Prevalence of Mycoplasma genitalium infection and macrolide resistance in pregnant women receiving prenatal care

Retrospective Evaluation of Mycoplasma genitalium Prevalence and Macrolide Resistance in a Study Cohort of Pregnant Women in Birmingham, AL, From 1997 to 2001

“…16,25 Comparatively, vast differences were present in prevalence of MRMs between our retrospective study cohort (1997-2001) compared with the recent prospective study cohort. 22 No MRMs were detected among MG strains in this study's cohort, whereas MRM prevalence was 41% in our more recent Birmingham cohort. 22 A similar cohort of pregnant women seen for routine prenatal care in Houston, TX, in 2018 to 2019 had an MRM prevalence of 31%.…”

“…22 No MRMs were detected among MG strains in this study's cohort, whereas MRM prevalence was 41% in our more recent Birmingham cohort. 22 A similar cohort of pregnant women seen for routine prenatal care in Houston, TX, in 2018 to 2019 had an MRM prevalence of 31%. 16 The prevalence of MRM in recent studies in nonpregnant women in the United States shows even higher MRM rates of ≥50%.…”

“…This study period was approximately 20 years earlier than our recent prospective study period, in which we examined the prevalence of MG infection and MRMs in a similar cohort of pregnant women in Birmingham and seen by providers served by the same academic program. 22 The MG infection prevalence was similar between the earlier and recent Birmingham cohorts (11% vs. 8%), and but was slightly lower than or equal to prevalence rates in similar studies in pregnant women in the United States. 16,25 Comparatively, vast differences were present in prevalence of MRMs between our retrospective study cohort (1997-2001) compared with the recent prospective study cohort.…”

“…In this retrospective study, we examined the prevalence of MG infection and MRMs in a study cohort of pregnant women in Birmingham, AL, and select adjacent areas from 1997 to 2001. This study period was approximately 20 years earlier than our recent prospective study period, in which we examined the prevalence of MG infection and MRMs in a similar cohort of pregnant women in Birmingham and seen by providers served by the same academic program 22 . The MG infection prevalence was similar between the earlier and recent Birmingham cohorts (11% vs. 8%), and but was slightly lower than or equal to prevalence rates in similar studies in pregnant women in the United States 16,25 .…”

“…Despite this hypothesis, more remote data on MRM frequency in the United States (before 2014) are lacking to support this assumption 11 . We recently published findings from a prospective study that found an MG infection prevalence of 8% and MRM frequency of 41% in pregnant women seen for routine prenatal care in Birmingham, AL, from 2020 to 2021 22 . In this study, we sought to retrospectively evaluate the prevalence of MG and MRMs within a cohort of pregnant women enrolled approximately 20 years earlier, from a similar population in Birmingham to compare differences in frequency of MRMs between these periods.…”