Prevalence of RUNX1 gene alterations in de novo adult acute myeloid leukemia
Hoda M Abd El-Ghany,
Mona S El Ashry,
Mona S Abdellateif
et al.
Abstract:BACKGROUND
Acute myeloid leukemia (AML) is a complicated disease with uncontrolled hematopoietic precursor proliferation induced by various genetic alterations. Runt-related transcription factor-1 (RUNX1 ) is commonly disrupted by chromosomal translocations in hematological malignancies.
AIM
To characterize RUNX1 gene rearrangements and copy number variations in newly diagnosed adult AML patients, with an emphasis on the impact of clinical and laboratory features on the outcome.
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