Prevalence of hypertriglyceridemic waist and association with risk of type 2 diabetes mellitus: a meta‐analysis

Tian, Xiaoping; Luo, Xinping; Wang, Chongjian; Li, Yin; Pang, Chao; Feng, Ting; Wang, Bingyuan; Lu, Zhen; Li, Linlin; Yang, Xiangyu; Zhang, Hongyan; Zhao, Jiupeng; Hu, Dongsheng

doi:10.1002/dmrr.2725

Cited by 27 publications

(21 citation statements)

References 42 publications

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“…The presence of an elevated waist circumference simultaneously with an elevated triglyceride concentration could indicate inability to store surplus energy in SAT because of dysfunctional adipose tissue . Thereby, the hypertriglyceridemic waist phenotype is a simple clinical marker of the presence of dysfunctional fat, such as VAT, and thus of metabolic disorders . In agreement with previous observations, the present study shows that the hypertriglyceridemic waist is positively associated with visceral adiposity and with cardiac and hepatic fat.…”

Section: Discussionsupporting

confidence: 91%

Hypertriglyceridemic Waist: A Simple Marker of High‐Risk Atherosclerosis Features Associated With Excess Visceral Adiposity/Ectopic Fat

LeBlanc

François

Bertrand

et al. 2018

JAHA

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BackgroundSubclinical atherosclerosis identification remains challenging; abdominal visceral adiposity may improve risk stratification beyond traditional cardiovascular risk factors. Hypertriglyceridemic waist, a visceral adiposity marker combining elevated triglycerides (≥2 mmol/L) and waist circumference (≥90 cm), has been related to carotid atherosclerosis, although associations with high‐risk features, including lipid‐rich necrotic core (LRNC), remain unknown. We tested the hypothesis that hypertriglyceridemic waist is an independent marker of high‐risk atherosclerosis features.Methods and ResultsIn this cross‐sectional study including 467 white men (mean age, 45.9±14.8 years; range 19.4–77.6 years), carotid atherosclerosis characteristics were examined by magnetic resonance imaging and associations with hypertriglyceridemic waist and benefits beyond Framingham Risk Score (FRS) and Pathobiological Determinants of Atherosclerosis in Youth (PDAY) were determined. Subclinical carotid atherosclerosis was present in 61.9% of participants, whereas 50.1% had LRNC. Hypertriglyceridemic waist was associated with carotid maximum wall thickness (P=0.014), wall volume (P=0.025), normalized wall index (P=0.004), and Carotid Atherosclerosis Score (derived from wall thickness and LRNC; P=0.049). Hypertriglyceridemic waist was associated with carotid LRNC volume beyond FRS (P=0.037) or PDAY (P=0.015), contrary to waist circumference alone (both P>0.05). Although 69.7% and 62.0% of participants with carotid atherosclerosis and/or LRNC were not high‐risk by FRS or PDAY, respectively, hypertriglyceridemic waist correctly reclassified 9.7% and 4.5% of them, respectively. Combining hypertriglyceridemic waist with FRS (net reclassification improvement=0.17; P<0.001) or PDAY (net reclassification improvement=0.05; P=0.003) was superior to each score alone in identifying individuals with carotid atherosclerosis and/or LRNC.ConclusionsHypertriglyceridemic waist is an independent marker of carotid high‐risk atherosclerosis features in men, improving on FRS and PDAY risk score.

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Section: Discussionsupporting

confidence: 91%

Hypertriglyceridemic Waist: A Simple Marker of High‐Risk Atherosclerosis Features Associated With Excess Visceral Adiposity/Ectopic Fat

LeBlanc

François

Bertrand

et al. 2018

JAHA

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“…The literature review was evident that hypertriglyceridemia is linked to high glucose levels and increased risk of type 2 diabetes [12-13]. In our study, correlation of HbA1c with high triglycerides signifies HbA1c as a direct marker of hypertriglyceridemia and an indirect marker of risk assessment of coronary artery disease.…”

Section: Introductionsupporting

confidence: 56%

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Naqvi

Naveed

Ali

et al. 2017

Cureus

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ContextDyslipidemia is quite prevalent in non-insulin dependent diabetes mellitus. Maintaining tight glycemic along with lipid control plays an essential role in preventing micro- and macro-vascular complications associated with diabetes. PurposeThe main purpose of the study was to highlight the relationship between glycosylated hemoglobin (HbA1c) and triglyceride levels. This may in turn help in predicting the triglyceride status of type 2 diabetics and therefore identifying patients at increased risk from cardiovascular events. Hypertriglyceridemia is one of the common risk factors for coronary artery disease in type 2 diabetes mellitus (DM). Careful monitoring of the blood glucose level can be used to predict lipid status and can prevent most of the complications associated with the disease.MethodThis is a cross-sectional study using data collected from the outpatient diabetic clinic of Jinnah Postgraduate Medical Centre (JPMC) Karachi, Pakistan. Patients of age 18 years and above were recruited from the clinic. A total of consenting 509 patients of type 2 diabetes mellitus were enrolled over a period of 11 months. For statistical analysis, SPSS Statistics for Windows, Version 17.0 ( IBM Corp, Armonk, New York) was used and Chi-square and Pearson’s correlation coefficient was used to find the association between triglyceride and HbA1c. The HbA1c was dichotomized into four groups on the basis of cut-off. Chi-square was used for association between HbA1c with various cut-off values and high triglyceride levels. Odds-ratio and its 95% confidence interval were calculated to estimate the level of risk between high triglyceride levels and HbA1c groups. The p-value < 0.05 was considered statistically significant for all the tests applied for significance.ResultThe association of high triglyceride was evaluated in four different groups of HbA1c, with a cut-off seven, eight, nine and 10 respectively. With HbA1c cut-off value of 7%, 74% patients had high triglycerides and showed a significant association with high triglyceride levels at p < 0.001 and odds ratio was 2.038 (95% confidence interval: 1.397 – 2.972). Logistic regression models were adjusted for demographic factors (age, race, gender), lifestyle factors (smoking, body mass index, lifestyle) and health status factors (blood pressure, physician-rated health status).ConclusionAfter adjusting for relevant covariates, glycated hemoglobin was positively correlated with high triglyceride. Hence, HbA1c can be an indicator of triglyceride level and can be one of the predictors of cardiovascular risk factors in type 2 diabetes mellitus.

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“…4 Therefore, implementing effective T2DM prevention strategies and early detection programs is essential to reduce the disease burden. 5,6 Obstructive sleep apnea (OSA) is a treatable chronic sleep disorder characterized by episodes of sleep apnea and hypopnea during sleep causing recurrent episodes of hypoxemia and hypercapnia. [7][8][9] A recent populationbased study in Switzerland reported a high prevalence of moderate to severe OSA of 23% and 49% for women and men, respectively, and confirmed the strong association between OSA and relevant comorbidities such as T2DM, hypertension, metabolic syndrome, and cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Obstructive sleep apnea and risk of type 2 diabetes mellitus: A systematic review and dose‐response meta‐analysis of cohort studies

Qie

Zhang

Liu

et al. 2020

Journal of Diabetes

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Background: This meta-analysis was performed to quantitatively evaluate the dose-response association between obstructive sleep apnea (OSA) and risk of type 2 diabetes mellitus (T2DM).Methods: PubMed, Embase, and Web of Science were searched up to 12 December 2018 for articles that assessed the OSA-T2DM association. Random effects models were used to analyze the quantitative association between OSA and risk of T2DM. Restricted cubic splines were used to model the doseresponse association between apnea-hypopnea index (AHI), used to assess the severity of OSA according to events/h, and risk of T2DM. Results:We included 16 cohort studies in our meta-analysis. During a median follow-up of 10.5 years (range: 3.0-22.0), 19 355 T2DM cases were reported among 338 912 study participants. The pooled relative risk of T2DM was 1.40 (95% CI, 1.32-1.48) for OSA in the binary meta-analysis and 1.08 (1.01-1.14) for each 5-event/h increase in AHI value. We found a positive linear association between OSA and T2DM risk.Conclusions: Our dose-response meta-analysis revealed a linear association between OSA and T2DM. Highlights• Obstructive sleep apnea (OSA) is a treatable chronic sleep disorder characterized by episodes of sleep apneas and hypopneas during sleep, increased oxidative stress, inflammation, and sleep fragmentation and is associated with significant comorbidities. • Our systematic review and meta-analysis shows that people with OSA are at higher risk of type 2 diabetes mellitus (T2DM), which suggests that we should detect and treat OSA early to prevent T2DM.

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Prevalence of hypertriglyceridemic waist and association with risk of type 2 diabetes mellitus: a meta‐analysis

Abstract: Introduction A meta-analysis of studies assessing the prevalence of hypertriglyceridemic waist and an association with risk of type 2 diabetes mellitus (T2DM).

Cited by 27 publications

References 42 publications

Hypertriglyceridemic Waist: A Simple Marker of High‐Risk Atherosclerosis Features Associated With Excess Visceral Adiposity/Ectopic Fat

Hypertriglyceridemic Waist: A Simple Marker of High‐Risk Atherosclerosis Features Associated With Excess Visceral Adiposity/Ectopic Fat

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Obstructive sleep apnea and risk of type 2 diabetes mellitus: A systematic review and dose‐response meta‐analysis of cohort studies

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