Prevalence of hypothyroidism in patients with frozen shoulder

Schiefer, Márcio; Teixeira, Patrícia de Fátima dos Santos; Fontenelle, César Rubens da Costa; Carminatti, Tiago; Santos, Danielle Anjos dos; Righi, Lucas D.; Conceição, Flávia Lúcia

doi:10.1016/j.jse.2016.04.026

Cited by 53 publications

(57 citation statements)

References 32 publications

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“…28,29 An association between thyroid disease and frozen shoulder remains undetermined, but in our study, we found 31 patients (25.8%) to be suffering from hypothyroidism, which is similar to the study by Schiefer et al which found 27.2% of the 93 frozen shoulder patients to be suffering from hypothyroidism. 30 The disabilities of the arm, shoulder and hand (DASH) score significantly decreased in both the groups in this study at each follow up which is similar to the study by Buchbinder in 2004 which showed decrease in DASH score at each follow up for 3 months after short course prednisolone therapy. 9 In glenohumeral group it decreased from 66.95±9.9 to 27.45±9.31 at 3 months and in the subacromial group it decreased from 67.52±10.65 to 26.81±11.14 at 3 months.…”

Section: Discussionsupporting

confidence: 89%

Comparison of functional outcome of ultrasound guided glenohumeral and subacromial methylprednisolone acetate injections in frozen shoulder

Chopra

Vasdev

2018

Int J Res Orthop

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Background: Frozen shoulder also known as adhesive capsulitis is a common cause for limitation of motion and pain of the shoulder joint with an incidence of 2-5% in the general population. The aim of the study was to assess the functional outcome of ultrasound guided glenohumeral and subacromial methylprednisolone acetate steroid injection in patients with frozen shoulder.Methods: 120 patients with frozen shoulder were randomly divided into 2 groups according to site i.e. glenohumeral and subacromial. Ultrasound-guided methylprednisolone acetate (80 mg) injection was administered. At follow up pain was being measured using VAS scale and functional outcome was measured using the DASH score and Constant score at day 0, 1 followed by 1, 3, 6 weeks and at 3 months.Results: The VAS score of glenohumeral decreased from 6.5±0.95 to 2.25±0.86 at 3 months and in subacromial it decreased from 6.37±1.07 to 2.3±0.72. DASH score in glenohumeral group decreased from 66.95±9.9 to 27.45±9.31 at 3 months and in the subacromial group it decreased from 67.52±10.65 to 26.81±11.14 at 3 months. In glenohumeral group Constant score increased from 46.63±7.18 to 72.66±7.38 at 3 months and in the subacromial group it increased from 47.92±6.91 to 70.28±6.97 at 3 months.Conclusions: Spontaneous recovery does not necessarily occur even after a long period, so we recommend that these modalities should be offered to all patients with frozen shoulder and it would be of more value if carried out at an early stage of the disorder.

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Section: Discussionsupporting

confidence: 89%

Comparison of functional outcome of ultrasound guided glenohumeral and subacromial methylprednisolone acetate injections in frozen shoulder

Chopra

Vasdev

2018

Int J Res Orthop

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“…However, their study specifically aimed at hyperthyroidism patients and did not include other thyroid diseases such as hypothyroidism, thyroid cancer or nodules. Another study in 2016 revealed that the prevalence of hypothyroidism was significantly higher in patients with AC, but this case‐control study only emphasized hypothyroidism . Our study was an 11‐year follow‐up study and it included all thyroid diseases (ICD‐9 codes 240‐246, including simple and unspecified goiter, nontoxic nodular goiter, thyrotoxicosis with or without goiter, congenital hypothyroidism, acquired hypothyroidism, thyroiditis and other disorders of the thyroid).…”

Section: Discussionmentioning

confidence: 99%

Increased risk of adhesive capsulitis among patients with gout: A nationwide population‐based matched‐cohort study

Hsu

Sun

et al. 2018

Int J of Rheum Dis

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Aim:The pathophysiology of adhesive capsulitis (AC) is uncertain. We noted patients with gout seemed to have higher incidence rates of AC than other people in our clinic. We did not know the true relationship between gout and AC because there are no published reports so far. The aim of this study is to verify the risk of developing AC following gout exposure. Method:The authors used the National Health Insurance Research Database of Taiwan to select 39 094 subjects with newly diagnosed gout and randomly extracted 78 188 matched control subjects. All of the subjects in study and control groups were followed until the event of AC. Cox proportional hazard regression analyses were performed to evaluate the subsequent risk of AC.Results: There was significance since the 8th year of tracking that patients with gout had a higher risk for AC (log-rank test P < .001). Cox regression showed the adjusted hazard ratio of developing AC for patients with gout was 1.71 (95% CI = 1.451-2.565, P < .001) than the control group. Stratified analysis showed that gout patients have a higher risk for AC regardless of diabetes mellitus, stroke or carotid artery disease (P < .05). Conclusions:This study showed that gout is an independent risk factor for developing AC.

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“…Dyslipidemia and high blood pressure seem to increase the risk of this shoulder injury. Hypothyroidism is also a FS risk factor, especially in females . Possible racial differences have been described …”

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confidence: 99%

“…Hypothyroidism is also a FS risk factor, especially in females. 9,10 Possible racial differences have been described. 4 The etiology of FS remains unclear.…”

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confidence: 99%

Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: A case‐control study

Cohen¹,

Leal

Loyola

et al. 2019

Journal Orthopaedic Research

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Frozen shoulder is a condition of loss of active and passive motion as result of inflammatory contracture and fibrosis of the joint capsule. We hypothesize that genetic variants in genes involved in these processes such as genes that play a role in extracellular matrix homeostasis (collagens, glycoproteins, genes involved in TGFβ signaling, and metalloproteinases and its inhibitors) may contribute to the susceptibility to frozen shoulder. We evaluated eighteen SNPs of genes involved in extracellular matrix homeostasis in 186 cases (Nfemales = 114; Nmales = 72) of frozen shoulder and 600 age‐matched controls (Nfemales = 308; Nmales = 292). Multivariate logistic regressions were carried out with age, gender, genetic ancestry, and common comorbidities as covariates. Carriers of the C allele of MMP13 rs2252070 and G/G MMP9 (rs17576 A>G/rs17577 G>A) haplotype may have an increased risk of frozen shoulder (p = 0.002, OR = 1.64, 95%CI = 1.20–2.26, and p = 0.046, OR = 1.40, 95%CI = 1.01–1.95, respectively), especially in females (p = 0.005, OR = 1.91, 95%CI = 1.22–2.99, and p = 0.046, OR = 1.59, 95%CI = 1.01–2.51, respectively). In females, the G allele of MMP9 rs17576 tended to contribute to the susceptibility to the studied disease (p = 0.05, OR = 1.51, 95%CI = 0.97–2.33). In contrast, the presence of the C allele of TGFB1 rs1800470 seems to be associated with a reduced risk (p = 0.04, OR = 0.47, 95%CI = 0.23–0.96) while the GG‐genotype of TGFBR1 rs1590 was associated with increased risk (p = 0.027, OR = 4.11, 95%CI = 1.17–14.38) to frozen shoulder development in males. Thus, we identified genetic variants that were independent risk factors that can aid in the risk assessment of frozen shoulder reinforcing the involvement of MMP and TGFβ signaling in disease development. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res

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Prevalence of hypothyroidism in patients with frozen shoulder

Cited by 53 publications

References 32 publications

Comparison of functional outcome of ultrasound guided glenohumeral and subacromial methylprednisolone acetate injections in frozen shoulder

Comparison of functional outcome of ultrasound guided glenohumeral and subacromial methylprednisolone acetate injections in frozen shoulder

Increased risk of adhesive capsulitis among patients with gout: A nationwide population‐based matched‐cohort study

Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: A case‐control study

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