Prevalence of hypertension mediated organ damage in subjects with high-normal blood pressure without known hypertension as well as cardiovascular and kidney disease

Maloberti, Alessandro; Rebora, Paola; Occhino, Giuseppe; Alloni, M.; Musca, Francesco; Belli, Oriana; Spanò, Francesca; Santambrogio, G.; Occhi, Lucia; Chiara, Benedetta De; Casadei, Francesca; Moreo, Antonella; Valsecchi, Maria Grazia; Giannattasio, Cristina

doi:10.1038/s41371-021-00604-6

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…Another possible explanation for the results is that the study subjects who underwent physical examinations, not all of subjects had hypertension, diabetes, etc. A clinical study by Maloberti et al indicated that there was no difference in the increase of IMT or carotid plaque in the normal group with high blood pressure, and the odds of having arterial stiffness or carotid hypertension mediated organ damage in the high-normal group was not different to the normal group in multivariate analysis ( 23 ). Further studies are needed in individuals with hypertension alone.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Influence of Blood Pressure and Carotid-Femoral Pulse Wave Velocity on Target Organ Damage in Hypertension

Chao

Wang

et al. 2022

Front. Cardiovasc. Med.

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ObjectivesAssessment of target organ damage (TOD) is an important part of the diagnosis and evaluation of hypertension. Carotid-femoral pulse wave velocity (cf-PWV) is considered to be the gold-standard for noninvasive arterial stiffness assessment. This study aims to analyze the risk of TOD in people with different phenotypes of peripheral blood pressure and cf-PWV.MethodsThe study cohort was recruited from December 2017 to September 2021 at Ruijin Hospital in Shanghai. It was divided into 4 groups according to peripheral blood pressure (pBP) and cf-PWV. TOD was assessed as carotid intima-media thickness (CIMT), chronic kidney disease (CKD), urinary albumin-creatinine ratio (ACR), estimated glomerular filtration rate (eGFR) and left ventricular mass index (LVMI).ResultsA total of 1,257 subjects (mean age 53.13 ± 12.65 years, 64.2% males) was recruited. Age, body mass index (BMI) and fasting blood glucose (FBG), as well as peripheral systolic blood pressure (pSBP), peripheral diastolic blood pressure (pDBP), peripheral pulse pressure (pPP) were significantly different in the four groups (P < 0.01). eGFR, ACR, LVMI and CIMT were significantly different among different groups (P < 0.01). The risk of ACR abnormality was significantly higher in the group with elevated pBP (P = 0.005, OR 2.264, 95%CI 1.277–4.016; and in the group with elevated pBP and cf-PWV (P = 0.003, OR 1.482, 95%CI 1.144–1.920), while left ventricular hypertrophy (LVH) was significantly higher in the group with elevated cf-PWV (P = 0.002, OR 1.868, 95%CI 1.249–2.793).ConclusionDifferent profiles based on the status of PBP and cf-PWV associated with different TOD. Individuals with higher pBP have an increased risk of ACR abnormality, while individuals with only cf-PWV elevated have a higher risk of LVH.

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Section: Discussionmentioning

confidence: 99%

Comparison of Influence of Blood Pressure and Carotid-Femoral Pulse Wave Velocity on Target Organ Damage in Hypertension

Chao

Wang

et al. 2022

Front. Cardiovasc. Med.

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“…It is noted that the expected standard-of-practice is that reported PWV measurements are actually the average of two consecutive measurements or the median of three consecutive measurements if the difference between the first two exceeds 0.5 m/s [63]. [340,350,318,341,319,352,321,338,342,345,354,343,160,355,346,323,357,348,358,359,333,360,169,329,361,330,339,362,335,336,363,364] Peripheral arterial vasculature 16 [365, 349, 344, 351, 347, 337, 353, 322, 356, 324-327, 334, 328, 331] Carotid artery 2 [320,125] Aspect of vasculature assessed Arterial stiffness 49 [349, 340, 332, 350, 318, 344, 341, 351, 347, 319, 320, 352, 321, 337, 338, 353, 342, 322, 345, 354, 343, 160, 355, 346, 356, 125, 323, 324, 357, 348, 358, 325-327, 359, 333, 334, 360, 328, 169, 329, 361, 330, 339, 362, 335, 336, 363, 331, 364] Blood pressure 1 [349] Technique SphygmoCor device 12 [340,341,320,352,…”

Section: Analytic Considerationsmentioning

confidence: 99%

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

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Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.

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“…The increasing prevalence of hypertension has been considered an important risk factor for CVDs, especially in developing countries [ 17 ]. Hypertension could increase the risk of negative impacts on various target organs, and this can lead to developing stroke, coronary heart disease, or heart failure [ 18 ]. In addition, hyperuricemia could also affect the progression of hypertension [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Bean and Nut Intake Were Protective Factors for Comorbid Hypertension and Hyperuricemia in Chinese Adults: Results from China Nutrition and Health Surveillance (2015–2017)

Piao,

Li,

Guo

et al. 2024

Nutrients

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This study aimed to describe the prevalence of comorbid hypertension and hyperuricemia (HH) and detected the dietary factors for HH in Chinese adults aged 18 to 64 years. All of the data were collected from the China Nutrition and Health Surveillance 2015–2017, with a stratified, multistage, random sampling method on a national scale. A total of 52,627 adult participants aged 18~64 years from the CNHS 2015–2017 were included in this study. HH was identified as SUA level cut-offs for males and females of 420 μmol/L and 360 μmol/L, respectively, with mean systolic blood pressure ≥140 mmHg and/or mean diastolic blood pressure ≥ 90 mmHg and/or received antihypertensive treatment within two weeks. The differences in HH prevalence between or among the subgroups were compared by the Rao–Scott chi-square test. The correlations between HH and covariates or metabolic factors were detected by a weighted two-level multivariate survey logistic regression. The total weighted sufficient intake ratios of beans and nuts, vegetables, and red meat were 59.1%, 46.6%, and 64.8%, respectively. The weighted prevalence of HH in the total participants was 4.7% (95% CI: 4.3–5.0%). The positive effects of bean and nut on HH were observed. The participants who had sufficient bean and nut intake showed lower risk for HH (for the total participants: OR = 0.734, 95% CI = 0.611–0.881). The prevalence of HH might have been a public health problem, and bean and nut intake might be a protective factor for HH in the Chinese population.

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Prevalence of hypertension mediated organ damage in subjects with high-normal blood pressure without known hypertension as well as cardiovascular and kidney disease

Cited by 7 publications

References 39 publications

Comparison of Influence of Blood Pressure and Carotid-Femoral Pulse Wave Velocity on Target Organ Damage in Hypertension

Comparison of Influence of Blood Pressure and Carotid-Femoral Pulse Wave Velocity on Target Organ Damage in Hypertension

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

Bean and Nut Intake Were Protective Factors for Comorbid Hypertension and Hyperuricemia in Chinese Adults: Results from China Nutrition and Health Surveillance (2015–2017)

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