Prevalence of <i><scp>H</scp>elicobacter pylori</i> Infection by Birth Year and Geographic Area in Japan

Ueda, Junko; Gosho, Masahiko; Inui, Yoshikatsu; Matsuda, T; Sakakibara, Makoto; Mabe, Katsuhiro; Nakajima, Shigenori; Shimoyama, Tadashi; Yasuda, Mitsugi; Kawai, Takashi; Murakami, Kazunari; Kamada, Takenobu; Mizuno, Motowo; Kikuchi, Shogo; Lin, Yingsong; Kato, Mototsugu

doi:10.1111/hel.12110

Cited by 92 publications

(106 citation statements)

References 22 publications

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“…In this study, the H. pylori prevalence in China was found to be significantly lower than that reported in previous studies (13)(14)(15)(16). This prevalence was consistent with those reported in some Western developed countries, and even it was surprisingly lower than those reported in some developed countries (17)(18)(19)(20) In recent years, the H. pylori prevalence has been decreasing in many areas of the world (22,23). The birth cohort effect may partially account for this phenomenon (24).…”

Section: Discussionsupporting

confidence: 89%

Decreasing prevalence of Helicobacter pylori according to birth cohorts in urban China

Yang²,

Yang³

et al. 2017

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 89%

Decreasing prevalence of Helicobacter pylori according to birth cohorts in urban China

Yang²,

Yang³

et al. 2017

Turk J Gastroenterol

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“…The prevalence rate of H. pylori infection in this study was similar to that of Japanese patients ≥50 years of age [14], and the statistical compatibility (model square test < 0.01, Hosmer-Lemeshow goodness of fit test: P = 0.900, Nagelkerke R 2 : 0.454, and discriminant hitting ratio: 86.0%) was considered good. H. pylori infection is a worldwide infectious disease and osteoporosis threatens life prognosis by lumbar or hip fractures.…”

Section: Discussionsupporting

confidence: 54%

The Relationship betweenH. pyloriInfection and Osteoporosis in Japan

Asaoka

Nagahara

Hojo

et al. 2014

Gastroenterology Research and Practice

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Background and Objective. H. pylori infection causes a chronic inflammation in the gastric mucosa. However, this local inflammation may result in extra-digestive conditions. Our aim is to investigate the relationship between H. pylori infection and osteoporosis in Japan. Methods. This cross-sectional study was conducted among outpatients at the Juntendo University Hospital between 2008 and 2014. Participants for patient profile, H. pylori infection status, comorbidity, internal medical therapies, lumbar dual-energy X-ray absorptiometry (DXA), and bone turnover marker were collected and upper gastrointestinal endoscopy for reflux esophagitis, hiatal hernia, peptic ulcer disease (PUD), and endoscopic gastric mucosal atrophy (EGA) was performed. The diagnosis of osteoporosis was performed in accordance with the Japanese criteria. We investigated risk factors of osteoporosis. Results. Of the eligible 200 study subjects, 41 cases were of osteoporosis. Bivariate analysis showed that age, being female, BMI, alcohol, smoking, H. pylori, bone-specific ALP, PUD, and EGA were related to osteoporosis. Multivariate analysis showed that age (OR 1.13; 95%CI 1.07–1.20), being female (OR 4.77; 95%CI 1.78–12.77), BMI (OR 0.79; 95%CI 0.68–0.92), H. pylori (OR 5.33; 95%CI 1.73–16.42), and PUD (OR 4.98; 95%CI 1.51–16.45) were related to osteoporosis. Conclusions. H. pylori infection may be a risk factor of osteoporosis in Japan.

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“…The prevalence of H. pylori infection in adults also shows geographic variation in Japan [14]. There is no report on such prevalence in Akita Prefecture, but in a study comparing seven Japanese regions (Hokkaido, Aomori, Yamagata, Gunma, Aichi, Shiga and Kagawa), Yamagata Prefecture, located just next to Akita Prefecture, showed the highest prevalence (54.5%).…”

Section: Discussionmentioning

confidence: 99%

The administrative project of Helicobacter pylori infection screening among junior high school students in an area of Japan with a high incidence of gastric cancer

et al. 2017

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Objective Helicobacter pylori infection is a common chronic infection that is closely associated with gastric cancer, known to be decreasing worldwide. We set up an administrative project of screening examination for H. pylori infection in junior high school students in Akita Prefecture to investigate the current prevalence of H. pylori infection in childhood in an area where the incidence of gastric cancer is particularly high. Subjects and methods All students in their second or third year of junior high school (13 to 15 years old) in two cities in Akita Prefecture were recruited. First, a urine-based enzyme-linked immunosorbent assay for detection of H. pylori antibody was performed. Then, a 13 C-urea breath test ( 13 C-UBT) was carried out in students who tested positive on the urinary test. Written informed consent was obtained from all participants and their parents. Results A total of 1813 students were recruited in this study; 1765 (97.3%) students agreed to participate in this project and underwent a screening examination. Among 96 students (5.4%) testing positive for H. pylori on the initial screening examination, 90 (93.7%, 90/96) underwent a subsequent 13 C-UBT, and 85 (4.8%, 85/1765) were diagnosed as positive for H. pylori. Conclusions The current prevalence of H. pylori infection among students was low even in an area of Japan with a high incidence of gastric cancer.

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Prevalence of Helicobacter pylori Infection by Birth Year and Geographic Area in Japan

Abstract: The prevalence of H. pylori infection increases with age and exhibits geographic variation in Japan. There has been a striking decrease in the prevalence of H. pylori infection, especially in younger Japanese populations.

Cited by 92 publications

References 22 publications

Decreasing prevalence of Helicobacter pylori according to birth cohorts in urban China

Decreasing prevalence of Helicobacter pylori according to birth cohorts in urban China

The Relationship betweenH. pyloriInfection and Osteoporosis in Japan

The administrative project of Helicobacter pylori infection screening among junior high school students in an area of Japan with a high incidence of gastric cancer

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