Prevalence of Hyperthyroidism and Hypothyroidism and its Correlation with Serum Antithyroglobulin among patients in Kirkuk-Iraq ‎

Salih, Sabah M.; Kamel, Wijdan Abdullameer; Abbas, Mohammed Talat; Abass, Kasim Sakran

doi:10.51847/kwvd06aago

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…In Baghdad and Basrah (the two biggest provenances in center and south of Iraq), the distribution of hypothyroidism was found to be 3.2% and 12.5% respectively (3,4). While in Duhok (the provenance in the north of Iraq), hypothyroidism was found to be 1.20% of the studied population and in Kirkuk, there were 22.7 % had hypothyroidism of the study participants (5,6).…”

Section: Introductionmentioning

confidence: 84%

“…Hypothyroidism was represented as a chronic illness of the endocrine system that is associated with insufficient production of thyroid hormones, thyroxine (T4) and triiodothyronine (T3) (1,2). The prevalence of hypothyroidism has been studied in different provinces of Iraq (3)(4)(5)(6). In Baghdad and Basrah (the two biggest provenances in center and south of Iraq), the distribution of hypothyroidism was found to be 3.2% and 12.5% respectively (3,4).…”

Section: Introductionmentioning

confidence: 99%

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Investigating the Effect of Genetic Polymorphisms of Deiodinase Type 2 on Levothyroxine Dose Requirements in Patients with Hypothyroidism

Rasheed,

Al-Metwali,

Al Shamaa

2023

Al-Kindy Col. Med. J

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Background: Hypothyroidism is the most abundant thyroid disorder worldwide. For decades, levothyroxine was the main effective pharmacological treatment for hypothyroidism. A variety of factors can influence levothyroxine dose, such as genetic variations. Studying the impact of genetic polymorphisms on the administration of medications was risen remarkably. Different genetic variations were investigated that might affect levothyroxine dose requirements, especially the deiodinase enzymes. Deiodinase type 2 genetic polymorphisms’ impact on levothyroxine dose was studied in different populations. Objective: To examine the association of the two single nucleotide polymorphism (SNP)s of deiodinase type 2 (rs225013 and rs225014) and levothyroxine dose requirements. Subjects and Methods: A cross-sectional study was conducted at Baghdad Center for Nuclear Medicine and Radiation Therapy located in Baghdad/ Iraq, from March to June 2022. Based on levothyroxine dose, the enrolled patients were divided into two groups: low dose group < 1.7 µg/kg/day and high dose group ≥ 1.7 µg/kg. Then genotyping analysis was done for both groups of the study. Results: The mean age of the participants was 40.35 ± 9.5 years with a mean body mass index of 30.61 ± 5.72 kg/m2. The mean levothyroxine doses in the low- and high-dose groups were 81.67 ± 30.74 µg/day and 161.67 ± 35.19 µg/day, respectively. Significant differences existed in the levels of TSH and TT4 between the study’s groups. Conclusion: This study indicated that the differences in levothyroxine dose, TSH, TT4 and TT3 levels were not associated with the DIO2 rs225013. Similarly, the differences in TSH, TT3 and TT4 levels revealed a non-significant association with DIO2 rs225014 except for levothyroxine dose which was higher in the patients who carried the wild type allele (TT).

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Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Investigating the Effect of Genetic Polymorphisms of Deiodinase Type 2 on Levothyroxine Dose Requirements in Patients with Hypothyroidism

Rasheed,

Al-Metwali,

Al Shamaa

2023

Al-Kindy Col. Med. J

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“…According to SALIH et al's study conducted in Kirkuk [8] , there is a higher incidence of hypothyroidism in (30)(31)(32)(33)(34)(35)(36)(37)(38)(39). Another Diyala study by MOHAMMUD HABASH et al [9] reveals a significant frequency of thyroid illness in people between the ages of 31 and 40.…”

Section: Discussionmentioning

confidence: 99%

Bone and thyroid nexus in thyroid disease patients

Jarjees,

Sarhat

2024

Nat. J. Clin. Orthop.

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Background: Hypothyroidism is the second most prevalent endocrine disease in women, characterized by insufficient production of thyroid hormone by the thyroid gland. Objectives: The present study aims to assess the serum level of osteocalcin, T3, T4, TSH, and thyroid peroxidase in women with hypothyroidism and to investigate the effect of medical therapy on osteocalcin, T3, T4, TSH, and thyroid peroxidase levels in subjects with hypothyroidism. Methods: This study has investigated 180 women (70 women before treatment, 70 after treatment and 40 controls), who's ages range between (15-54) years. Patients were referred to two primary hospitals, Azadi Hospital in Kirkuk City and Kirkuk General Hospital, between September 2023 and December 2023. The participants in this research are categorized into three groups: Before therapy, a group of 70 women with hypothyroidism was diagnosed by medical professionals. The second group consisted of 70 women who had hypothyroidism and had undergone therapy compared to the control group. Serum levels of osteocalcin and thyroid peroxide (TPO), TSH, T3, and T4 were measured. Results: According to the presented data show a decrease in the mean of the serum level of osteocalcin, T3, and T4 in hypothyroidism women before and after treatment compared with the control group (13.4±4.9 versus 19.8±5.1 and 21.5±5.0), (2.49±0.65 versus 6.17±1.40 and 5.65±2.04 ng/ml), (6.85±1.72 versus 14.83±4.21 and 14.86±3.11 ng/ml) respectively. The result was significant (P <0.01) while increasing the mean of TSH and TPO in hypothyroidism before and after treatment compared with the control group (32.78±8.83 versus 4.26±1.77 and 4.48±1.68 ng/ml). Conclusion: It was concluded that the osteocalcin, T3, and T4 decreased in women with hypothyroidism before treatment in comparison with women after treatment and healthy women, while Furthermore increase the mean of TSH and TPO in hypothyroidism before and after treatment compared with the control group.

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The role of advanced glycation end products and oxidative stress in the pathophysiology of thyroid disorders

Raheem,

Essmat,

Taay

2024

AIP Conference Proceedings

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Prevalence of Hyperthyroidism and Hypothyroidism and its Correlation with Serum Antithyroglobulin among patients in Kirkuk-Iraq ‎

Cited by 4 publications

References 16 publications

Investigating the Effect of Genetic Polymorphisms of Deiodinase Type 2 on Levothyroxine Dose Requirements in Patients with Hypothyroidism

Investigating the Effect of Genetic Polymorphisms of Deiodinase Type 2 on Levothyroxine Dose Requirements in Patients with Hypothyroidism

Bone and thyroid nexus in thyroid disease patients

The role of advanced glycation end products and oxidative stress in the pathophysiology of thyroid disorders

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