Prevalence of Hypertension in HIV-Positive Patients on Highly Active Retroviral Therapy (HAART) Compared with HAART-Na�ve and HIV-Negative Controls: Results from a Norwegian Study of 721 Patients

Bergersen, Bente Magny; Sandvik, Leiv; Dunlop, Oona; Birkeland, Kåre I.; Bruun, Johan N.

doi:10.1007/s10096-003-1034-z

Cited by 140 publications

(167 citation statements)

References 26 publications

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“…This prevalence is comparable with the results of other cohorts of PLHIV who had 2% diabetes in Senegal and Norway [5] [6].…”

Section: Clinical Aspectssupporting

confidence: 89%

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Prevalence of Hypertension and Associated Factors in Patients Living with HIV Followed at the Ambulatory Treatment Center (CTA) of Fann National University Hospital in Dakar

Gueye¹,

Kà²,

Tall³

et al. 2017

Health

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Introduction: The efficacy of antiretroviral therapy in people living with HIV (PLHIV) has been associated with an important increase in metabolic disorders, such as hypertension (HTA). This work allowed us to estimate the prevalence of hypertension in PLHIV and to describe associated factors. Methods: A retrospective, descriptive and analytical study was carried out based on the records of people living with HIV followed at the Ambulatory Treatment Center (CTA), from January 1 st 1998 to 31 st , December 2014. The WHO criteria were used to diagnose hypertension. Data entry was performed using ESOPE software and data analysis was done using Epi Info software version 3.5.3. A multiple logistic regression was used to identify the risk factors associated with hypertension. Results: During the study period, 3624 patients followed at CTA were included of which 1184 patients (32.7%) had hypertension. The average age was 47. 3 years ±10.5 years, with a sex ratio of 0.7. The most common opportunistic infections at diagnosis were tuberculosis (14.9%) and oral candidiasis (15.3%). The HIV infection was advanced (stage 3 or 4 of WHO classification) for 39% of cases. Overweight and obesity was found in 19.1%. Only 17.6% were treated by protease inhibitors. Higher average age

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“…This prevalence is comparable with the results of other cohorts of PLHIV who had 2% diabetes in Senegal and Norway [5] [6].…”

Section: Clinical Aspectssupporting

confidence: 89%

“…A study conducted by Bergersen et al [5] in Norway highlighted a male predominance in treated patients (81%) or untreated patients 77%. This difference is due to the predominance transmission through homosexual sex relation in these countries, whereas heterosexual transmission is more frequent in Senegal.…”

Section: Epidemiological Aspectsmentioning

confidence: 98%

Prevalence of Hypertension and Associated Factors in Patients Living with HIV Followed at the Ambulatory Treatment Center (CTA) of Fann National University Hospital in Dakar

Gueye¹,

Kà²,

Tall³

et al. 2017

Health

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“…Such conditions affected 13-48% of our subjects, rates similar to those published from other studies of HIV-infected patients. 3,14,15 Our work also demonstrates that many relationships between traditional risk factors and chronic diseases in the general population (e.g., obesity and hypertension) persist for HIV-infected patients. Furthermore, although much has been made of the contribution of antiretroviral therapy toward development of these conditions, our study indicates that the risk conferred by traditional factors is often comparable toand occasionally greater than-that due to antiretroviral therapy.…”

Section: Discussionmentioning

confidence: 52%

Comorbidity-Related Treatment Outcomes among HIV-Infected Adults in the Bronx, NY

et al. 2011

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Aging, HIV infection, and antiretroviral therapy have been associated with increasing rates of chronic comorbidities in patients with HIV. Urban minority populations in particular are affected by both the HIV/AIDS and chronic disease epidemics. Our objectives were to estimate the prevalence of and risk factors for hypertension, dyslipidemia, and diabetes among HIV-infected adults in the Bronx and describe comorbidity-related treatment outcomes. This was a cross-sectional study of 854 HIV-positive adults receiving care at 11 clinics which provide HIV primary care services; clinics were affiliated with a large urban academic medical center. Data on blood pressure (BP), cholesterol, and glycemic control were collected through standardized chart review of outpatient medical records. We found prevalence rates of 26%, 48%, and 13% for hypertension, dyslipidemia, and diabetes, respectively. Older age, obesity, family history, and current protease inhibitor use were consistently associated with comorbidity. Diabetes treatment goals were achieved less often than BP and lipid goals, and concurrent diabetes was a significant predictor for BP and lipid control. In conclusion, major cardiovascular-related comorbidities are prevalent among HIVpositive adults in the Bronx, especially older and obese individuals. Differences exist in comorbidity-related treatment outcomes, especially for patients with concurrent diabetes. Because cardiovascular risk is modifiable, effective treatment of related comorbidities may improve morbidity and mortality in HIV-infected patients.

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“…Coincident with improved survival, patterns of co-morbidity and mortality have changed among HIV-positive patients: cardiovascular disease, hypertension, and diabetes have become prevalent, [9][10][11] and causes of death have shifted from opportunistic infections to end-stage liver and kidney disease and non-HIV-related malignancies (Table 1). [12][13][14] Research also shows that HIV infection directly affects other organ systems, manifesting as chronic conditions including HIV-associated neurocognitive disorder and pulmonary hypertension.…”

Section: Changing Patients: Morbidity Mortality and Agingmentioning

confidence: 99%

An Epidemic in Evolution: The Need for New Models of HIV Care in the Chronic Disease Era

2011

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Since the beginning of the AIDS epidemic, models of HIV care have needed to be invented or modified as the needs of patients and communities evolved. Early in the epidemic, primary care and palliative care predominated; subsequently, the emergence of effective therapy for HIV infection led to further specialization and a focus on increasingly complex antiretroviral therapy as the cornerstone of effective HIV care. Over the past decade, factors including (1) an aging, long-surviving population; (2) multiple co-morbidities; (3) polypharmacy; and (4) the need for chronic disease management have led to a need for further evolution of HIV care models. Moreover, geographic diffusion; persistent disparities in timely HIV diagnosis, treatment access, and outcomes; and the aging of the HIV provider workforce also suggest the importance of reincorporating primary care providers into the spectrum of HIV care in the current era. Although some HIV-dedicated treatment centers offer comprehensive medical services, other models of HIV care potentially exist and should be developed and evaluated. In particular, primary care-and community-based collaborative practices-where HIV experts or specialists are incorporated into existing health centers-are one approach that combines the benefits of HIV-specific expertise and comprehensive primary care using an integrated, patient-centered approach.

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Prevalence of Hypertension in HIV-Positive Patients on Highly Active Retroviral Therapy (HAART) Compared with HAART-Na�ve and HIV-Negative Controls: Results from a Norwegian Study of 721 Patients

Cited by 140 publications

References 26 publications

Prevalence of Hypertension and Associated Factors in Patients Living with HIV Followed at the Ambulatory Treatment Center (CTA) of Fann National University Hospital in Dakar

Prevalence of Hypertension and Associated Factors in Patients Living with HIV Followed at the Ambulatory Treatment Center (CTA) of Fann National University Hospital in Dakar

Comorbidity-Related Treatment Outcomes among HIV-Infected Adults in the Bronx, NY

An Epidemic in Evolution: The Need for New Models of HIV Care in the Chronic Disease Era

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