease-specific therapy, blood pressure (BP) control is of central importance in Fabry disease to reduce disease progression and improve prognosis. Both Fabry disease and hypertension are characterized by the activation of the innate component of the immune system, with Toll-like receptor 4 (TLR4) as a common trigger to the inflammatory cascade. The renin-angiotensin system (RAS) participates in the establishment of low-grade chronic inflammation and redox unbalance that contribute to organ damage in the long term. Besides exploiting the anti-inflammatory effects of RAS blockade and enzyme replacement therapy, targeted therapies acting on the immune system represent an appealing field of research in these conditions. The aim of this narrative review is to examine the issue of hypertension in the setting of Fabry disease, focusing on the possible determinants of their reciprocal relationship, as well as on the related clinical and therapeutic implications.

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Prevalence of hypertension and associated cardiovascular risk factors among pharmacies customers: an Italian nationwide epidemiological survey

Cited by 18 publications

References 7 publications

Increased cardiovascular death rates in a COVID‐19 low prevalence area

Increased cardiovascular death rates in a COVID‐19 low prevalence area

Real-World Hypertension Prevalence, Awareness, Treatment, and Control in Adult Diabetic Individuals: An Italian Nationwide Epidemiological Survey

The role of Immunity in Fabry Disease and Hypertension: A Review of a Novel Common Pathway

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