Prevalence of Hypertension and Its Associated Risk Factors among 34,111 HAART Naïve HIV-Infected Adults in Dar es Salaam, Tanzania

Njelekela, Marina; Muhihi, Alfa; Aveika, Akum; Spiegelman, Donna; Hawkins, Claudia; Armstrong, Catharina; Liu, Enju; Okuma, James; Chalamila, Guerino; Kaaya, Sylvia; Mugusi, Ferdinand; Fawzi, Wafaie W.

doi:10.1155/2016/5958382

Cited by 36 publications

(38 citation statements)

References 48 publications

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“…This observation corroborates with previous studies of Lichtenstein et al (2010), PefuraYone et al (2011), Ekali et al (2013), Muhammad et al (2013) and Njelekela et al (2016), which revealed a higher incidence of hypertension in patients on cART. Contrarily, the findings of other studies of Agrawal et al (2015) indicated no disparity in the prevalence of hypertension between patients on cART and cARTnaïve patients.…”

Section: Resultssupporting

confidence: 93%

Hypertension and Related Risk Factors Among Clients on Combined Antiretroviral Therapy in Nigeria

Bello

Ojieabu

2018

Bangla Pharma J

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Hypertension is a major challenge in human immunodeficiency virus (HIV) infected people globally. A prospective, cross-sectional study comprising two hundred and eighteen HIV-infected patients was conducted in Antiretroviral Therapy Clinic of General Hospital, Offa between November 2015 and December, 2016. Patients' blood pressure was evaluated using Omron automated blood pressure monitor following standard procedures. Dual weight and height balance was utilized to measure the weight and height of the subjects. Hypertension incidence among patients receiving combined antiretroviral therapy (cART) was 34%, while those that were yet to start cART was 9.6 %. In HIVinfected women on cART, occurrence of hypertension was high (75.5%) as compared to men (24.5%). The hypertension pervasiveness in HIV-infected patients on cART was 75.5% in women and 24.5% in men. Risk factors that were markedly linked with hypertension among patients on cART include body mass index (OR: 3.29,95% CI:1.21-2.27; p< 0.050), sedentary lifestyle (OR: 1.63, 95% CI:1.20-5.38; p < 0.043), age (OR: 2.17, 95% CI: 1.22-2.33; p< 0.004) and gender (OR: 1.63, 95% CI: 0.85-2.41; p < 0.037). Patients on cART were found to have higher hypertension prevalence than cART-naive. The cART, however, is not a risk factor for hypertension.

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Section: Resultssupporting

confidence: 93%

Hypertension and Related Risk Factors Among Clients on Combined Antiretroviral Therapy in Nigeria

Bello

Ojieabu

2018

Bangla Pharma J

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“…The hypertension occurrence was considerably greater in patients on cART as compared to cART-naïve patients. This observation corroborates with previous studies of Lichtenstein et al [15], Pefura Yone et al [16], Ekali et al [17], Muhammad et al [11] and Njelekela et al [18], which revealed a higher incidence of hypertension in patients on cART. Contrarily, the findings of other studies of Agrawal et al [19] indicated no disparity in the prevalence of hypertension between patients on cART and cARTnaïve patients.…”

Section: Discussionsupporting

confidence: 93%

Hypertension and Related Risk Factors among Clients on Combined Antiretroviral Therapy in Nigeria

Bello¹,

Ojieabu²

2017

J Appl Pharm

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The hypertension incidence is a major challenge in human immunodeficiency virus (HIV) infected people globally. A prospective, cross-sectional study comprising two hundred and eighteen HIV-infected patients was conducted in Antiretroviral Therapy Clinic of General Hospital, Offa between November 2015 and December 2016. Patients' blood pressure was evaluated using Omron automated blood pressure monitor following standard procedures. Dual weight and height balance was utilized to measure the weights and heights of the subjects. Hypertension incidence among patients receiving combined antiretroviral therapy (cART) was 34%, while those that were yet to start cART was 9.6%. In HIV-infected women on cART, the occurrence of hypertension was high (75.5%) as compared with men (24.5%). The hypertension pervasiveness in HIV-infected patients on cART was 75.5% in women and 24.5% in men. Risk factors that were markedly linked with hypertension among patients on cART include body mass index (OR: 3.29, 95% CI: 1.21-2.27; p<0.050), sedentary lifestyle (OR: 1.63, 95% CI: 1.20-5.38; p<0.043), age (OR: 2.17, 95% CI: 1.22-2.33; p<0.004) and gender (OR: 1.63, 95% CI: 0.85-2.41; p<0.037). Patients on cART were found to have higher hypertension prevalence than cART-naive. The cART, however, is not a risk factor for hypertension.

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“…Abacavir did not elevate the risk of hypertension, compared to non-abacavir ART, and only elevated the risk among men and older adults who visited tertiary hospitals in urban areas. Old age 24 25 and being male 25 were similar risk factors of hypertension among PLWH in other studies. Nevertheless, while financial status or accessibility to healthcare was not considered in the model, this study found that PLWH who visit institutions with specialty doctors in urban areas were more prone to being diagnosed with hypertension.…”

Section: Discussionsupporting

confidence: 78%

Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study

et al. 2018

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PurposeA high risk of cardiovascular disease (CVD) is reported for HIV-infected individuals. While a link between abacavir and CVD risk is suggested, an association between abacavir and hypertension remains unclear. This study evaluated hypertension risk with abacavir use in comparison to non-abacavir antiretroviral treatment (ART).Materials and MethodsFrom a nationwide cohort of HIV-infected individuals on their initial ART, 6493 who were free of hypertension at baseline were analyzed. The use of ART was treated as a time-varying covariate measured as a daily unit. Incidence rate of hypertension was calculated, and Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) with 95% confidence interval (CI) of incident hypertension overall and among subgroups.ResultsFrom the 6493 participants, 24072 person-years (PY) of follow-up were contributed during 2008–2016. The incidence rates of hypertension were 4.6 and 3.6 per 100 PY for abacavir and non-abacavir ART users, respectively. The population attributable fraction of abacavir use on hypertension was 12%. Abacavir exposure did not elevate the risk of hypertension among overall study population [HR, 1.2 (95% CI, 1.0–1.4), p=0.061]. However, those with poor ART adherence, defined as a medication possession ratio <50% [HR, 1.9 (95% CI, 1.5–2.4), p<0.0001] or requiring prophylactic antibiotics [HR, 1.2 (95% CI, 1.0–1.3), p=0.023], were at risk of hypertension induced by abacavir, as were men, individuals aged ≥40 years, and patients visiting tertiary hospitals in urban areas.ConclusionWhen present, poor ART adherence, requiring prophylactic antibiotics, male sex, and older age may warrant additional concern for hypertension in patients treated with abacavir.

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Prevalence of Hypertension and Its Associated Risk Factors among 34,111 HAART Naïve HIV-Infected Adults in Dar es Salaam, Tanzania

Cited by 36 publications

References 48 publications

Hypertension and Related Risk Factors Among Clients on Combined Antiretroviral Therapy in Nigeria

Hypertension and Related Risk Factors Among Clients on Combined Antiretroviral Therapy in Nigeria

Hypertension and Related Risk Factors among Clients on Combined Antiretroviral Therapy in Nigeria

Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study

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