Prevalence of Helicobacter Pylori in gastric cancer in a South‐east Asian Population by ¹⁴C‐Urea breath test

Abstract

Active H. pylori infection is highly prevalent in gastric cancer in a South-East Asian population. The 14C-urea breath test is a highly sensitive method for detecting the presence of H. pylori even in gastric adenocarcinoma irrespective of the stage.

Prognostic Role of Intragastric Cytopathology and Microbiota in Surgical Patients with Stomach Cancer

“…[ 18 19 20 21 22 23 24 25 ] Concerning the gastric microbial community, H. pylori infection indeed plays a pivotal role in GC carcinogenesis. [ 18 19 20 21 22 23 24 25 32 33 ] However, latest studies suggested that colonization of other non- H. pylori bacteria in the stomach (such as Propionibacterium acnes, Prevotella copri, and Eubacterium cylindroides) can also stimulate GC risk by producing proinflammatory cytokines such as IL 15 and lymphocytic gastritis. [ 34 35 36 37 ] Taking a cue from such new literature data, for this study, we wanted to enrich our previously reported line of research (the cytopathologic analysis of GL from GC patients) by combining it with examination of intragastric MB: as a consequence, we assessed the cyto-microbiologic parameter of “GL MB.” In our patient population, analysis of this character provided original and interesting results.…”

“…Our findings, in fact, strengthening the carcinogenic role executed by Metastasis VI and H. pylori but also suggesting the cooperation between such features and the other non- H. pylori pro-oncogenic germs within the endogastric microenvironment, showed that GL1 MB1 GC patients had a poorer OS in comparison with GL1 MB0 GC subjects. [ 18 19 20 21 22 23 24 25 32 33 34 35 36 ] In this regard, the treatment of non- H. pylori bacteria could exert a conspicuous benefit for individuals with related precancerous gastric lesions (such as lymphocytic gastritis), just as already proven by antibiotic therapy for H. pylori infection. [ 30 37 ] Further studies dealing with GC patients showing malignant endogastric exfoliation in combination with intragastric microbiota (GL1 MB1 GC subjects) are needed to corroborate our data.…”

Diagnostic approach to Helicobacter pylori-related gastric oncogenesis

“…Some studies indicate that the UBT value is not a sensitive predictor of gastric cancer and low values are related with risk of gastric malignancy; compared with gastritis and peptic ulcer, UBT values are significantly lower in patients with gastric cancer [ 92 , 93 ]. Nevertheless, other studies indicate that the 14 C-UBT is highly sensitive for detecting the occurrence of H. pylori even in gastric cancer, regardless of its stage; H. pylori is present in 98% of patients with gastric cancer (positive by UBT), and active H. pylori infection occurs in early and advanced gastric cancer as estimated by UBT [ 94 ]. Therefore, since H. pylori eradication significantly decreases the incidence of gastric cancer without concomitant adverse events [ 95 ], UBT may offer clinicians the ability to detect this high-risk group of patients indirectly by this readily available and noninvasive test.…”