Prevalence of hypertriglyceridemia among Royal Thai Army personnel and its related cardiometabolic risk factors, from 2017 to 2021

Sakboonyarat, Boonsub; Poovieng, Jaturon; Jongcherdchootrakul, Kanlaya; Srisawat, Phutsapong; Hatthachote, Panadda; Mungthin, Mathirut; Rangsin, Ram

doi:10.1186/s12889-022-13992-2

Cited by 11 publications

(9 citation statements)

References 63 publications

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“…Study design and subjects. The RTAMED provides annual health examinations for RTA personnel through 37 RTA hospitals nationwide in Thailand, the Armed Forces Research Institute of Medical Sciences, and the Army Institute of Pathology 9,10 . Such data are reported to the RTAMED in Bangkok, Thailand.…”

Section: Methodsmentioning

confidence: 99%

Rising trends in the predicted 10-year risk of cardiovascular diseases among Royal Thai Army personnel from 2017 to 2021

Sakboonyarat

Poovieng

Jongcherdchootrakul

et al. 2023

Sci Rep

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Deaths from cardiovascular diseases (CVD) are becoming a growing threat to global health, including in Thailand. The aim of the present study was to identify the recent trends in the predicted 10-year risk of CVD among Royal Thai Army (RTA) personnel from 2017 to 2021. The predicted 10-year risk for CVD was calculated through the use of the 2008 updated version of the risk algorithm derived from the Framingham Heart Study data. The current study included 346,355 active-duty RTA personnel aged 30–60 years. The age- and sex-adjusted mean of the predicted 10-year risk for CVD significantly increased from 10.8% (95% CI: 10.8–10.9%) in 2017 to 11.7% (95% CI: 11.6–11.7%) in 2021 (p for trend < 0.001). The overall age- and sex-adjusted prevalence of intermediate-to-high predicted 10-year risk for CVD remarkably surged from 24.9% (95% CI: 24.4–25.4%) in 2017 to 29.5% (95% CI: 29.0–30.0%) in 2021 (p for trend < 0.001). The modifiable risk factors for CVD, including high systolic blood pressure, high body mass index, and current smoking in this population, should be alleviated to mitigate the risk for CVD in the future.

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Section: Methodsmentioning

confidence: 99%

Rising trends in the predicted 10-year risk of cardiovascular diseases among Royal Thai Army personnel from 2017 to 2021

Sakboonyarat

Poovieng

Jongcherdchootrakul

et al. 2023

Sci Rep

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“…High blood pressure was defined as an SBP of 140 mmHg or more or a DBP of 90 mmHg or more. High serum uric level was defined as 7 mg/dL or more [ 17 , 18 ]. Elevated aminotransferase was defined as AST or ALT equal to or greater than 40 U/L and 35 U/L among males and females, respectively [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study

et al. 2023

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Background Insulin resistance (IR) is a major pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity to assess IR and NAFLD due to its simplicity and low cost. The aim of the current study was to evaluate the relationship between the TyG index and aminotransferase. Methods A serial cross-sectional study was conducted among 232,235 Royal Thai Army (RTA) personnel aged 35–60 years from 2017–2021. Elevated aminotransferase was defined as ≥ 40 U/L and ≥ 35 U/L among males and females, respectively. A linear regression analysis between the TyG index and log-transformed aminotransferase was performed. High- and low-TyG index groups were divided according to Youden’s index cut point for predicting elevated aminotransferase. Multivariable logistic analysis was also utilized to investigate the association between the TyG index and elevated aminotransferase. Results The TyG index revealed a dose‒response relationship with log-transformed aminotransferase in both sexes and all age groups. The TyG index was positively associated with the prevalence of elevated aminotransferases. In comparison with the first TyG quartile (< 8.37), participants in the fourth quartile (> 9.23) had a higher chance for elevated ALT (AOR: 2.81, 95% CI: 2.71–2.90 for males and AOR: 4.01, 95% CI: 3.50–4.60 for females, P < 0.001 for both). In the fourth TyG quartile, the prevalence of elevated ALT was 47.8% and 40.2% in the participants aged 35–44 and male participants, respectively. Conclusion A high TyG index is a novel risk factor for elevated aminotransferase among RTA personnel. Those with a high TyG index should be screened for elevated aminotransferase, particularly males aged 35–44 years.

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“…The current study employed the dataset obtained from the annual health examination database of RTA personnel in 2017–2021 from the RTAMED in Bangkok, Thailand [ 15 , 16 ]. The RTAMED provides annual health examinations for active-duty RTA personnel through 37 RTA hospitals nationwide, the Army Institute of Pathology (AIP), and the Armed Forces Research Institute of Medical Sciences (AFRIMS).…”

Section: Methodsmentioning

confidence: 99%

“…The RTAMED provides health examinations for RTA personnel yearly through RTA hospitals nationwide, the AIP, and AFRIMS. A self-report using a standardized case report form was conducted during the health examination session in order to obtain characteristics data and behavioral factors, such as age, sex, smoking status, alcohol use, and exercise [ 15 , 16 ]. Furthermore, the annual health examination database of RTA personnel comprised body weight, height, systolic blood pressure (SBP), and diastolic blood pressure (DBP).…”

Section: Methodsmentioning

confidence: 99%

“…In Thailand, nearly 50,000 active-duty Royal Thai Army (RTA) personnel aged at least 35 years participate in yearly health examinations provided by the RTA Medical Department (RTAMED). Raised BP was still a crucial health issue among this population between 2017 and 2021 [ 15 ]. Therefore, we aimed to adopt an extensive database of RTA personnel's physical health examinations from 2017 to 2021 so that we can identify the association between elevated serum liver enzymes and raised BP.…”

Section: Introductionmentioning

confidence: 99%

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Association between raised blood pressure and elevated serum liver enzymes among active-duty Royal Thai Army personnel in Thailand

Sakboonyarat

Poovieng

Lertsakulbunlue

et al. 2023

BMC Cardiovasc Disord

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Background The relationship between hypertension (HT) and serum liver enzymes was reported in a few studies, but the findings were inconsistent. Therefore, the present study aimed to identify the association between elevated serum liver enzymes and raised BP through the use of a large sample of Royal Thai Army (RTA) personnel. Methods The dataset obtained from the annual health examination database of RTA personnel in Thailand was utilized. A total of 244,281 RTA personnel aged 35–60 were included in the current study. Elevated serum liver enzymes were defined as aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≥ 40 U/L in males and ≥ 35 U/L in females. HT was defined as systolic BP ≥ 140 or diastolic BP ≥ 90 mmHg. A multivariable linear regression model was used to estimate the coefficient and 95% confidence intervals (CI), whereas a multivariable logistic regression model was applied to estimate adjusted odds ratios (AORs) and 95% CI for the association between raised BP and serum liver enzymes. Results Compared to individuals with SBP < 120 and DBP < 80 mmHg, the β coefficients of log-transformed AST and ALT were 0.13 (95% CI: 0.12–0.13) and 0.11 (95% CI: 0.11–0.12) in males with HT. Meanwhile, the β coefficients of log-transformed AST and ALT were 0.03 (95% CI: 0.02–0.04) and 0.07 (95% CI: 0.05–0.08) in females with HT. In males, HT was associated with elevated AST (AOR: 1.92; 95% CI: 1.85–2.01) and elevated ALT (AOR: 1.43; 95% CI: 1.38–1.48). On the other hand, in females, HT was associated with elevated AST (AOR: 1.42; 95% CI: 1.21–1.66) and elevated ALT (AOR: 1.38; 95% CI: 1.21–1.57). Conclusion Raised BP was positively correlated with elevated AST and ALT in active-duty RTA personnel. Moreover, HT was independently attributed to higher odds of elevated AST and ALT in comparison to optimal BP in both males and females. Furthermore, the relationship between serum liver enzymes and BP was modified by sex.

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Prevalence of hypertriglyceridemia among Royal Thai Army personnel and its related cardiometabolic risk factors, from 2017 to 2021

Cited by 11 publications

References 63 publications

Rising trends in the predicted 10-year risk of cardiovascular diseases among Royal Thai Army personnel from 2017 to 2021

Rising trends in the predicted 10-year risk of cardiovascular diseases among Royal Thai Army personnel from 2017 to 2021

Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study

Association between raised blood pressure and elevated serum liver enzymes among active-duty Royal Thai Army personnel in Thailand

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